Tropane alkaloids in food DOI Creative Commons
Andrea Lugasi

Élelmiszervizsgálati Közlemények, Journal Year: 2023, Volume and Issue: 69(1), P. 4317 - 4336

Published: March 31, 2023

Tropane alkaloids occur in many plant families and their toxic effects can cause mild symptoms or even death, depending on the dose. They are most commonly introduced into human body through contamination, misuse deliberate abuse due to intoxicating effects. present food for general consumption, sometimes causing documented poisoning, inadequate cleaning of cereals, pulses other grain crops, but especially organic products produced without chemicals. The EU legislation published 2021 set tolerances tropane a relatively wide range materials, therefore consistent compliance with regulation will reduce safety risk from alkaloid although poisoning incidents recent years have highlighted need broaden substances covered.

Language: Английский

Occurrence and Chemistry of Tropane Alkaloids in Foods, with a Focus on Sample Analysis Methods: A Review on Recent Trends and Technological Advances DOI Creative Commons
Lorena González-Gómez, Sonia Morante‐Zarcero, Damián Pérez‐Quintanilla

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(3), P. 407 - 407

Published: Jan. 30, 2022

Tropane alkaloids (TAs) are natural toxins produced by different plants, mainly from the Solanaceae family. The interest in TAs analysis is due to serious cases of poisoning that presence TA-producing plants a variety foods. For this reason, recent years, analytical methods have been reported for their control. However, complexity matrices makes sample preparation critical step task. Therefore, review has focused on (a) collecting available data relation occurrence foods human consumption and (b) providing state art food (from 2015 today). Regarding categories, cereals related products teas herbal most analyzed. Solid-liquid extraction still technique widely used preparation, although other purification techniques such as solid-phase or QuEChERS procedure, based use sorbents extract clean-up step, being applied since they allow cleaner extracts. On hand, new materials (molecularly imprinted polymers, mesostructured silica-based materials, metal-organic frameworks) emerging develop effective lower limits matrix effects, future trend TAs.

Language: Английский

Citations

51
Insight into the Impact of Food Processing and Culinary Preparations on the Stability and Content of Plant Alkaloids Considered as Natural Food Contaminants DOI Creative Commons
Natalia Casado, Gema Casado-Hidalgo, Lorena González-Gómez

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 1704 - 1704

Published: Jan. 29, 2023

Pyrrolizidine alkaloids, tropane alkaloids and opium are natural plant toxins that have recently gained special interest in food safety due to their concerning occurrence many foods feeds. Although a legislation for these has been established, the concentration levels of exceed cases maximum limit established by competent authorities. Moreover, regulations only establish limits compounds certain raw materials, but processed products generally not considered. However, it is important correctly assess potential health risk through diet. Accordingly, this review aims provide insight into give an overview on how processing culinary preparation can influence content stability. For purpose, most relevant works address effect heat treatment, fermentation, infusion (transfer rate) other treatments (milling, washing soaking) reviewed. To date, research field scarcely studied results published contradictory, so always possible conclusive findings. In cases, lack experimental design exhaustive control different variables may affect preparations. Likewise, considering transformation toxic degradation also high interest. Therefore, further studies needed delve deeper stability understand be affected contaminated materials products, exposure population diet determined more precisely. Hence, topic constitutes line great future with challenges resolved.

Language: Английский

Citations

21
Recent food alerts and analytical advances related to the contamination of tropane and pyrrolizidine alkaloids in food DOI Creative Commons
Natalia Casado, Judith Gañán, Sonia Morante‐Zarcero

et al.

Frontiers in Chemical Biology, Journal Year: 2024, Volume and Issue: 3

Published: April 10, 2024

The food control of tropane and pyrrolizidine alkaloids has become in recent years Europe one the main priorities within safety field due to exponential increase alerts related concerning levels these natural toxins foods. This awareness led increasing progress research determination compounds. Hence, this mini-review provides a brief comprehensive overview evolution alerts, highlighting products frequently contaminated with reviewing analytical advances their las 3 (from 2020 2023).

Language: Английский

Citations

4
Exploring Adsorption Performance of Functionalized Mesoporous Silicas with a Different Pore Structure as Strong Cation-Exchange Sorbents for Solid-Phase Extraction of Atropine and Scopolamine DOI Creative Commons
Fernando L. Vera-Baquero, Sonia Morante‐Zarcero, Damián Pérez‐Quintanilla

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 646 - 646

Published: Jan. 10, 2025

In this work, mesoporous silicas with two types of structures were synthesized and functionalized sulfonic acid groups: MCM-41-SO3H (honeycomb-like hexagonal structure) MSU-2-SO3H (three-dimensional porous structure wormhole pores). The materials characterized by X-ray diffraction, transmission electron microscopy, scanning nitrogen adsorption–desorption, Fourier-transform infrared spectroscopy, 29Si solid-state nuclear magnetic resonance elemental analysis. obtained evaluated as sorbents for strong cation-exchange solid-phase extraction (SPE) to determine their efficiency in the adsorption desorption tropane alkaloids (atropine scopolamine). loading solvents, volume, analyte concentration, elution volume studied, using 50 mg both materials. Analyses carried out ultra-high performance liquid chromatography coupled triple quadrupole tandem mass spectrometry. material presented highest recovery has proven be a promising sorbent SPE atropine scopolamine aqueous media. high degree functionalization accessibility groups target analytes, due regularity uniformity pores, maximize contact between sorbent, favoring efficient adsorption.

Language: Английский

Citations

0
Advances in Greener and Sustainable Sample Preparation for Tropane Alkaloid Analysis in Foods DOI
Lorena González-Gómez, Begoña Fernández-Pintor, Judith Gañán

et al.

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: Jan. 1, 2025

Language: Английский

Citations

0
Spherical C18-functionalized ordered mesoporous silica packed on micro-solid phase extraction cartridges for simultaneous determination of twenty-three alkaloids in flower extract supplements DOI Creative Commons
Begoña Fernández-Pintor, Judith Gañán, Damián Pérez‐Quintanilla

et al.

Advances in Sample Preparation, Journal Year: 2025, Volume and Issue: unknown, P. 100174 - 100174

Published: March 1, 2025

Language: Английский

Citations

0
Alkaloids' wide world: Biological activity, extraction, quantification DOI
Adriana Arigò,

Genny Grasselli

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 337 - 369

Published: Jan. 1, 2025

Language: Английский

Citations

0
Ordered Mesoporous Silicas in Modern Versions of Solid-Phase Extraction DOI

A. S. Zavalyueva,

С. И. Карпов,

Nataliya Zatonskaya

et al.

Journal of Analytical Chemistry, Journal Year: 2025, Volume and Issue: 80(1), P. 1 - 14

Published: Jan. 1, 2025

Language: Английский

Citations

0
Atropine and scopolamine occurrence in spices and fennel infusions DOI Creative Commons
Lorena González-Gómez, Judith Gañán, Sonia Morante‐Zarcero

et al.

Food Control, Journal Year: 2022, Volume and Issue: 146, P. 109555 - 109555

Published: Dec. 3, 2022

Tropane alkaloids (TAs) are toxic anticholinergic compounds that appear due to accidental contamination of foods with TA-producing plants. Atropine and scopolamine the most common TAs their maximum levels in certain foodstuffs have been recently regulated, including food supplements. occurrence commercial products transfer ratio herbal infusions prepared from contaminated spices interest for exposure assessment consumers. In this study, atropine was investigated a total 51 6 types (ginger, cloves, fennel, cumin, aniseed, coriander) mix herbs (curry) purchased Portugal (19 samples) Spain (32 2021. Results evidenced more than half samples analysed (67%) were one or both analytes. Fennel, cloves coriander showed highest concentrations ranging between 5-31 μg/kg, 8–28 μg/kg 5–45 respectively, sum scopolamine. On other hand, target analytes found four naturally fennel studied. Infusions according International Standard ISO 3103 protocol, 64 88% 47 57% found.

Language: Английский

Citations

16
Chiral HPLC-MS/MS determination of hyoscyamine enantiomers in baby herbal infusions after preconcentration with sulfonic HMS mesostructured silica synthesized by co-condensation DOI Creative Commons
Fernando L. Vera-Baquero, Judith Gañán, Sonia Morante‐Zarcero

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 198, P. 110150 - 110150

Published: Feb. 13, 2024

Tropane alkaloids are considered a major food safety issue in recent years, due to their worrying appearance many foods, such as herbal infusions, usually cross-contamination with weeds during harvest. (−)-Hyoscyamine is synthesized by tropane alkaloids-producing plants and its ingestion can cause all types of disorders humans. Its enantiomerization occurs easily over time, so the inactive (+)-hyoscyamine be found foods variable proportions. Therefore, goal current work was develop chiral high performance liquid chromatography tandem mass spectrometry method for enantiomeric determination (−)- (+)-hyoscyamine. Chromatographic separation optimized, best resolution (Rs = 1.59) achieved 6.5 min Chiralpak® AY-3 polysaccharide-based stationary phase column using ethanol 0.05 % diethylamine mobile phase. For preconcentration sample, two mesostructured silicas sulfonic groups were synthesized, grafting co-condensation methods, characterized. The materials evaluated sorbents strong-cation exchange solid-phase extraction hyoscyamine baby infusions. Based on findings gathered, silica denoted HMS-SO3−(co) sorbent number functional attached (2.63 mmol/g) textural properties. Under optimal conditions, factor obtained 167, only 50 mg material, very low racemization (−)-hyoscyamine (+) enantiomer (<20 %). validated recoveries 94–99 %, good linearity (R2 > 0.99), precision (RSD < 20 %), no matrix effect both analytes quantification limit (0.089 µg/L 0.092 (−)-hyoscyamine, respectively) meet applicability monitoring real samples. Two teas babies (instant tea bags) analyzed developed methodology. instantaneous infusions analysed contaminated, one them 0.21 0.09 (ratio 70(−)/30(+)) other 0.075 (the (+)- below method). Taking these results into account, it important evaluate content enantiomers avoid overestimation exposure.

Language: Английский

Citations

3