Effect of per- and polyfluoroalkyl substances on neurodevelopment: Evidence-based risk assessment in the TRAEC strategy context DOI Creative Commons
Jie Ning,

Chaoshun Ding,

H. Zheng T. Xu

et al.

Environment International, Journal Year: 2024, Volume and Issue: unknown, P. 109003 - 109003

Published: Sept. 1, 2024

Although emerging evidence on the association between per- and polyfluoroalkyl substances (PFASs) neurodevelopment have been investigated, there is no consensus effect of maternal PFASs in offspring. Here, we assessed risk exposure offspring using a novel Targeted Risk Assessment Environmental Chemicals (TRAEC) strategy based multiple evidence. The from five online databases were analyzed neurodevelopment. potential was evaluated by TRAEC strategy, which conducted comprehensive scoring system with reliability, correlation, outcome fitness integrity. studies additional researchers' experiments included present study to proceed following assessment. Based framework evaluation health risks classified as low (absolute value 0-4), medium 4-8), high 8-10). In study, medium-risk level 5.61 overall risk-score. population-attributable (PAR) 8.26 % for exposure. identified low-risk prenatal ASD behavioral disabilities. chain length, type neurodevelopmental trajectories contributed Consistent results four criteria-based tools (ToxRTool, SciRAP, OHAT IRIS), assessment demonstrated robustness reliability study. These illustrated disorders addition, provided scientific structured method disorders, promoting consistency validation

Language: Английский

Identification and Characterization of Microplastics in Human Cervicovaginal Lavage Fluids Using Raman Spectroscopy: A Preliminary Study DOI Creative Commons
Young-Jun Shim, Hyun Jin Min

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 357 - 357

Published: Feb. 24, 2025

Microplastics have been detected in various human organs, and studies on their impact health are ongoing. However, few researched microplastics the cervicovaginal area. In this study, we aimed to assess presence lavage fluid. This prospective study was conducted at a single tertiary medical center, enrolling 10 participants aged 27–49 years. Human fluid samples were collected from patients by skilled obstetrician. Raman spectroscopy used analyze characterize microplastic particles samples. Ninety-one More than 50% of identified patient who regularly menstrual cups. The mean number 9.10 ± 14.96 per g sample. Most <50 μm size, polypropylene polystyrene most predominant types. analysis fluids, suggesting that area is exposed microplastics. varied significantly among individuals. highlights need for further research effects female reproductive system using

Language: Английский

Citations

0

Risk assessment of pyridaben exposure on neurodevelopment of offspring by using TRAEC strategy DOI Creative Commons
Shuangshuang Zhao, Qiaoqiao Xu, Yan Su

et al.

Sustainable Horizons, Journal Year: 2025, Volume and Issue: 13, P. 100135 - 100135

Published: March 1, 2025

Language: Английский

Citations

0

Effect of per- and polyfluoroalkyl substances on neurodevelopment: Evidence-based risk assessment in the TRAEC strategy context DOI Creative Commons
Jie Ning,

Chaoshun Ding,

H. Zheng T. Xu

et al.

Environment International, Journal Year: 2024, Volume and Issue: unknown, P. 109003 - 109003

Published: Sept. 1, 2024

Although emerging evidence on the association between per- and polyfluoroalkyl substances (PFASs) neurodevelopment have been investigated, there is no consensus effect of maternal PFASs in offspring. Here, we assessed risk exposure offspring using a novel Targeted Risk Assessment Environmental Chemicals (TRAEC) strategy based multiple evidence. The from five online databases were analyzed neurodevelopment. potential was evaluated by TRAEC strategy, which conducted comprehensive scoring system with reliability, correlation, outcome fitness integrity. studies additional researchers' experiments included present study to proceed following assessment. Based framework evaluation health risks classified as low (absolute value 0-4), medium 4-8), high 8-10). In study, medium-risk level 5.61 overall risk-score. population-attributable (PAR) 8.26 % for exposure. identified low-risk prenatal ASD behavioral disabilities. chain length, type neurodevelopmental trajectories contributed Consistent results four criteria-based tools (ToxRTool, SciRAP, OHAT IRIS), assessment demonstrated robustness reliability study. These illustrated disorders addition, provided scientific structured method disorders, promoting consistency validation

Language: Английский

Citations

1