Oxidative and Molecular–Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole DOI Creative Commons

Cristian Falero,

Wilfredo Huanca L., Manuel Barrios-Arpi

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 176 - 176

Published: Feb. 28, 2025

Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms. In present study, cytotoxic effect of triazole ipconazole was evaluated porcine and ram spermatozoa. Ipconazole significantly reduced sperm viability, increased ROS levels, altered catalase SOD enzyme activity, caused alterations molecular mRNA expression structural biomarkers (PRM1, ODF2, AKAP4, THEG, SPACA3 CLGN) related to fertility males, as well overexpression BAX (cell death) ROMO1 (oxidative stress) mRNA. Our results indicate that fungicide is involved cellular, enzymatic alteration spermatozoa, possibly a factor development infertility male mammals.

Language: Английский

Oxidative and Molecular–Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole DOI Creative Commons

Cristian Falero,

Wilfredo Huanca L., Manuel Barrios-Arpi

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 176 - 176

Published: Feb. 28, 2025

Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms. In present study, cytotoxic effect of triazole ipconazole was evaluated porcine and ram spermatozoa. Ipconazole significantly reduced sperm viability, increased ROS levels, altered catalase SOD enzyme activity, caused alterations molecular mRNA expression structural biomarkers (PRM1, ODF2, AKAP4, THEG, SPACA3 CLGN) related to fertility males, as well overexpression BAX (cell death) ROMO1 (oxidative stress) mRNA. Our results indicate that fungicide is involved cellular, enzymatic alteration spermatozoa, possibly a factor development infertility male mammals.

Language: Английский

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