Global progress and prospects of triclosan and triclocarban research in the environmental field: a bibliometric analysis and review DOI Creative Commons
Jie Han, Hui Chen,

Zhe Ren

et al.

Frontiers in Environmental Science, Journal Year: 2025, Volume and Issue: 13

Published: May 23, 2025

The widespread application of triclosan (TCS) and triclocarban (TCC) as antimicrobial agents has raised significant concerns among environmental scientists about their behavior, ecological effects, possible human health risks. To comprehensively understand the current research landscape developmental trends pertaining to TCS TCC in field, this study analyzed literature data from Web Science Core Collection (WOSCC) database 2002 2024 using advanced visualization tools such Bibliometrix, VOSviewer, Citespace. revealed that China dominates field with a publication count significantly higher than other countries, while Brazil India, developing nations, also make substantial contributions, ranking top 10 output. journals Total Environment , Chemosphere Environmental Technology featured highest number publications on topic. Keywords co-occurrence burst anlaysis contemporary predominantly concentrates behaviour fate these compounds, well ecotoxicological impacts mechanisms. Additionally, there is focused interest evaluating exposure risks investigating technologies for degradation removal. interaction compounds pollutants, along mechanisms, improvement removal technologies, are expected be key focal points forthcoming efforts. Based comprehensive bibliometric analysis, highlights critical need policies address persistence bioaccumulation potential TCC, urging development more effective strategies mitigate impacts, which could guide future regulatory frameworks.

Language: Английский

PBPK Modeling: Empowering Drug Development and Precision Dosing in China DOI Creative Commons
Dongsheng Yang, Jian Li, Wen Yao Mak

et al.

CPT Pharmacometrics & Systems Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling, a cornerstone of model‐informed drug development and precision dosing, simulates disposition in the human body by integrating physiological, biochemical, physicochemical parameters. While PBPK modeling has advanced globally since 1970s, China's adoption this technology followed distinctive path, characterized accelerated growth over past 2 decades. This review provides comprehensive analysis contributions to addressing knowledge gaps publication trends, application domains, platform preferences. A systematic literature search yielded 266 original research articles from PubMed up August 08, 2024. The revealed that drug–drug interaction studies constitute largest proportion analyses China. Chinese universities hospitals emerge as leading contributors among institutions Although established commercial such GastroPlus Simcyp remain popular within pharmaceutical industry, open‐source platforms like PK‐Sim are gaining significant traction applications across underscores transformative potential China, offering valuable insights into future directions challenges field.

Language: Английский

Citations

0
Modular dynamics paradigm in biosystems multilevel modeling: Software design and PBPK/PD validation DOI Creative Commons
Manuel Prado-Velasco

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 188, P. 109856 - 109856

Published: Feb. 21, 2025

Language: Английский

Citations

0
Determination of tricin in rat plasma by UPLC-MS/MS and its pharmacokinetics DOI
Congcong Wen,

Shunjun Ma,

Yi Zheng

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: 212, P. 113235 - 113235

Published: March 5, 2025

Language: Английский

Citations

0
The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory Animals DOI
Sounak Roy,

Mubeena Parveen,

Asis Bala

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Preclinical research has traditionally utilized laboratory animals to elucidate the safety, tolerability, pharmacokinetics, and pharmacodynamics of new chemical entities prior human trials. The use animal models been pivotal in advancing scientific knowledge medical breakthroughs, contributing significantly our understanding complex biological processes diseases. However, many promising treatments that have demonstrated efficacy studies failed translate subjects during clinical Consequently, testing faces ethical concerns criticism regarding its predictive reliability for responses. This led development 3R principles (Replacement, Reduction, Refinement), introduced 1959, advocating alternative methods improved welfare research. Furthermore, regulatory frameworks recent legislation, such as 2022 FDA Modernisation Act, emphasize modern alternatives traditional testing. Emerging approaches, known 3Cs-cell culture, computer simulation, phase 0 trials-offer nonanimal solutions could accelerate drug address concerns, potentially rendering preclinical more humane efficient.

Language: Английский

Citations

0
Global progress and prospects of triclosan and triclocarban research in the environmental field: a bibliometric analysis and review DOI Creative Commons
Jie Han, Hui Chen,

Zhe Ren

et al.

Frontiers in Environmental Science, Journal Year: 2025, Volume and Issue: 13

Published: May 23, 2025

The widespread application of triclosan (TCS) and triclocarban (TCC) as antimicrobial agents has raised significant concerns among environmental scientists about their behavior, ecological effects, possible human health risks. To comprehensively understand the current research landscape developmental trends pertaining to TCS TCC in field, this study analyzed literature data from Web Science Core Collection (WOSCC) database 2002 2024 using advanced visualization tools such Bibliometrix, VOSviewer, Citespace. revealed that China dominates field with a publication count significantly higher than other countries, while Brazil India, developing nations, also make substantial contributions, ranking top 10 output. journals Total Environment , Chemosphere Environmental Technology featured highest number publications on topic. Keywords co-occurrence burst anlaysis contemporary predominantly concentrates behaviour fate these compounds, well ecotoxicological impacts mechanisms. Additionally, there is focused interest evaluating exposure risks investigating technologies for degradation removal. interaction compounds pollutants, along mechanisms, improvement removal technologies, are expected be key focal points forthcoming efforts. Based comprehensive bibliometric analysis, highlights critical need policies address persistence bioaccumulation potential TCC, urging development more effective strategies mitigate impacts, which could guide future regulatory frameworks.

Language: Английский

Citations

0