Nutrients,
Journal Year:
2021,
Volume and Issue:
13(7), P. 2358 - 2358
Published: July 9, 2021
Infants
and
toddlers
are
highly
sensitive
to
contaminants
in
food.
Chronic
exposure
can
lead
developmental
delays,
disorders
of
the
nervous,
urinary
immune
systems,
cardiovascular
disease.
A
literature
review
was
conducted
mainly
PubMed,
Google
Scholar
Scopus
databases,
took
into
consideration
papers
published
from
October
2020
March
2021.
We
focused
on
contaminant
content,
intake
estimates,
most
commonly
found
foods
consumed
by
infants
children
aged
0.5-3
years.
In
review,
we
included
83
publications
with
full
access.
Contaminants
that
pose
a
high
health
risk
toxic
elements,
acrylamide,
bisphenol,
pesticide
residues.
Minor
pollutants
include:
dioxins,
mycotoxins,
nitrates
nitrites,
polycyclic
aromatic
hydrocarbons.
order
reduce
negative
effects
food
contamination,
it
seems
reasonable
educate
parents
limit
potentially
dangerous
for
young
children.
An
appropriate
varied
diet,
selected
cooking
techniques,
proper
preparation
increase
likelihood
consume
safe
their
health.
It
is
necessary
monitor
adhere
standards
at
every
stage
production,
improve
quality
Toxics,
Journal Year:
2022,
Volume and Issue:
10(8), P. 472 - 472
Published: Aug. 13, 2022
Dietary
assessment
reports
and
population
surveillance
programs
show
that
chronic
exposure
to
low
levels
of
environmental
cadmium
(Cd)
is
inevitable
for
most
people,
adversely
impacts
the
health
children
adults.
Based
on
a
risk
model
considers
an
increase
in
excretion
β2-microglobulin
(β2M)
above
300
μg/g
creatinine
be
“critical”
toxicity
endpoint,
tolerable
intake
level
Cd
was
set
at
0.83
µg/kg
body
weight/day,
urinary
rate
5.24
µg/g
considered
threshold
level.
The
aim
this
review
draw
attention
many
other
endpoints
are
both
clinically
relevant
more
appropriate
derive
limits
than
β2M
endpoint.
In
present
review,
we
focus
reduction
glomerular
filtration
diminished
fecundity
because
low-dose
Cd,
reflected
by
its
as
0.5
creatinine,
have
been
associated
with
dose-dependent
increases
these
pathological
symptoms.
Some
protective
effects
nutritionally
essential
elements
selenium
zinc
highlighted.
Cd-induced
mitochondrial
dysfunction
discussed
potential
mechanism
underlying
gonadal
toxicities
infertility.
Journal of Applied Toxicology,
Journal Year:
2023,
Volume and Issue:
44(1), P. 129 - 147
Published: Aug. 16, 2023
Abstract
Cadmium
(Cd)
is
a
ubiquitous
heavy
metal
toxicant
with
no
biological
function
in
the
human
body.
Considerably,
because
of
its
long
half‐life
and
very
low
excretion
rate,
Cd
inclined
to
accumulate
cause
deleterious
effects
on
various
body
organs
(e.g.,
liver,
kidney,
ovary)
humans
animals.
Ovaries
are
most
vulnerable
targets
toxicity.
has
been
shown
induce
oxidative
stress,
follicular
atresia,
hormonal
imbalance,
impairment
oocyte
growth
development.
Moreover,
toxicity
associated
increasing
incidences
menstrual
disorders,
pregnancy
loss,
preterm
births,
delayed
puberty,
female
infertility.
Therefore,
it
crucial
understand
how
poisoning
impacts
specific
ovarian
processes
for
development
preventive
interventions
enhance
fertility.
The
current
review
attempts
collate
recent
findings
Cd‐induced
apoptosis,
steroid
synthesis
inhibition,
teratogenic
toxicity,
along
their
possible
mechanisms
tissue
different
animal
species.
Additionally,
also
summarizes
studies
related
use
many
antioxidants,
medicinal
herbs,
other
compounds
as
remedial
approaches
managing
Environmental Toxicology,
Journal Year:
2024,
Volume and Issue:
39(5), P. 2502 - 2511
Published: Jan. 5, 2024
Abstract
The
purpose
of
this
study
was
to
explore
the
effects
combined
lead
(Pb)
and
two
types
microplastic
(MP)
(polyvinyl
chloride
[PVC]
polyethylene
[PE])
exposure
on
glucose
metabolism
investigate
role
nuclear
factor
erythroid
2‐related
2
(Nrf2)/nuclear
factor‐kappa
B
(NF‐κB)
signaling
pathway
in
mediating
these
mice.
Adult
C57BL/6J
mice
were
randomly
divided
into
four
groups:
control,
Pb
(100
mg/L),
MPs
(containing
10
mg/L
PE
PVC),
+
MPs,
each
which
treated
with
drinking
water.
Treatments
conducted
for
6
weeks.
Co‐exposure
exhibited
increase
glycosylated
serum
protein
levels,
insulin
resistance,
damaged
tolerance
compared
control
Additionally,
treatment
caused
more
severe
damage
hepatocytes
than
when
exposed
them
alone
concomitantly,
improved
levels
interleukin‐6,
tumor
necrosis
factor‐alpha,
malondialdehyde,
but
reduced
superoxide
dismutase,
glutathione
peroxidase,
catalase
assay
livers.
Furthermore,
they
Kelch‐like
ECH‐associated
1
(Keap1)
phosphorylated
p‐NF‐κB
heme
oxygenase‐1
Nrf2,
as
well
increased
Keap1
mRNA
Nrf2
mRNA.
MP
impacts
via
/NF‐κB
pathway.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(7), P. 2358 - 2358
Published: July 9, 2021
Infants
and
toddlers
are
highly
sensitive
to
contaminants
in
food.
Chronic
exposure
can
lead
developmental
delays,
disorders
of
the
nervous,
urinary
immune
systems,
cardiovascular
disease.
A
literature
review
was
conducted
mainly
PubMed,
Google
Scholar
Scopus
databases,
took
into
consideration
papers
published
from
October
2020
March
2021.
We
focused
on
contaminant
content,
intake
estimates,
most
commonly
found
foods
consumed
by
infants
children
aged
0.5-3
years.
In
review,
we
included
83
publications
with
full
access.
Contaminants
that
pose
a
high
health
risk
toxic
elements,
acrylamide,
bisphenol,
pesticide
residues.
Minor
pollutants
include:
dioxins,
mycotoxins,
nitrates
nitrites,
polycyclic
aromatic
hydrocarbons.
order
reduce
negative
effects
food
contamination,
it
seems
reasonable
educate
parents
limit
potentially
dangerous
for
young
children.
An
appropriate
varied
diet,
selected
cooking
techniques,
proper
preparation
increase
likelihood
consume
safe
their
health.
It
is
necessary
monitor
adhere
standards
at
every
stage
production,
improve
quality
