Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Molecules, Journal Year: 2022, Volume and Issue: 27(14), P. 4523 - 4523

Published: July 15, 2022

Cancer has been a serious public health problem. Berberine is famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, antimicrobial activities. In addition, berberine anticancer effects on variety of cancers, breast, lung, gastric, liver, colorectal, ovarian, cervical, prostate cancers. The underlying mechanisms action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, improving the drugs. This paper summarizes effectiveness different cancers highlights action. nanotechnologies to improve bioavailability are included. Moreover, side also discussed. helpful for prevention treatment using berberine.

Language: Английский

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Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy

Molecules, Journal Year: 2022, Volume and Issue: 27(4), P. 1192 - 1192

Published: Feb. 10, 2022

Despite significant advances in early diagnosis and treatment, cancer is one of the leading causes death. Photodynamic therapy (PDT) a for treatment many diseases, including cancer. This uses combination photosensitizer (PS), light irradiation appropriate length molecular oxygen. The photodynamic effect kills cells through apoptosis, necrosis, or autophagy tumor cells. PDT promising approach eliminating various cancers but not yet as widely applied conventional chemotherapy. Currently, natural compounds with photosensitizing properties are being discovered identified. A reduced toxicity to healthy tissues lower incidence side effects inspires scientists seek PS PDT. In this review, several groups photoactive presented. use products has been shown be fruitful discovery novel pharmaceuticals. review focused on anticancer activity furanocoumarins, polyacetylenes, thiophenes, tolyporphins, curcumins, alkaloid anthraquinones relation light-absorbing properties. Attention will paid their phototoxic anti-cancer types

Language: Английский

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The Janus face of mitophagy in myocardial ischemia/reperfusion injury and recovery

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116337 - 116337

Published: Feb. 28, 2024

In myocardial ischemia/reperfusion injury (MIRI), moderate mitophagy is a protective or adaptive mechanism because of clearing defective mitochondria accumulates during MIRI. However, excessive lead to an increase in and ultimately exacerbate MIRI by causing overproduction uncontrolled production mitochondria. Phosphatase tensin homolog (PTEN)-induced kinase 1 (Pink1), Parkin, FUN14 domain containing (FUNDC1) B-cell leukemia/lymphoma 2 (BCL-2)/adenovirus E1B19KD interaction protein 3 (BNIP3) are the main mechanistic regulators Pink1 Parkin mitochondrial surface proteins involved ubiquitin-dependent pathway, while BNIP3 FUNDC1 receptor non-ubiquitin-dependent which play crucial role maintaining homeostasis quality. These can induce inhibit protect against but may also trigger insufficient mitophagy, thereby worsening condition. Understanding actions these provide valuable insights into pathological mechanisms underlying development. Based on above background, this article reviews through Pink1/Parkin pathway mediated led BNIP3, as well related drug treatment, aim effective strategies for prevention treatment

Language: Английский

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Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 229 - 255

Published: Sept. 1, 2024

Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.

Language: Английский

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Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

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Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 15, 2021

Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed its therapeutic effects. However, as for berberine’s metabolites, especially phase II pharmacokinetics excretion were rarely reported. The objective of this study was thoroughly investigate pharmacokinetic profiles nine namely, berberrubine (M1), demethyleneberberine (M2), jatrorrhizine (M3), jatrorrhizine-3- O-β -D-glucuronide (M4), O -sulfate (M5), thalfendine-10- (M6), berberrubine-9- (M7), demethyleneberberine-2- (M8) (M9) in rats. An accurate reliable LC-MS/MS method developed validated determination rat biosamples. Pharmacokinetic obtained after single intravenous administration (4.0 mg/kg) oral (48.2, 120 or 240 For study, rats intragastrically administered dose 48.2 mg/kg berberine. Our results showed rapidly all detected vivo . absolute bioavailability 0.37 ± 0.11%. As AUC 0–48 h values, much higher than those I suggesting major exist blood circulation. 18.6% excreted feces (M1). total recovery from urine, bile 41.2%. This is first systematic about which will beneficial both better understanding clinical effects further development

Language: Английский

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Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Plants, Journal Year: 2021, Volume and Issue: 10(12), P. 2762 - 2762

Published: Dec. 14, 2021

The large-scale production of plant-derived secondary metabolites (PDSM) in bioreactors to meet the increasing demand for bioactive compounds treatment and prevention degenerative diseases is nowadays considered an engineering challenge due large number operational factors that need be during their design scale-up. plant cell suspension culture (CSC) has presented numerous benefits over other technologies, such as conventional whole-plant extraction, not only avoiding overexploitation species, but also achieving better yields having excellent scaling-up attributes. selection bioreactor configuration depends on intrinsic properties considerations related effect operating conditions thermodynamics, kinetics, transport phenomena, which together are essential accomplishing PDSM. To this end, review, firstly, provides a comprehensive appraisement PDSM, essentially those with demonstrated importance utilization pharmaceutical industries. Then, special attention given PDSM obtained out CSC. Finally, aspects CSC stating kinetics phenomena and, hence, viability accordingly. analysis reviewed configurations will pave way future research focused scaling up, produce high value-added

Language: Английский

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Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 5889 - 5889

Published: Sept. 10, 2022

Cancer is the most commonly diagnosed type of disease and a major cause death worldwide. Despite advancement in various treatment modules, there has been little improvement survival rates side effects associated with this disease. Medicinal plants or their bioactive compounds have extensively studied for anticancer potential. Novel drugs based on natural products are urgently needed to manage cancer through attenuation different cell signaling pathways. In regard, berberine alkaloid that found variety plants, an inverse association revealed between its consumption cancer. Berberine exhibits role scavenging free radicals, induction apoptosis, cycle arrest, inhibition angiogenesis, inflammation, PI3K/AKT/mammalian target rapamycin (mTOR), Wnt/β-catenin, MAPK/ERK pathway. addition, synergistic proven several cancers. This review outlines mechanisms action cancers modulation Moreover, recent developments drug delivery systems effect explained.

Language: Английский

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Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease

Molecules, Journal Year: 2022, Volume and Issue: 27(4), P. 1351 - 1351

Published: Feb. 17, 2022

In recent years, the health of patients exposed to consequences metabolic syndrome still requires search for new solutions, and plant nutraceuticals are currently being intensively investigated. Berberine is a alkaloid possessing scientifically determined mechanisms prevention development atherosclerosis, type 2 diabetes, obesity, as well cardiovascular complications cancer. It positively contributes elevated levels fasting, postprandial blood glucose, glycosylated hemoglobin, while decreasing insulin resistance. stimulates glycolysis, improving secretion, inhibits gluconeogenesis adipogenesis in liver; by reducing resistance, berberine also improves ovulation. The anti-obesity action has been well-documented. acts an anti-sclerotic, lowering LDL testosterone levels. exhibits anti-inflammatory property stalling expression cyclooxygenase (COX-2) prostaglandin E2. neuroprotective antidepressive. However, outcomes psychiatric nonspecific, it shown that parameters schizophrenic patients, acting adjuvant during antipsychotic treatment. anticancer option inducing apoptosis, cell cycle arrest, influencing MAPK (mitogen-activated protein kinase), transcription regulation. inhibition carcinogenesis combined with lipid metabolism.

Language: Английский

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Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends

Molecules, Journal Year: 2022, Volume and Issue: 27(12), P. 3705 - 3705

Published: June 9, 2022

Traditionally, herbal compounds have been the focus of scientific interest for last several centuries, and continuous research into their medicinal potential is underway. Berberine (BBR) an isoquinoline alkaloid extracted from plants that possess a broad array properties, including anti-diarrheal, anti-fibrotic, antidiabetic, anti-inflammatory, anti-obesity, antihyperlipidemic, antihypertensive, antiarrhythmic, antidepressant, anxiolytic effects, frequently utilized as traditional Chinese medicine. BBR promotes metabolisms glucose lipids by activating adenosine monophosphate-activated protein kinase, stimulating glycolysis inhibiting functions mitochondria; all these ameliorate type 2 diabetes mellitus. has also shown to benefits in congestive heart failure, hypercholesterolemia, atherosclerosis, non-alcoholic fatty liver disease, Alzheimer’s polycystic ovary syndrome. investigated interesting pharmacophore with contribute significantly development novel therapeutic medicines variety disorders. Despite its enormous promise, clinical application this was severely limited because unpleasant pharmacokinetic characteristics. Poor bioavailability, absorption, poor water solubility are some obstacles restricted use. Nanotechnology suggested possible solution problems. The present review aims at recent updates on important activities different types nanocarriers used delivery diseases.

Language: Английский

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