Toxins,
Journal Year:
2023,
Volume and Issue:
15(11), P. 639 - 639
Published: Nov. 1, 2023
Of
the
wide
variety
of
toxic
compounds
produced
by
cyanobacteria,
neurotoxic
amino
acid
β-N-methylamino-l-alanine
(BMAA)
has
attracted
attention
as
a
result
its
association
with
chronic
human
neurodegenerative
diseases
such
ALS
and
Alzheimer’s.
Consequently,
specific
detection
methods
are
required
to
assess
presence
BMAA
isomers
in
environmental
clinical
materials,
including
cyanobacteria
mollusks.
Although
separation
β-amino-N-methylalanine
(BAMA),
N-(2-aminoethyl)glycine
(AEG)
2,4-diaminobutyric
(DAB)
from
been
demonstrated
during
routine
analysis,
further
compounding
factor
is
potential
enantiomers
for
some
these
isomers.
Current
analytical
mostly
do
not
discriminate
between
enantiomers,
chiral
configuration
still
largely
unexplored.
To
understand
occurrence
D-BMAA
UPLC-MS/MS
method
was
developed
separate
determine
enantiomeric
endogenous
free
marine
Lyngbya
mat
two
mussel
reference
materials.
After
extraction,
purification
derivatization
N-(4-nitrophenoxycarbonyl)-l-phenylalanine
2-methoxyethyl
ester
((S)-NIFE),
both
L-
were
identified
acids
cyanobacterial
whereas
only
L-BMAA
tissues.
The
finding
biological
materials
raises
questions
concerning
source
role
neurological
disease.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9194 - 9194
Published: Aug. 24, 2024
Marine
algal
toxins
have
garnered
significant
attention
in
the
research
community
for
their
unique
biochemical
properties
and
potential
medical
applications.
These
bioactive
compounds,
produced
by
microalgae,
pose
risks
due
to
high
toxicity,
yet
offer
promising
therapeutic
benefits.
Despite
extensive
identifying
over
300
marine
toxins,
including
azaspiracids,
brevetoxins,
cyclic
imines,
yessotoxins,
gaps
remain
understanding
of
pharmacological
potential.
In
this
paper,
we
critically
review
classification,
components,
toxicology,
activities,
mechanisms
these
with
a
particular
focus
on
clinical
Our
motivation
stems
from
increasing
interest
as
candidates
drug
development,
driven
specificity
affinity
various
biological
receptors.
We
aim
bridge
gap
between
toxicological
application,
offering
insights
into
advantages
limitations
compounds
comparison
other
substances.
This
not
only
enhances
toxins'
complexity
diversity,
but
also
highlights
application
medicine
bioscience,
providing
foundation
future
development
field.
Toxins,
Journal Year:
2023,
Volume and Issue:
15(11), P. 639 - 639
Published: Nov. 1, 2023
Of
the
wide
variety
of
toxic
compounds
produced
by
cyanobacteria,
neurotoxic
amino
acid
β-N-methylamino-l-alanine
(BMAA)
has
attracted
attention
as
a
result
its
association
with
chronic
human
neurodegenerative
diseases
such
ALS
and
Alzheimer’s.
Consequently,
specific
detection
methods
are
required
to
assess
presence
BMAA
isomers
in
environmental
clinical
materials,
including
cyanobacteria
mollusks.
Although
separation
β-amino-N-methylalanine
(BAMA),
N-(2-aminoethyl)glycine
(AEG)
2,4-diaminobutyric
(DAB)
from
been
demonstrated
during
routine
analysis,
further
compounding
factor
is
potential
enantiomers
for
some
these
isomers.
Current
analytical
mostly
do
not
discriminate
between
enantiomers,
chiral
configuration
still
largely
unexplored.
To
understand
occurrence
D-BMAA
UPLC-MS/MS
method
was
developed
separate
determine
enantiomeric
endogenous
free
marine
Lyngbya
mat
two
mussel
reference
materials.
After
extraction,
purification
derivatization
N-(4-nitrophenoxycarbonyl)-l-phenylalanine
2-methoxyethyl
ester
((S)-NIFE),
both
L-
were
identified
acids
cyanobacterial
whereas
only
L-BMAA
tissues.
The
finding
biological
materials
raises
questions
concerning
source
role
neurological
disease.
