Characterization of Chemical Exposome in A Paired Human Preconception Pilot Study DOI
Jaye Marchiandi, Sonia Dagnino, Deirdre Zander‐Fox

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(46), P. 20352 - 20365

Published: Nov. 7, 2024

Parental preconception exposure to synthetic chemicals may have critical influences on fertility and reproduction. Here, we present a robust LC-MS/MS method covering up 95 diverse xenobiotics in human urine, serum, seminal follicular fluids support exposome-wide assessment reproductive health outcomes. Extraction recoveries of validated analytes ranged from 62% 137% limits quantification 0.01 6.0 ng/mL all biofluids. We applied the cohort Australian couples (

Language: Английский

Association between exposure to perfluoroalkyl substances (PFAS) and endometriosis in the ENDEA case-control study DOI Creative Commons
Teresa de Haro-Romero,

Francisco M. Peinado,

Fernando Vela-Soria

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175593 - 175593

Published: Aug. 23, 2024

Perfluoroalkyl substances (PFAS) are environmental contaminants present in a wide range of consumer products and frequently detected drinking water. They have been linked to adverse reproductive health outcomes women, but there is limited human evidence on the association PFAS exposure with endometriosis. To explore between plasma concentrations several PFAS, considered individually as mixture, risk endometriosis women childbearing age. Between 2018 2020, 42 patients 90 controls undergoing abdominal surgery were recruited at two public hospitals Granada, Spain. The presence or absence was ascertained by laparoscopic inspection pelvis biopsy suspected lesions (histological diagnosis). Concentrations 10 quantified samples from participants. Unconditional logistic regression employed examine associations individual summed short (∑SC) long-chain (∑LC) odds endometriosis, quantile g-computation used assess their mixture effect. In models adjusted for age, schooling, parity, perfluorotridecanoic acid (PFTrDA) associated higher (odds ratio [OR] = 1.74; 95 % CI 1.11–2.73 per 2-fold increase concentrations), while marginally significant found perfluorohexane sulfonate (PFHxS) (OR 1.45, 0.94–2.21) ∑SC 1.48; 0.96–2.30). No remaining PFAS. non-significantly 1.7-fold (95 0.73–3.80), perfluorononanoic (PFNA), PFHxS, PFTrDA being major contributors this These findings suggest that certain may However, given modest sample size, further studies warranted verify these results.

Language: Английский

Citations

5
Methods for sample pretreatment and detection of per- and polyfluoroalkyl substances in biological samples: A review DOI
Yuanxing Liu, Wenmei Zhang,

Guizhen Zhu

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118206 - 118206

Published: Feb. 1, 2025

Language: Английский

Citations

0
Research Progress in Current and Emerging Issues of PFASs’ Global Impact: Long-Term Health Effects and Governance of Food Systems DOI Creative Commons
Jocelyn C. Lee, Slim Smaoui,

John Duffill

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 958 - 958

Published: March 11, 2025

Per- and polyfluoroalkyl substances (PFASs) are found everywhere, including food, cosmetics, pharmaceuticals. This review introduces PFASs comprehensively, discussing their nature identifying interconnection with microplastics impacts on public health the environment. The human cost of decades delay, cover-ups, mismanagement plastic waste is outlined briefly explained. Following that, long-term effects critically assessed. Risk assessment then reviewed, mentioning different tools models. Scientific research in United States America analyzed, taking into consideration Center for Disease Control (CDC)'s PFAS Medical Studies Guidelines. impact activities studies around world have focused levels food products dietary intake countries such as China, European countries, USA Australia. Moreover, drinking water regard to risks, mitigation, regulatory needs, account chemical contaminants safety. Finally, briefings specific regions discussed, referring Australia, Vietnam, Canada, Europe, (USA), South America, Africa. crisis a multifaceted issue, exacerbated by mismanagement, it discussed context applying following problem-solving analytical tools: Domino Effect Model accident causation, Swiss Cheese Theory Model, Ishikawa Fish Bone Root Cause Analysis. Last but not least, PFASs' Sustainable Development Goals (SDGs) 2030 rigorously discussed.

Language: Английский

Citations

0
Characterization of Chemical Exposome in A Paired Human Preconception Pilot Study DOI
Jaye Marchiandi, Sonia Dagnino, Deirdre Zander‐Fox

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(46), P. 20352 - 20365

Published: Nov. 7, 2024

Parental preconception exposure to synthetic chemicals may have critical influences on fertility and reproduction. Here, we present a robust LC-MS/MS method covering up 95 diverse xenobiotics in human urine, serum, seminal follicular fluids support exposome-wide assessment reproductive health outcomes. Extraction recoveries of validated analytes ranged from 62% 137% limits quantification 0.01 6.0 ng/mL all biofluids. We applied the cohort Australian couples (

Language: Английский

Citations

0