Journal of Personalized Medicine,
Journal Year:
2021,
Volume and Issue:
11(11), P. 1201 - 1201
Published: Nov. 14, 2021
The
main
functions
of
adipose
tissue
are
thought
to
be
storage
and
mobilization
the
body’s
energy
reserves,
active
passive
thermoregulation,
participation
in
spatial
organization
internal
organs,
protection
body
from
lipotoxicity,
ectopic
lipid
deposition.
After
discovery
adipokines,
endocrine
function
was
added
above
list,
after
identification
crosstalk
between
adipocytes
immune
cells,
an
suggested.
Nonetheless,
it
turned
out
that
mechanisms
underlying
mutual
regulatory
relations
adipocytes,
preadipocytes,
their
microenvironment
complex
redundant
at
many
levels.
One
possible
way
elucidate
picture
adipose-tissue
regulation
is
determine
genetic
variants
correlating
with
obesity.
In
this
review,
we
examine
various
aspects
involvement
innate
responses
as
well
immune-response
genes
associated
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: March 16, 2022
Bovine
viral
diarrhea
virus
(BVDV)
is
the
causative
agent
of
bovine
diarrhea-mucosal
disease
(BVD-MD),
an
important
in
cattle
that
responsible
for
extensive
economic
losses
to
industry
worldwide.
Currently,
several
underlying
mechanisms
involved
replication,
pathogenesis,
and
evading
host
innate
immunity
BVDV
remain
be
elucidated,
particularly
during
early
stage
infection.
To
further
explore
BVDV-host
interactions,
transcriptomics
proteomics
profiles
BVDV-infected
MDBK
cells
were
sequenced
using
RNA-seq
iTRAQ
techniques,
respectively,
followed
by
integrative
analysis.
Compared
with
mock-infected
cells,
a
total
665
differentially
expressed
genes
(DEGs)
(391
down-regulated,
274
up-regulated)
725
proteins
(DEPs)
(461
264
identified.
Among
these,
DEGs
DEPs
verified
quantitative
RT-PCR
western
blot.
Following
gene
ontology
(GO)
annotation
KEGG
enrichment
analysis,
we
determined
these
significantly
enriched
multiple
cellular
signaling
pathways
including
NOD-like
receptor,
Toll-like
TNF,
NF-κB,
MAPK,
cAMP,
lysosome,
protein
processing
endoplasmic
reticulum,
lipid
metabolism,
apoptosis
pathways.
Significantly,
down-regulated
predominantly
associated
apoptosis-regulated
elements,
inflammatory
factors,
antiviral
elements
immunity,
thus,
indicating
could
inhibit
expression
facilitate
replication.
Meanwhile,
up-regulated
primarily
metabolism
autophagy
pathways,
utilize
metabolic
resources
cell
promote
However,
potential
interactions
required
experimental
validation.
Our
data
provide
overview
changes
providing
basis
exploring
interactions.
Computational and Structural Biotechnology Journal,
Journal Year:
2022,
Volume and Issue:
20, P. 4098 - 4109
Published: Jan. 1, 2022
We
aimed
at
investigating
host-virus
co-metabolism
during
SARS-CoV-2
infection.
Therefore,
we
extended
comprehensive
sex-specific,
whole-body
organ
resolved
models
of
human
metabolism
with
the
necessary
reactions
to
replicate
in
lung
as
well
selected
peripheral
organs.
Using
this
model,
obtained
following
key
results:
1.
The
predicted
maximal
possible
virus
shedding
rate
was
limited
by
isoleucine
availability.
2.
supported
initial
viral
load
depended
on
increase
CD4+
T-cells,
consistent
literature.
3.
During
infection,
changed
including
blood
metabolome,
which
agreed
metabolomic
studies
from
COVID-19
patients
and
healthy
controls.
4.
could
be
reduced
either
inhibition
guanylate
kinase
1
or
availability
amino
acids,
e.g.,
diet.
5.
variants
differed
their
rates,
inversely
linked
occurrences
sequences.
Taken
together,
study
presents
metabolic
crosstalk
between
host
emphasises
role
acid
particular
isoleucine.
As
such,
it
provides
an
example
how
computational
modelling
can
complement
more
canonical
approaches
gain
insight
into
identify
potential
therapeutic
strategies.
Viruses,
Journal Year:
2020,
Volume and Issue:
13(1), P. 46 - 46
Published: Dec. 30, 2020
P-selectin
glycoprotein
ligand-1
(PSGL-1)
is
a
cell
surface
that
binds
to
P-,
E-,
and
L-selectins
mediate
the
tethering
rolling
of
immune
cells
on
endothelium
for
migration
into
inflamed
tissues.
PSGL-1
has
been
identified
as
an
interferon-γ
(INF-γ)-regulated
factor
restricts
HIV-1
infectivity,
recently
found
possess
broad-spectrum
antiviral
activities.
Here
we
report
expression
in
virus-producing
impairs
incorporation
SARS-CoV
SARS-CoV-2
spike
(S)
glycoproteins
pseudovirions
blocks
pseudovirus
attachment
infection
target
cells.
These
findings
suggest
may
potentially
inhibit
coronavirus
replication
PSGL-1+
Journal of Personalized Medicine,
Journal Year:
2021,
Volume and Issue:
11(11), P. 1201 - 1201
Published: Nov. 14, 2021
The
main
functions
of
adipose
tissue
are
thought
to
be
storage
and
mobilization
the
body’s
energy
reserves,
active
passive
thermoregulation,
participation
in
spatial
organization
internal
organs,
protection
body
from
lipotoxicity,
ectopic
lipid
deposition.
After
discovery
adipokines,
endocrine
function
was
added
above
list,
after
identification
crosstalk
between
adipocytes
immune
cells,
an
suggested.
Nonetheless,
it
turned
out
that
mechanisms
underlying
mutual
regulatory
relations
adipocytes,
preadipocytes,
their
microenvironment
complex
redundant
at
many
levels.
One
possible
way
elucidate
picture
adipose-tissue
regulation
is
determine
genetic
variants
correlating
with
obesity.
In
this
review,
we
examine
various
aspects
involvement
innate
responses
as
well
immune-response
genes
associated
