Cited by Effects of atrazine, diuron and glyphosate mixtures on zebrafish embryos: acute toxicity and oxidative stress responses

Investigate the binding of pesticides with the TLR4 receptor protein found in mammals and zebrafish using molecular docking and molecular dynamics simulations DOI

Sandeep Yadav, M. Aslam,

Ayushi Prajapat

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 18, 2024

The widespread use of pesticides poses significant threats to both environmental and human health, primarily due their potential toxic effects. study investigated the cardiovascular toxicity selected pesticides, focusing on interactions with Toll-like receptor 4 (TLR4), an important part innate immune system. Using computational tools such as molecular docking, dynamics (MD) simulations, principal component analysis (PCA), density functional theory (DFT) calculations, ADME analysis, this identified C160 having lowest binding affinity (-8.2 kcal/mol), followed by C107 C165 (-8.0 kcal/mol). RMSD, RMSF, Rg, hydrogen bond metrics indicated formation stable complexes between specific TLR4. PCA revealed structural changes upon ligand binding, affecting stability flexibility, while DFT calculations provided information about stability, reactivity, polarity compounds. studies highlighted solubility, permeability, metabolic C107, C160, C165, suggesting for bioavailability impact toxicity. exhibit higher bioactivity scores, indicating favourable absorption, metabolism, distribution properties. also violated rule where weight is greater than 500 g/mol. Further, NCI post MD conformations confirmed ligands at pocket. shed light mechanisms pesticide-induced toxicity, aiding in development strategies mitigate harmful effects health.

Language: Английский

Citations

Integrated Toxicity Assessment of Complex Chemical Mixtures in Catalytic Reactions DOI

Andrey Kolesnikov, Ksenia S. Egorova, Valentine P. Ananikov

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137784 - 137784

Published: Feb. 27, 2025

Language: Английский

Citations

Pyriproxyfen toxicity to fish and crustaceans: a literature review DOI

Flávio Kiyoshi Tominaga, Rafaella da Silva Brito, Juliana Nascimento

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 274, P. 121295 - 121295

Published: March 4, 2025

Language: Английский

Citations

Chronic exposure to low concentration of Diflubenzuron and Pyriproxyfen induces brain oxidative stress and inflammation and alters locomotion in zebrafish (Danio rerio) DOI

Júlia Robert de Sousa Teixeira,

Augusto Monteiro de Souza,

João Vitor de Macedo-Sampaio

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 264, P. 120278 - 120278

Published: Nov. 1, 2024

Language: Английский

Citations

Pyriproxyfen, villain or good guy? A brief review DOI

Andressa Pereira Cabral, Fabrício Pereira Dos Santos Maia, D’Angelo Carlo Magliano

et al.

Archives of Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 68(special issue)

Published: Jan. 1, 2024

Pyriproxyfen (PPF) acts as a juvenile growth regulator, interfering with normal metamorphosis and blocking the development of insects into adulthood. Although World Health Organization (WHO) considers use PPF at concentration 0.01 mg/L unlikely to pose health risks, recent studies have unveiled potential risks associated exposure non-target organisms. Exposure disrupts insect primarily by mimicking hormones; therefore, concerns linger over its impact on unintended species. Studies highlighted adverse effects aquatic invertebrates, fish, amphibians revealed mortality developmental abnormalities in mosquito species exposed PPF-treated water. Moreover, may act an endocrine disruptor, hormonal pathways crucial for growth, reproduction, behavior Amphibians, instance, display altered reproductive physiology due disruptions signaling caused PPF. The ecological ramifications extend beyond direct toxicity Indirect include shifts food web dynamics ecosystem functioning. Reductions populations, induced PPF, can disrupt availability higher trophic levels, potentially destabilizing community structure equilibrium. Given mounting evidence consequences, robust risk assessment regulatory oversight are imperative. Accurate classification bodies is essential balancing role disease control pest management benefits need safeguard maintain health. Future research must prioritize comprehensive assessments PPF's across various habitats taxa inform evidence-based policymaking.

Language: Английский

Citations

Assessment of toxicity of pyriproxyfen, Bacillus thuringiensis, and malathion and their mixtures used for mosquito control on embryo-larval development and behavior of zebrafish DOI

Renata Meireles Oliveira Padilha,

Sâmara da Silva Gomes,

Jadson Freitas da Silva

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(30), P. 42672 - 42685

Published: June 14, 2024

Language: Английский

Citations

Acute toxicity of Trypsin Inhibitor from Tamarind seeds in embryo and adult zebrafish (Danio rerio) DOI

Yohanna Layssa dos Santos Melo,

Ana Carolina Luchiari,

Beatriz Silva Lopes

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101766 - 101766

Published: Oct. 10, 2024

The trypsin inhibitor isolated from tamarind seeds (TTI) is being investigated for potential applications in the treatment of noncommunicable diseases (NCD), such as hypertension, obesity, and diabetes. This study aimed to assess TTI embryotoxicity acute toxicity adult zebrafish (

Language: Английский

Citations

Effects of atrazine, diuron and glyphosate mixtures on zebrafish embryos: acute toxicity and oxidative stress responses DOI

Maria Eduarda Maia,

Rafael Xavier Martins,

Matheus Carvalho

et al.

Ecotoxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Language: Английский

Citations