Risk Assessment of Agricultural Plastic Films Based on Release Kinetics of Phthalate Acid Esters

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 55(6), P. 3676 - 3685

Published: Feb. 24, 2021

Plastic films have become an integral part of fruit and vegetable production systems, but their release phthalate acid esters (PAEs) is a threat to human health. The kinetics PAEs measures risk are still not well understood. We investigated 50 agricultural films, with concentrations ranging from 2.59 282,000 mg kg–1. seven commercially available film types included were polyvinylchloride (PVC), metallocene polyethylene (mPE), ethylene vinyl acetate (EVA), polyolefin (PO), three mulch films. Bis(2-ethylhexyl) (DEHP) was detected in most its fitted into the first-order kinetic model. rate DEHP negatively related thickness. potential carcinogenic risks air six kinds plastic greenhouses health estimated. found that associated PVC mPE greenhouse warrant greater attention. Though EVA, PO greenhouse, lower risk, we advise keeping ventilated during first month use reduce direct exposure volatile PAEs.

Language: Английский

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A critical review on human internal exposure of phthalate metabolites and the associated health risks

Environmental Pollution, Journal Year: 2021, Volume and Issue: 279, P. 116941 - 116941

Published: March 13, 2021

Language: Английский

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Phthalates’ exposure leads to an increasing concern on cardiovascular health

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 457, P. 131680 - 131680

Published: May 23, 2023

Being an essential component in the plastics industry, phthalates are ubiquitous environment and everyday life. They considered environmental contaminants that have been classified as endocrine-disrupting compounds. Despite di-2-ethylhexyl phthalate (DEHP) being most common plasticizer studied to date, there many others that, addition widely used plastic, also applied medical pharmaceutical industries cosmetics. Due their wide use, easily absorbed by human body where they can disrupt endocrine system binding molecular targets interfering with hormonal homeostasis. Thus, exposure has implicated development of several diseases different age groups. Collecting information from recent available literature, this review aims relate phthalates’ cardiovascular throughout all ages. Overall, studies presented demonstrated association between diseases, either prenatal or postnatal exposure, affecting foetuses, infants, children, young older adults. However, mechanisms underlying these effects remain poorly explored. considering incidence worldwide constant phthalates, topic should be extensively understand involved.

Language: Английский

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After effects of Pharmaceuticals and Personal Care Products (PPCPs) on the biosphere and their counteractive ways

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 342, P. 126921 - 126921

Published: Feb. 27, 2024

Language: Английский

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Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages

Environment International, Journal Year: 2024, Volume and Issue: 184, P. 108415 - 108415

Published: Jan. 8, 2024

An increasing number of harmful environmental factors are causing serious impacts on human health, and there is an urgent need to accurately identify the toxic effects mechanisms these factors. However, traditional toxicity test methods (e.g., animal models cell lines) often fail provide accurate results. Fortunately, organoids differentiated from stem cells can more accurately, sensitively specifically reflect body. They also suitable for specific studies frequently used in toxicology nowadays. As a combination organ-on-a-chip technology, organoids-on-a-chip has great potential toxicology. It controllable physicochemical microenvironment not easy be contaminated. higher homogeneity size shape organoids. In addition, it achieve vascularization exchange nutrients metabolic wastes time. Multi-organoids-chip simulate interactions different organs. These advantages facilitate better function maturity organoids, which make up shortcomings common certain extent. This review firstly discussed limitations testing platforms, leading introduction new platforms: organoids-on-a-chip. Next, applications were summarized prospected. Since platforms have been sufficiently considered previous literature, we particularly emphasized them. Finally, this opportunities challenges faced by organoids-on-a-chip, with expectation that readers will gain deeper understanding their value field

Language: Английский

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Fetal–Maternal Exposure to Endocrine Disruptors: Correlation with Diet Intake and Pregnancy Outcomes

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1744 - 1744

Published: June 11, 2020

Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs found in several everyday products including plastic bottles food containers they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding effects EDCs, particularly Bisphenol A (BPA) phthalates, on human pregnancy fetal development. Several evidence obtained vitro animal models well epidemiologic population studies strongly indicated that disruptors negatively impact placental health interfering embryonic developing epigenome, establishing disease paths into adulthood. Moreover, cause and/or contribute onset severe gestational conditions Preeclampsia (PE), Fetal Growth Restriction (FGR) diabetes pregnancy, obesity, cardiovascular complications reproductive age. Therefore, despite contrasting data being present literature, must considered a therapeutic target. Future actions aimed at reducing eliminating EDC exposure during perinatal period mandatory guarantee success preserve adult health.

Language: Английский

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Phthalates, bisphenols, parabens, and triclocarban in feminine hygiene products from the United States and their implications for human exposure

Environment International, Journal Year: 2020, Volume and Issue: 136, P. 105465 - 105465

Published: Jan. 13, 2020

Feminine hygiene products, a category of daily necessities, can be source exposure to plasticizers and antimicrobial agents in women. Nevertheless, studies on the occurrence chemicals feminine products have received little attention. In this study, 24 endocrine-disrupting (EDCs), comprising nine phthalates, six parabens, eight bisphenols, triclocarban (TCC) were measured seven categories (i.e., pads, panty liners, tampons, wipes, bactericidal creams solutions, deodorant sprays powders; N = 77) collected Albany area New York State United States. Dimethyl phthalate (DMP), diethyl (DEP), dibutyl (DBP), di-iso-butyl (DIBP), di(2-ethylhexyl) (DEHP), methyl paraben (MeP), ethyl (EtP) found all pad, liner, tampon samples. Panty liners contained highest concentrations DMP (median: 249 ng/g), DEP (386 DBP (393 DIBP (299 ng/g) tampons DEHP (267 ng/g). MeP, EtP, propyl (PrP) major parabens products. Bactericidal solutions median EtP PrP at 2840, 734, 278 ng/g, respectively. The estimated doses bisphenols through dermal absorption pathway from use significant. comparison with reported previously other sources pathways, significance as EDC was delineated. under different scenarios, 0.19-27.9% 0.01-6.2% total phthalates This is first study report TCC

Language: Английский

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Phthalate exposure and allergic diseases: Review of epidemiological and experimental evidence

Environment International, Journal Year: 2020, Volume and Issue: 139, P. 105706 - 105706

Published: May 1, 2020

Phthalates are among the most ubiquitous environmental contaminants and endocrine-disrupting chemicals. Exposure to phthalates related health effects have been extensively studied over past four decades. An association between phthalate exposure allergic diseases has suggested, although literature is far from conclusive. This article reviews evaluates epidemiological (n = 43), animal 49), cell culture studies 42), published until end of 2019, on diseases, such as asthma, rhinoconjunctivitis, eczema. In contrast earlier reviews, emphasis placed experimental that use concentrations with relevance for human exposure. Epidemiological provide support associations exposures airway, nasal, ocular, dermal disease outcomes, reported significant tend be weak demonstrate inconsistencies any given phthalate. Rodent may act adjuvants at levels likely relevant exposures, inducing respiratory inflammatory in presence an allergen. Cell alter functionality innate adaptive immune cells. However, due limitations applied methods models studies, including diversity phthalates, routes, considered, provided findings fragmented. Nevertheless, current evidence points direction concern. Further research warranted identify critical windows exposure, importance pathways, interactions social factors, co-exposure other contaminants.

Language: Английский

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Recent Attempts in the Design of Efficient PVC Plasticizers with Reduced Migration

Materials, Journal Year: 2021, Volume and Issue: 14(4), P. 844 - 844

Published: Feb. 10, 2021

This paper reviews the current trends in replacing commonly used plasticizers poly(vinyl chloride), PVC, formulations by new compounds with reduced migration, leading to enhancement mechanical properties and better plasticizing efficiency. Novel have been divided into three groups depending on replacement strategy, i.e., total replacement, partial internal plasticizers. Chemical physical of PVC containing a wide range compared, allowing observance improvements polymer performance comparison plasticized conventionally applied bis(2-ethylhexyl) phthalate, di-n-octyl terephthalate terephthalate. Among variety newly developed plasticizers, we indicated those presenting excellent migration resistance advantageous properties, as well derived from natural sources. A separate chapter has dedicated description synergistic effect mixture two primary secondary, that benefits suppression when secondary plasticizer is added blend.

Language: Английский

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Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

Nutrients, Journal Year: 2020, Volume and Issue: 12(2), P. 525 - 525

Published: Feb. 19, 2020

Endocrine-disrupting chemicals (EDCs) are exogenous substances that able to interfere with hormone action, likely contributing the development of several endocrine and metabolic diseases. Among them, Bisphenol A (BPA) phthalates contaminate food water have been largely studied as obesogenic agents. They might contribute weight gain, insulin resistance pancreatic β-cell dysfunction in pregnancy, potentially playing a role pregnancy complications, such gestational diabetes mellitus (GDM), adverse outcomes. Pregnancy childhood sensitive windows susceptibility, and, although not univocal results, preclinical clinical studies suggested exposure BPA at these stages life an impact on diseases even many years later. The molecular mechanisms underlying this association unknown, but adipocyte suspected be involved. Remarkably, transgenerational damage has observed, which explained by epigenetic changes. Further research is needed address knowledge gaps provide preventive measure limit health risks connected EDCs.

Language: Английский

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