Frontiers in Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: Aug. 14, 2023
The
wide
and
rapid
spread
of
the
COVID-19
pandemic
has
placed
an
unanticipated
burden
on
global
healthcare
sector.
This
necessitated
a
swift
response
from
international
community
to
reach
solution.
Efforts
were
made
in
parallel
develop
preventative
therapeutic
modalities.
Since
then,
drug
repurposing
blossomed
as
potentially
resolution
included
various
agents
with
anti-viral
anti-inflammatory
properties.
Corticosteroids,
being
potent
agents,
have
been
under
extensive
investigation.
Various
trials
recorded
beneficial
outcome
corticosteroids
decreasing
mortality
morbidity
COVID-19.
With
high
pace
escalating
events,
quality
study
design
clinical
are
varied.
Therefore,
this
aims
explore
role
disease.
It
inspects
molecular,
pharmacologic,
proof
behind
theory.
Sensors International,
Journal Year:
2022,
Volume and Issue:
3, P. 100171 - 100171
Published: Jan. 1, 2022
COVID-19
is
the
current
global
problem.
Billions
of
infected
cases
due
to
pandemic
cause
an
emergency
requirement
contain
pandemic.
A
basic
concept
manage
outbreak
early
diagnosis
and
prompt
treatment.
To
diagnose
COVID-19,
new
biosensors
become
interventions
that
are
hopeful
help
effective
diagnosis.
In
clinical
material
science,
issues
on
materials
detection
biosensor
very
interesting.
this
brief
review,
authors
summarize
discuss
sustainable
biosensor.
The
paper,
cellulose
graphene
-
based
specifically
focused
for
RNA
sensing,
antigenic
determination
immune
response
covered
in
short
article.
Life,
Journal Year:
2023,
Volume and Issue:
13(4), P. 937 - 937
Published: April 3, 2023
Inflammation
is
a
common
feature
of
many
respiratory
diseases,
such
as
pneumonia,
asthma,
pulmonary
fibrosis,
chronic
obstructive
disease
(COPD),
lung
cancer,
acute
injury,
and
COVID-19.
Flavonoids
have
demonstrated
their
anti-inflammatory
antioxidant
effects
by
influencing
inflammation
at
different
stages
majorly
impacting
several
diseases'
onset
development.
According
to
current
studies,
hesperidin,
one
the
most
abundant
polyphenols,
can
inhibit
transcription
factors
or
regulatory
enzymes
essential
for
controlling
inflammation-linked
mediators,
including
nuclear
factor-kappa
B
(NF-κB),
Inducible
nitric
oxide
synthase
(iNOS),
cyclooxygenase-2
(COX-2).
It
also
improved
cellular
defences
activating
ERK/Nrf2
signalling
pathway.
Therefore,
this
review
provides
latest
studies
on
effect
hesperidin
in
its
pharmacokinetic
profile,
innovative
drug
delivery
methods.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5352 - 5352
Published: March 10, 2023
More
than
three
years
ago,
the
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
caused
unforeseen
COVID-19
pandemic
with
millions
of
deaths.
In
meantime,
SARS-CoV-2
has
become
endemic
and
is
now
part
repertoire
viruses
causing
seasonal
severe
respiratory
infections.
Due
to
several
factors,
among
them
development
immunity
through
natural
infection,
vaccination
current
dominance
seemingly
less
pathogenic
strains
belonging
omicron
lineage,
situation
stabilized.
However,
challenges
remain
possible
new
occurrence
highly
variants
remains
a
threat.
Here
we
review
development,
features
importance
assays
measuring
neutralizing
antibodies
(NAbs).
particular
focus
on
in
vitro
infection
molecular
interaction
studying
binding
receptor
domain
(RBD)
its
cognate
cellular
ACE2.
These
assays,
but
not
measurement
SARS-CoV-2-specific
per
se,
can
inform
us
whether
produced
by
convalescent
or
vaccinated
subjects
may
protect
against
thus
have
potential
predict
risk
becoming
newly
infected.
This
information
extremely
important
given
fact
that
considerable
number
subjects,
vulnerable
persons,
respond
poorly
production
antibodies.
Furthermore,
these
allow
determine
evaluate
virus-neutralizing
capacity
induced
vaccines
administration
plasma-,
immunoglobulin
preparations,
monoclonal
antibodies,
ACE2
synthetic
compounds
be
used
for
therapy
assist
preclinical
evaluation
vaccines.
Both
types
relatively
quickly
adapted
emerging
virus
about
magnitude
cross-neutralization,
which
even
estimate
infected
appearing
variants.
Given
paramount
discuss
their
specific
features,
advantages
disadvantages,
technical
aspects
yet
fully
resolved
issues,
such
as
cut-off
levels
predicting
degree
vivo
protection.
Biology,
Journal Year:
2023,
Volume and Issue:
12(6), P. 843 - 843
Published: June 10, 2023
MMPs
are
enzymes
involved
in
SARS-CoV-2
pathogenesis.
Notably,
the
proteolytic
activation
of
can
occur
through
angiotensin
II,
immune
cells,
cytokines,
and
pro-oxidant
agents.
However,
comprehensive
information
regarding
impact
different
physiological
systems
with
disease
progression
is
not
fully
understood.
In
current
study,
we
review
recent
biological
advances
understanding
function
examine
time-course
changes
during
COVID-19.
addition,
explore
interplay
between
pre-existing
comorbidities,
severity,
MMPs.
The
reviewed
studies
showed
increases
MMP
classes
cerebrospinal
fluid,
lung,
myocardium,
peripheral
blood
serum,
plasma
patients
COVID-19
compared
to
non-infected
individuals.
Individuals
arthritis,
obesity,
diabetes,
hypertension,
autoimmune
diseases,
cancer
had
higher
levels
when
infected.
Furthermore,
this
up-regulation
may
be
associated
severity
hospitalization
period.
Clarifying
molecular
pathways
specific
mechanisms
that
mediate
activity
important
developing
optimized
interventions
improve
health
clinical
outcomes
better
knowledge
will
likely
provide
possible
pharmacological
non-pharmacological
interventions.
This
relevant
topic
might
add
new
concepts
implications
for
public
near
future.
Frontiers in Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: Aug. 14, 2023
The
wide
and
rapid
spread
of
the
COVID-19
pandemic
has
placed
an
unanticipated
burden
on
global
healthcare
sector.
This
necessitated
a
swift
response
from
international
community
to
reach
solution.
Efforts
were
made
in
parallel
develop
preventative
therapeutic
modalities.
Since
then,
drug
repurposing
blossomed
as
potentially
resolution
included
various
agents
with
anti-viral
anti-inflammatory
properties.
Corticosteroids,
being
potent
agents,
have
been
under
extensive
investigation.
Various
trials
recorded
beneficial
outcome
corticosteroids
decreasing
mortality
morbidity
COVID-19.
With
high
pace
escalating
events,
quality
study
design
clinical
are
varied.
Therefore,
this
aims
explore
role
disease.
It
inspects
molecular,
pharmacologic,
proof
behind
theory.
