Promising Natural Remedies for Alzheimer’s Disease Therapy

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 922 - 922

Published: Feb. 17, 2025

This study examines the intricacies of Alzheimer's disease (AD), its origins, and potential advantages various herbal extracts natural compounds for enhancing memory cognitive performance. Future studies into AD treatments are encouraged by review's demonstration effectiveness phytoconstituents that were extracted from a number plants. In addition to having many beneficial effects, such as improved cholinergic function, medicines also much less harmful, more readily available, easier use than other treatments. They pass without difficulty through blood-brain barrier (BBB). focused on substances their effects using academic databases identify peer-reviewed published between 2015 2024. According literature review, 66 isolated 21 distinct plants have shown efficacy, which could be encouraging future research therapies. Since most clinical trials produce contradictory results, suggests larger-scale with longer treatment durations necessary validate or refute therapeutic efficacy

Language: Английский

Proteomic Insights into the Antimicrobial Mechanism of Chelerythrine Against Methicillin-Resistant Staphylococcus aureus

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(3)

Published: March 1, 2025

Background Methicillin-resistant Staphylococcus aureus (MRSA) is a major global health threat, causing infections that are difficult to treat due resistance standard antibiotics. The high mortality rates and limited treatment options for MRSA underscore the urgent need novel therapeutic agents. Chelerythrine, natural alkaloid, has shown potent antimicrobial activity against MRSA. However, molecular mechanisms underlying its antibacterial effects, particularly impact on bacterial proteomes, remain poorly understood. This study investigates chelerythrine's efficacy time-dependent effects proteome uncover key metabolic pathways targeted by this compound. Methods minimum inhibitory concentration (MIC) of chelerythrine was determined using microdilution method. Proteomic changes were analyzed label-free quantitative mass spectrometry at 30, 60, 120 min post-exposure. Fuzzy C-means (FCM) clustering employed identify protein expression patterns. Results Chelerythrine exhibited with MIC 19.54 mg/L MRSA, dose-dependent growth inhibition. analysis identified 1037 proteins, 447, 340, 265 proteins showing significant min, respectively. FCM revealed three clusters, Cluster 3 (36 proteins) specific downregulation under treatment. Gene Ontology (GO) KEGG analyses indicated enrichment in pathways, glycolysis, tricarboxylic acid cycle, arginine catabolism, highlighting effect energy production. Conclusion disrupts those involved production amino metabolism, suggesting potential as an agent.

Language: Английский

Anti-Candida albicans effect and mechanism of Pachysandra axillaris Franch.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119284 - 119284

Published: Dec. 25, 2024

Language: Английский