The Antiviral Activity of Polyphenols DOI Creative Commons
Markus Burkard,

Alban Piotrowsky,

Christian Leischner

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have wide range employment, from food production to medical usages. Among beneficial applications polyphenols, their antiviral activity is gaining importance due increased prevalence drug‐resistant viruses such as herpes hepatitis B viruses. In present review, we provide an overview most promising or commonly used polyphenols mechanisms action focusing on effects enveloped clinical (double‐stranded linear partially double‐stranded circular DNA viruses, negative sense single‐stranded RNA with nonsegmented segmented genomes, positive viruses). The work emphasizes relevance in particular epigallocatechin‐3‐gallate resveratrol, alternative supportive antivirals. could interfere virtually all steps viral infection, adsorption release particles. against especially relevant given risk widespread outbreaks associated remarked recent COVID‐19 pandemic.

Language: Английский

Resveratrol Downmodulates Neutrophil Extracellular Trap (NET) Generation by Neutrophils in Patients with Severe COVID-19 DOI Creative Commons
Milena Mary de Souza Andrade, Vinícius Nunes Cordeiro Leal, Iara Grigoletto Fernandes

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(9), P. 1690 - 1690

Published: Aug. 29, 2022

The formation of microthrombi in lung autopsies indicates the involvement NETs immunopathogenesis severe COVID-19. Therefore, supplements inhibiting NET formation, association with drugs fewer adverse effects, should be a relevant strategy to attenuate disease. Resveratrol (RESV) is natural polyphenol an important antiviral and antioxidant role. To modulate neutrophils from patients infected SARS-CoV-2, we evaluated vitro effect RESV on formation. Herein, investigated 190 hospitalized moderate, severe, critical symptoms at Hospital das Clínicas, Brazil. We observed that neutrophilia COVID-19 infection composed activated profile able release spontaneously. Notably, decreased neutrophil-activated status free DNA, even under specific PMA stimulus. At present, there no evidence role infection. These findings suggest adjunctive therapies may help decrease inflammation viral or bacterial infection, improving patient outcomes.

Language: Английский

Citations

28
COVID-19 Therapeutic Potential of Natural Products DOI Open Access

Zhaoxuan Low,

Rafidah Lani, Vunjia Tiong

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9589 - 9589

Published: May 31, 2023

Despite the fact that coronavirus disease 2019 (COVID-19) treatment and management are now considerably regulated, severe acute respiratory syndrome 2 (SARS-CoV-2) is still one of leading causes death in 2022. The availability COVID-19 vaccines, FDA-approved antivirals, monoclonal antibodies low-income countries poses an issue to be addressed. Natural products, particularly traditional Chinese medicines (TCMs) medicinal plant extracts (or their active component), have challenged dominance drug repurposing synthetic compound libraries therapeutics. Their abundant resources excellent antiviral performance make natural products a relatively cheap readily available alternative for Here, we deliberately review anti-SARS-CoV-2 mechanisms potency (pharmacological profiles), application strategies intervention. In light advantages, this intended acknowledge potential as therapeutic candidates.

Language: Английский

Citations

19
Food Plant Secondary Metabolites Antiviral Activity and Their Possible Roles in SARS-CoV-2 Treatment: An Overview DOI Creative Commons
Deborah Giordano, Angelo Facchiano, Virginia Carbone

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2470 - 2470

Published: March 8, 2023

Natural products and plant extracts exhibit many biological activities, including that related to the defense mechanisms against parasites. Many studies have investigated functions of secondary metabolites reported evidence antiviral activities. The pandemic emergencies further increased interest in finding agents, efforts are oriented investigate possible activities human viruses their potential application treating or preventing SARS-CoV-2 infection. In this review, we performed a comprehensive analysis through silico vitro investigations, also vivo applications clinical trials, evaluate state knowledge on infection, with particular focus natural compounds present food plants. Although some seem be useful prevention as therapeutic management SARS-CoV-2, up now, no molecules can used treatment for COVID-19; however, more research is needed.

Language: Английский

Citations

17
Effect of resveratrol on herpesvirus encephalitis: Evidences for its mechanisms of action DOI
Ziwei Huang, Shan Li,

Lishan Zhong

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155476 - 155476

Published: Feb. 22, 2024

Language: Английский

Citations

6
Hydrogels for Local and Sustained Delivery of Bacteriophages to Treat Wound Infections DOI Creative Commons
Yung‐Hao Lin, Tejas Dharmaraj, Qingquan Chen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 10, 2024

Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant

Language: Английский

Citations

6
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity DOI Creative Commons
María Laura Sáiz, Marta L. DeDiego, Darío López-García

et al.

Clinical Epigenetics, Journal Year: 2021, Volume and Issue: 13(1)

Published: Oct. 11, 2021

SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors for entry into cells, serine protease TMPRSS2 S protein priming. Inhibition of activity or engagement with ACE2 NRP1 has been shown to be an effective strategy blocking infectivity viral spreading. Valproic acid (VPA; 2-propylpentanoic acid) is epigenetic drug approved clinical use. It produces potent antiviral anti-inflammatory effects through its function as a histone deacetylase (HDAC) inhibitor. Here, we propose VPA potential candidate tackle COVID-19, in which rapid spread replication, hyperinflammation are crucial elements.We used diverse cell lines (HK-2, Huh-7, HUVEC, Caco-2, BEAS-2B) analyze effect other HDAC inhibitors on expression ACE-2 NRP-1 their ability inhibit infectivity, production, inflammatory response. Treatment significantly reduced host proteins all mechanism mediated by inhibitory activity. The maintained after infection. Consequently, treatment cells before infection impairs production infectious viruses, but not that ACE2- NRP1-independent viruses (VSV HCoV-229E). Moreover, addition 1 h post-infection reduces dose-dependent manner without modifying genomic subgenomic messenger RNAs (gRNA sg mRNAs) levels N protein. cytokines (TNF-α IL-6) induced TNF-α diminished presence VPA.Our data showed blocks three essential processes determining severity COVID-19. downregulates NRP1, reducing SARS-CoV-2; it decreases yields, probably because affects virus budding virions stability; dampens triggered Thus, administering could considered safe COVID-19 patients until vaccines have rolled out across world.

Language: Английский

Citations

37
Potential beneficial effects of functional components of edible plants on COVID-19: Based on their anti-inflammatory and inhibitory effect on SARS-CoV-2 DOI Creative Commons

Yijing Pu,

Luyao Chen, Xu He

et al.

Food Innovation and Advances, Journal Year: 2023, Volume and Issue: 2(1), P. 44 - 59

Published: Jan. 1, 2023

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major public health threat. Edible plants are rich in bioactive components, with variety of functions, such as enhancing immunity, antiviral, anti-inflammatory and so on. Thus, the intake edible to boost body's resistance COVID-19 promising possibly affordable strategy. This review revisits effects functional components from (such polyphenols, polysaccharides, lectin, alkaloids, polyunsaturated fatty acids, terpenoids, saponins) on COVID-19. The inhibitory virus's entrance replication, immune enhancement discussed. And finally, we present prospects using plant ingredients vaccine adjuvants problems use for prevention Functional interacted structural proteins SARS-CoV-2 virus key enzymes recognition thereby inhibiting entry replication host. Meanwhile, these had could inhibit cytokine storms. Therefore, believe that can enhance human be applied development new therapies.

Language: Английский

Citations

15
Comparison of Vitamin D and Resveratrol Performances in COVID-19 DOI Open Access
Cristina Russo, Maria Stella Valle,

Luisa Malaguarnera

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2639 - 2639

Published: June 5, 2023

Over the last few years, we have experienced infection generated by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) often resulting in an exaggerated immune reaction and systemic inflammation. The preferred treatments against SARS-CoV-2 were those that mitigated immunological/inflammatory dysfunction. A variety of observational epidemiological studies reported vitamin D deficiency is a crucial factor many inflammatory diseases autoimmune diseases, as well susceptibility to contract infectious including acute infections. Similarly, resveratrol regulates immunity, modifying gene expression release proinflammatory cytokines cells. Therefore, it plays immunomodulatory role can be beneficial prevention development non-communicable associated with Since both also act immunomodulators pathologies, paid particular attention integrated treatment either or This article offers critical evaluation published clinical trials examined use adjuncts COVID-19 management. Furthermore, aimed compare anti-inflammatory antioxidant properties linked modulation system, along antiviral resveratrol.

Language: Английский

Citations

15
Structure-based computational screening of 470 natural quercetin derivatives for identification of SARS-CoV-2 Mpro inhibitor DOI Creative Commons
Abd. Kakhar Umar, James H. Zothantluanga, Jittima Amie Luckanagul

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e14915 - e14915

Published: March 14, 2023

Coronavirus disease 2019 (COVID-19) is a global pandemic infecting the respiratory system through notorious virus known as severe acute syndrome coronavirus 2 (SARS-CoV-2). Due to viral mutations and risk of drug resistance, it crucial identify new molecules having potential prophylactic or therapeutic effect against SARS-CoV-2 infection. In present study, we aimed inhibitor virtual screening compound library 470 quercetin derivatives by targeting main protease—Mpro (PDB ID: 6LU7). The study was carried out with computational techniques such molecular docking simulation studies (MDSS), dynamics (MD) simulations, mechanics generalized Born surface area (MMGBSA) techniques. Among natural derivatives, 382 (PubChem CID 65604) showed best binding affinity Mpro (−11.1 kcal/mol). Compound interacted LYS5, TYR126, GLN127, LYS137, ASP289, PHE291, ARG131, SER139, GLU288, GLU290 protein. Mpro-382 complex acceptable stability during 100 ns MD simulations. also an MM-GBSA free energy value -54.0 kcal/mol. affinity, stability, results for were better than those native ligand standard inhibitors ledipasvir cobicistat. conclusion our that has inhibit SARS-Cov-2 Mpro. However, further investigations in-vitro assays are recommended confirm its in-silico potency.

Language: Английский

Citations

14
Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study DOI Creative Commons

Kusuma Sai Davuluri,

Rajnandini Ghanghav,

Gunwant Ahire

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 4, 2024

Abstract Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of disease. In order to improve efficacy known drugs, combining drugs is promising approach. The current study was undertaken explore activity combination were reported anti-CHIKV activity. We explored effect different combinations six effective (2-fluoroadenine, emetine, lomibuvir, enalaprilat, metyrapone and resveratrol) at their non-toxic concentrations against CHIKV under post conditions in Vero cells. Focus-forming unit assay, real time RT-PCR, immunofluorescence western blot used determine titre. results revealed 2-fluoroadenine with either or emetine enalaprilat exerted inhibitory post-infection conditions. these additive nature compared individual drugs. suggest an anti-viral CHIKV. findings could serve as outline development innovative therapeutic approach future treat CHIKV-infected patients.

Language: Английский

Citations

5