Perspectives on the Use of Echinocandins in the Neonatal Intensive Care Unit DOI Creative Commons
Niki Dermitzaki, Foteini Balomenou, Dimitra Gialamprinou

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1209 - 1209

Published: Dec. 12, 2024

The neonatal intensive care unit (NICU) population, especially low birth weight and critically ill neonates, is at risk of invasive Candida infections, which are associated with high mortality rates unfavorable long-term outcomes. timely initiation an appropriate antifungal treatment has been demonstrated to enhance the prognosis. Factors that should be considered in choice agent include causative strain, presence location deep tissue infection, any previous use prophylaxis, implanted devices. Amphotericin B fluconazole, first-line drugs for candidiasis, not always suitable due several limitations terms efficacy adverse effects. Therefore, alternative antifungals have studied used neonates when conventional ineffective or contraindicated. This narrative review aims provide overview current literature regarding echinocandins population. three echinocandins, micafungin, caspofungin, anidulafungin, share characteristics make them useful including activity against a wide range strains biofilms favorable safety profile.

Language: Английский

Diagnosis and Management of Neonatal Bacterial Sepsis: Current Challenges and Future Perspectives DOI Creative Commons
Domenico Umberto De Rose,

Maria Paola Ronchetti,

Ludovica Martini

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(9), P. 199 - 199

Published: Aug. 28, 2024

Sepsis remains the second cause of death among neonates after pathological consequences extreme prematurity. In this review we summarized knowledge about pathogens causing early-onset sepsis (EOS) and late-onset (LOS), role perinatal risk factors in determining EOS risk, tools used to reduce unnecessary antibiotics. New molecular assays could improve accuracy standard blood cultures, providing opportunity for a quick sensitive tool. Different criteria biomarkers are available date, but further research is needed guide use antibiotics according these tools. Beyond historical antibiotic regimens LOS episodes, should be based on local flora promptly modulated if specific identified. The possibility an lock therapy central venous catheters investigated. near future, artificial intelligence help us personalize treatments increasing trend multidrug-resistant bacteria.

Language: Английский

Citations

7
Frequency and types of antibiotic usage in a referral neonatal intensive care unit, based on the world health organization classification (AwaRe) DOI Creative Commons

Farzaneh Hematian,

Seyyed Mohammad Hassan Aletayeb,

Masoud Dehdashtian

et al.

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 24, 2025

Excessive prescription of antibiotics in infants increases the risk short-term and lifelong morbidity mortality. Nonetheless, use neonatal intensive care units (NICUs) is significantly high. This primarily because neonatologists are concerned about fragile immune systems newborns, their vulnerability to serious infectious diseases, challenge accurately distinguishing between non-infectious conditions. A five-month cross-sectional prospective study was conducted southwestern Iran's largest unit. aimed evaluate dose duration antibiotic therapy identify prescribing pattern based on Access, Watch, Reserve (AWaRe) classification recommended by World Health Organization (WHO). Out 502 examined patient files, were prescribed for 483 neonates. The most common drug combinations ampicillin amikacin. mean number administration 2.14 drugs 7.78 days, respectively. 84.3% received ten days or less. course newborns 1.1, 83.1% from Access Group. rate high our study's department. Most neonates two one group.

Language: Английский

Citations

0
Elimination of Candida Sepsis and Reducing Several Morbidities in a Tertiary NICU in Greece After Changing Antibiotic, Ventilation, and Nutrition Protocols DOI Creative Commons
Niki Dermitzaki,

Natalia Atzemoglou,

Vasileios Giapros

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 159 - 159

Published: Feb. 5, 2025

Background/Objectives: In recent years, strategies for improving outcomes in preterm neonates have been implemented various aspects of neonatal care. This study aims to determine the prevalence, microbiology, and late-onset sepsis (LOS) incidence other morbidities very following implementation specific infection control, enteral feeding, ventilation strategies. Methods: retrospectively compared morbidity mortality with a 23–32 weeks gestational age over two periods, period A (2010–2014),and B (2018–2022). series changes were introduced between these including restrictive use antibiotics, aggressive wider non-invasive modalities. Results: total 310 included: 163 147 B. The mean duration antibiotic treatment was reduced from 4 ± 2 1 days 5 3 suspected early-onset LOS, respectively, 11.2 16 confirmed LOS periods. 24% 18%, while, multiple episodes, it 26% 11% periods B, respectively. Total parenteral nutrition (TPN) independent predictors both rate Candida infections declined 9.2% 0.7%. full achieved after median 7.5 10 (p = 0.001), resulting fewer TPN 0.008). Episodes feeding intolerance necrotizing enterocolitis I (NEC I) significantly < 0.001). Incidence intraventricular hemorrhage decreased. Conclusions: After changing antibiotic, ventilation, protocols, almost completely eliminated. episodes Early without adverse effects, food observed. elimination appears feasible when stewardship is conjunction interventions an NICU.

Language: Английский

Citations

0
Effective antimicrobial therapies needed for treatment of severe infections in African newborns DOI Creative Commons
Pui‐Ying Iroh Tam, Adrie Bekker, Julia Bielicki

et al.

Expert Review of Anti-infective Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Keywords: neonatal sepsisantimicrobial resistanceantimicrobial stewardshippharmacokineticsempiric regimens

Language: Английский

Citations

0
The accuracy of presepsin in diagnosing neonatal late-onset sepsis in critically ill neonates: a prospective study DOI
Cinzia Auriti, Domenico Umberto De Rose, Chiara Maddaloni

et al.

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Objectives The diagnostic accuracy of presepsin (P-SEP) in the newborn is still under evaluation. Methods In a multicenter study, we studied P-SEP as marker late-onset sepsis (LOS) critical newborns with underlying disorders, to define most accurate cut-off distinguish infected from uninfected patients. Results Sixty-nine/351 without infections at admission developed LOS. median value T0 (admission) was 518.0 ng/L (IQR 313.0–789.0), significant differences related diseases (p=0.52). neonates who LOS, increased onset infection (T1) (median: 816.0 ng/L) and after 24–48 h 901.0 compared their 560.0 (p<0.01 p=0.03, respectively). area ROC curve T1 0.71 (95 % CI 0.65–0.78) when all cases were included analysis 0.74 0.66–0.81) considering only confirmed sepsis. Approximately two-thirds patients correctly classified, setting 713 ng/L, negative predictive 89.0 %. Conclusions At has good diagnosing LOS critically ill newborns. newborns, not influenced by any pathology.

Language: Английский

Citations

0
Perspectives on the Use of Echinocandins in the Neonatal Intensive Care Unit DOI Creative Commons
Niki Dermitzaki, Foteini Balomenou, Dimitra Gialamprinou

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1209 - 1209

Published: Dec. 12, 2024

The neonatal intensive care unit (NICU) population, especially low birth weight and critically ill neonates, is at risk of invasive Candida infections, which are associated with high mortality rates unfavorable long-term outcomes. timely initiation an appropriate antifungal treatment has been demonstrated to enhance the prognosis. Factors that should be considered in choice agent include causative strain, presence location deep tissue infection, any previous use prophylaxis, implanted devices. Amphotericin B fluconazole, first-line drugs for candidiasis, not always suitable due several limitations terms efficacy adverse effects. Therefore, alternative antifungals have studied used neonates when conventional ineffective or contraindicated. This narrative review aims provide overview current literature regarding echinocandins population. three echinocandins, micafungin, caspofungin, anidulafungin, share characteristics make them useful including activity against a wide range strains biofilms favorable safety profile.

Language: Английский

Citations

0