The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia DOI Creative Commons
Hannah Gardener, Bonnie Levin, Kurunthachalam Kannan

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(5)

Published: May 1, 2025

Abstract Per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants. The neurotoxic cardiometabolic effects of PFAS well documented, leading to the hypothesis that exposure increases dementia risk. However, empirical data on in relation cognitive impairment weak, limited, inconsistent. This report reviews literature provides a rationale overview VascCog Longitudinal Study, new study using population‐based Northern Manhattan Study cohort, prospectively examine serum concentrations 13 lipids, carotid atherosclerosis, impairment, dementia. We hypothesize deleteriously impact cognition through pathway involving hyperlipidemia atherosclerosis. Rigorous examination is needed inform public health policies PFAS‐containing products, support regulations reduce community exposure, provide avenues protect at individual levels. Highlights risk factors neurotoxicity. Data controversial. mechanistic can policy.

Language: Английский

The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia DOI Creative Commons
Hannah Gardener, Bonnie Levin, Kurunthachalam Kannan

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(5)

Published: May 1, 2025

Abstract Per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants. The neurotoxic cardiometabolic effects of PFAS well documented, leading to the hypothesis that exposure increases dementia risk. However, empirical data on in relation cognitive impairment weak, limited, inconsistent. This report reviews literature provides a rationale overview VascCog Longitudinal Study, new study using population‐based Northern Manhattan Study cohort, prospectively examine serum concentrations 13 lipids, carotid atherosclerosis, impairment, dementia. We hypothesize deleteriously impact cognition through pathway involving hyperlipidemia atherosclerosis. Rigorous examination is needed inform public health policies PFAS‐containing products, support regulations reduce community exposure, provide avenues protect at individual levels. Highlights risk factors neurotoxicity. Data controversial. mechanistic can policy.

Language: Английский

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