The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory Animals DOI
Sounak Roy,

Mubeena Parveen,

Asis Bala

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

PBPK Modeling: Empowering Drug Development and Precision Dosing in China DOI Creative Commons
Dongsheng Yang, Jian Li, Wen Yao Mak

et al.

CPT Pharmacometrics & Systems Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling, a cornerstone of model‐informed drug development and precision dosing, simulates disposition in the human body by integrating physiological, biochemical, physicochemical parameters. While PBPK modeling has advanced globally since 1970s, China's adoption this technology followed distinctive path, characterized accelerated growth over past 2 decades. This review provides comprehensive analysis contributions to addressing knowledge gaps publication trends, application domains, platform preferences. A systematic literature search yielded 266 original research articles from PubMed up August 08, 2024. The revealed that drug–drug interaction studies constitute largest proportion analyses China. Chinese universities hospitals emerge as leading contributors among institutions Although established commercial such GastroPlus Simcyp remain popular within pharmaceutical industry, open‐source platforms like PK‐Sim are gaining significant traction applications across underscores transformative potential China, offering valuable insights into future directions challenges field.

Language: Английский

Citations

0
Modular dynamics paradigm in biosystems multilevel modeling: Software design and PBPK/PD validation DOI Creative Commons
Manuel Prado-Velasco

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 188, P. 109856 - 109856

Published: Feb. 21, 2025

Language: Английский

Citations

0
Determination of tricin in rat plasma by UPLC-MS/MS and its pharmacokinetics DOI
Congcong Wen,

Shunjun Ma,

Yi Zheng

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: 212, P. 113235 - 113235

Published: March 5, 2025

Language: Английский

Citations

0
The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory Animals DOI
Sounak Roy,

Mubeena Parveen,

Asis Bala

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0