Fumonisin Distorts the Cellular Membrane Lipid Profile: A Mechanistic Insight DOI Creative Commons
Omeralfaroug Ali,

András Szabó

Toxicology, Journal Year: 2024, Volume and Issue: 506, P. 153860 - 153860

Published: June 12, 2024

Monitoring modifications in membrane lipids association with external stimuli/agents, including fumonisins (FUMs), is a widely employed approach to assess cellular metabolic response/status. FUMs are prevalent fusariotoxins worldwide that have diverse structures varying toxicity across species; nevertheless, they can induce disturbances and disease, cancer. The capacity of disrupt lipids, demonstrated numerous species organs/tissues, ascribed multitude factors/events, which range from direct indirect effects. Certain events well established, whereas the potential consequences others remain speculative. most notable effect their resemblance sphingoid bases, impacts synthesis ceramides leading changes lipids' composition not limited sphingolipids' membranes. next plausible scenario involves induction oxidative stress, considered an indirect/secondary FUMs. Additional modes action include enzyme activities nuclear signals related lipid metabolism, although these likely yet fully comprehended. This review provides in-depth insight into current state mechanistic actions modifying focus on long-chain fatty acids. paper also presents detailed description reported by

Language: Английский

New insights into the mechanism of T-2 toxin cytotoxicity: stress granules inhibit the mTORC2/AKT signaling pathway DOI

Tianqing Jiang,

Liang Deng,

Ruqin Lin

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106806 - 106806

Published: May 1, 2025

Language: Английский

Citations

0
Exposure to a Combination of Fusarium Mycotoxins Leads to Lipid Peroxidation and Influences Antioxidant Defenses, Fatty Acid Composition of Phospholipids, and Renal Histology in Laying Hens DOI Creative Commons
Szabina Kulcsár,

Janka Turbók,

György Kövér

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(5), P. 226 - 226

Published: May 13, 2024

The effects of combined short-term (3 days) exposure to Fusarium mycotoxins at both the EU recommended limit (T-2/HT-2 toxin: 0.25 mg/kg; DON/3-AcDON/15-AcDON: 5 FB1: 20 mg/kg) and twice dose 0.5 mg/kg, 10 40 mg/kg feed) on kidneys laying hens were examined. Our study aimed investigate how these interacted with membrane lipid fatty acid (FA) composition peroxidation processes. It was observed that levels conjugated dienes trienes higher than control in low-mix group day 3, malondialdehyde concentration days 2 3. proportion phospholipid (PL) FAs showed saturated monounsaturated increased. Still, n3 n6 polyunsaturated decreased significantly high-mix group. Among FAs, level docosahexaenoic (C22:6 n3) among arachidonic (C20:4 n6) acids mainly results suggest induced hens, which resulted marked changes PL FA profile. Histological examination revealed time- dose-dependent increases as consequences mycotoxin exposure.

Language: Английский

Citations

3
CYP2E1 mediated deoxynivalenol-induced hepatocyte toxicity by regulating ferroptosis DOI
Qigui Mo,

Chenchen Song,

Yu Hua

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 508, P. 153923 - 153923

Published: Aug. 13, 2024

Language: Английский

Citations

3
Fumonisin Distorts the Cellular Membrane Lipid Profile: A Mechanistic Insight DOI Creative Commons
Omeralfaroug Ali,

András Szabó

Toxicology, Journal Year: 2024, Volume and Issue: 506, P. 153860 - 153860

Published: June 12, 2024

Monitoring modifications in membrane lipids association with external stimuli/agents, including fumonisins (FUMs), is a widely employed approach to assess cellular metabolic response/status. FUMs are prevalent fusariotoxins worldwide that have diverse structures varying toxicity across species; nevertheless, they can induce disturbances and disease, cancer. The capacity of disrupt lipids, demonstrated numerous species organs/tissues, ascribed multitude factors/events, which range from direct indirect effects. Certain events well established, whereas the potential consequences others remain speculative. most notable effect their resemblance sphingoid bases, impacts synthesis ceramides leading changes lipids' composition not limited sphingolipids' membranes. next plausible scenario involves induction oxidative stress, considered an indirect/secondary FUMs. Additional modes action include enzyme activities nuclear signals related lipid metabolism, although these likely yet fully comprehended. This review provides in-depth insight into current state mechanistic actions modifying focus on long-chain fatty acids. paper also presents detailed description reported by

Language: Английский

Citations

2