Integrated oral microgel system ameliorates renal fibrosis by hitchhiking co-delivery and targeted gut flora modulation DOI Creative Commons
Yu Hou, Lin Zhu, Xiaofeng Ye

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 1, 2024

Abstract Background Renal fibrosis is a progressive process associated with chronic kidney disease (CKD), contributing to impaired function. Active constituents in traditional Chinese herbs, such as emodin (EMO) and asiatic acid (AA), exhibit potent anti-fibrotic properties. However, the oral administration of EMO AA results low bioavailability limited accumulation. Additionally, while probiotics have been accepted for CKD treatment through gut microbiota modulation, significant challenge lies ensuring their viability upon administration. Therefore, our study aims address both renal imbalance innovative co-delivery strategies. Results In this study, we developed yeast cell wall particles (YCWPs) encapsulating self-assembled nanoparticles (NPYs) embedded them, along Lactobacillus casei Zhang, chitosan/sodium alginate (CS/SA) microgels. The microgels showed controlled release properties loaded NPYs prolonged retention time Zhang ( L. Zhang) intestine. Furthermore, vivo biodistribution that microgel-carried significantly accumulated obstructed kidneys rats, thereby substantially increasing accumulation kidneys. More importantly, hitchhiking delivery based on positive modulation microbiota, synergistic strategy therapeutic modulatory interactions could regulate TGF-β/Smad signaling pathway thus effectively ameliorate unilateral ureteral obstruction (UUO) rats. Conclusion conclusion, work provides new nanodrugs achieve effects targeted flora modulation. Graphical

Language: Английский

FTZ polysaccharides ameliorate kidney injury in diabetic mice by regulating gut-kidney axis DOI
Tian Lan, Tang Tang, Ying Li

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154935 - 154935

Published: June 20, 2023

Language: Английский

Citations

35
Recent progress in plant-derived polysaccharides with prebiotic potential for intestinal health by targeting gut microbiota: a review DOI
Xiaozhen Wang, Xia Li, Luyao Zhang

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(33), P. 12242 - 12271

Published: Aug. 31, 2023

Natural products of plant origin are high interest and widely used, especially in the food industry, due to their low toxicity wide range bioactive properties. Compared other components, safety polysaccharides has been generally recognized. As dietary fibers, plant-derived mostly degraded intestine by polysaccharide-degrading enzymes secreted gut microbiota, have potential prebiotic activity both non-disease disease states, which should not be overlooked, terms involvement treatment intestinal diseases promotion health. This review elucidates regulatory effects on microbiota summarizes mechanisms involved targeting for diseases. Further, structure-activity relationships between different structural types occurrence further explored. Finally, practical applications production packaging summarized discussed, providing important references expanding application industry or developing functional supplements.

Language: Английский

Citations

34
Volatile Markers for Cancer in Exhaled Breath—Could They Be the Signature of the Gut Microbiota? DOI Creative Commons
Manohar Prasad Bhandari, Inese Poļaka, Reinis Vangravs

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(8), P. 3488 - 3488

Published: April 15, 2023

It has been shown that the gut microbiota plays a central role in human health and disease. A wide range of volatile metabolites present exhaled breath have linked with proposed as non-invasive marker for monitoring pathological conditions. The aim this study was to examine possible correlation between organic compounds (VOCs) fecal microbiome by multivariate statistical analysis gastric cancer patients (n = 16) healthy controls 33). Shotgun metagenomic sequencing used characterize microbiota. Breath-VOC profiles same participants were identified an untargeted gas chromatography-mass spectrometry (GC-MS) technique. approach involving canonical (CCA) sparse principal component significant relationship VOCs This relation found differ controls. In 16 cases, 14 distinct from belonging hydrocarbons, alcohols, aromatics, ketones, ethers, organosulfur highly correlated 33 bacterial taxa (correlation 0.891, p-value 0.045), whereas controls, 7 aldehydes, esters, phenols, benzamide derivatives 17 0.871, 0.0007). suggested effective identifying functional effects microbiome, thus helping understand cancer-related changes improving survival life expectancy patients.

Language: Английский

Citations

22
The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases DOI Creative Commons
Lara Pires, Ana M. Gonzaléz‐Paramás, Sandrina A. Heleno

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(5), P. 392 - 392

Published: April 25, 2024

Chronic diseases (CD) may result from a combination of genetic factors, lifestyle and social behaviours, healthcare system influences, community environmental determinants health. These risk factors frequently coexist interact with one another. Ongoing research focus on personalized interventions are pivotal strategies for preventing managing chronic disease outcomes. A wealth literature suggests the potential involvement gut microbiota in influencing host metabolism, thereby impacting various associated diseases. Dysbiosis, perturbation composition activity microbiota, is crucial etiopathogenesis multiple CD. Recent studies indicate that specific microorganism-derived metabolites, including trimethylamine N-oxide, lipopolysaccharide uremic toxins, contribute to subclinical inflammatory processes implicated Various diet, lifestyle, medications, can alter taxonomic species or abundance microbiota. Researchers currently dedicating efforts understanding how natural progression microbiome development humans affects health Simultaneously, there enhancing microbiome–host molecular interactions. endeavours ultimately aim devise practical approaches rehabilitating dysregulated human microbial ecosystems, intending restore prevent This review investigates contributes CD explains ways modulate it conditions.

Language: Английский

Citations

8
Exploiting the interactions between plant proteins and gut microbiota to promote intestinal health DOI Creative Commons
Jie Jia, Andrea Dell’Olio, David Izquierdo-Sandoval

et al.

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104749 - 104749

Published: Oct. 1, 2024

Language: Английский

Citations

8
Untargeted metabolomic profiling of serum from client-owned cats with early and late-stage chronic kidney disease DOI Creative Commons
Nora Jean Nealon, Stacie Summers, Jessica M. Quimby

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 27, 2024

Abstract Evaluation of the metabolome could discover novel biomarkers disease. To date, characterization serum client-owned cats with chronic kidney disease (CKD), which shares numerous pathophysiological similarities to human CKD, has not been reported. CKD is a leading cause feline morbidity and mortality, can be lessened early detection appropriate treatment. Consequently, there an urgent need for early-CKD biomarkers. The goal this cross-sectional, prospective study was characterize global, non-targeted versus late-stage compared healthy cats. Analysis revealed distinct separation between cats, early-stage CKD. Differentially abundant lipid amino acid metabolites were primary contributors these differences included central metabolism fatty acids, essential acids uremic toxins. Correlation multiple clinical metadata important monitoring patient treatment (e.g. creatinine, muscle condition score) further illustrates relevance exploring metabolite classes their capacity serve as in both populations.

Language: Английский

Citations

7
Oral Cardiac Drug–Gut Microbiota Interaction in Chronic Heart Failure Patients: An Emerging Association DOI Open Access
Ioannis Paraskevaidis, Αlexandros Briasoulis, Elias Tsougos

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1716 - 1716

Published: Jan. 31, 2024

Regardless of the currently proposed best medical treatment for heart failure patients, morbidity and mortality rates remain high. This is due to several reasons, including interaction between oral cardiac drug administration gut microbiota. The relation drugs (especially antibiotics) microbiota well established, but it also known that more than 24% non-antibiotic affect microbiota, altering microbe's environment its metabolic products. Heart lies mainly in blockage neuro-humoral hyper-activation. There debate as whether heart-failure-specific can totally block this hyper-activation, or so-called intestinal dysbiosis commonly observed group patients their action. Although there are reports indicating a strong drug-gut interplay, little about chronic failure. In review, we review contemporary data on topic infancy. We aim produce scientific thoughts questions provide reasoning further clinical investigation.

Language: Английский

Citations

6
Recent trends in nanocellulose: Metabolism-related, gastrointestinal effects, and applications in probiotic delivery DOI
Ao Liu,

Hailian Wu,

Zishu Dong

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122442 - 122442

Published: July 1, 2024

Language: Английский

Citations

6
Reno-protective Effects of Empagliflozin in High Fat Diet Induced Obesity-Related Glomerulopathy by Regulation of Gut-Kidney Axis DOI
Lei Lei, Ting Zhu,

Tian-Jiao Cui

et al.

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 327(4), P. C994 - C1011

Published: Aug. 26, 2024

The increasing prevalence of obesity-related glomerulopathy (ORG) poses a significant threat to public health. Sodium-glucose cotransporter-2 (SGLT2) inhibitors effectively reduce body weight and total fat mass in individuals with obesity halt the progression ORG. However, underlying mechanisms their reno-protective effects ORG remain unclear. We established high-fat diet-induced model using C57BL/6J mice, which were divided into three groups: normal chow diet (NCD group), (HFD) mice treated placebo (ORG HFD empagliflozin (EMPA group). conducted 16S ribosomal RNA gene sequencing feces analyzed metabolites from kidney, feces, liver, serum samples. showed increased urinary albumin creatinine ratio, cholesterol, triglyceride levels, glomerular diameter compared NCD (all P < 0.05). EMPA treatment significantly alleviated these parameters Multitissue metabolomics analysis revealed lipid metabolic reprogramming was altered by treatment. MetOrigin close association between EMPA-related pathways gut microbiota alterations, characterized reduced abundances Firmicutes Desulfovibrio abundance Akkermansia homeostasis especially metabolism, disrupted closely associated contributing improved kidney function morphology regulating metabolism through gut-kidney axis, highlighting novel therapeutic approach for NEW & NOTEWORTHY Our study uncovered that (EMPA) potentially protects renal axis. EMPA's are glycerophospholipid pantothenate/CoA synthesis pathways. modulation appears be pivotal suppressing glycerol 3-phosphate CoA synthesis. insights microbiota-host interactions offer

Language: Английский

Citations

6
An Overview of Chronic Kidney Disease Pathophysiology: The Impact of Gut Dysbiosis and Oral Disease DOI Creative Commons
Serena Altamura, Davide Pietropaoli, Francesca Lombardi

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3033 - 3033

Published: Nov. 12, 2023

Chronic kidney disease (CKD) is a severe condition and significant public health issue worldwide, carrying the burden of an increased risk cardiovascular events mortality. The traditional factors that promote onset progression CKD are cardiometabolic like hypertension diabetes, but non-traditional contributors escalating. Moreover, gut dysbiosis, inflammation, impaired immune response emerging as crucial mechanisms in pathology. microbiome exert reciprocal influence commonly referred to "the gut-kidney axis" through induction metabolic, immunological, endocrine alterations. Periodontal diseases strictly involved axis for their impact on microbiota composition metabolic immunological alterations occurring reciprocally affecting both conditions. This review aims provide overview dynamic biological interconnections between oral status, gut, renal pathophysiology, spotlighting oral-gut-kidney raising whether periodontal can be modifiers CKD. By doing so, we try offer new insights into therapeutic strategies may enhance clinical trajectory patients, ultimately advancing our quest improved patient outcomes well-being.

Language: Английский

Citations

16