Classification and Applications of Bio‐nanomaterials

Published: Dec. 13, 2024

Language: Английский

---

Can bacterial lysates be useful in prevention of viral respiratory infections in childhood? The results of experimental OM-85 studies

Frontiers in Pediatrics, Journal Year: 2022, Volume and Issue: 10

Published: Nov. 21, 2022

Respiratory tract infections (RTI) are mainly viral in origin and among the leading cause of childhood morbidity globally. Associated wheezing illness asthma still a clear unmet medical need. Despite continuous progress understanding processes involved their pathogenesis, preventive measures treatments failed to demonstrate any significant disease-modifying effect. However, last decades it was understood that early-life exposure microbes, may reduce risk infectious allergic disorders, increasing immune response efficacy. These results suggested treatment with bacterial lysates (BLs) acting on gut microbiota, could promote heterologous immunomodulation useful prevention recurrent RTIs inception persistence. This hypothesis has been supported by clinical experimental studies showing reduction RTI frequency severity after oral BL prophylaxis elucidating mechanisms. OM-85 is product whose anti-viral effects have most extensively studied vitro , animal, human cell translational animal infection/disease models. The latter studies, describing potential training-based activities such BL, protection against respiratory viruses, will be reported. In rhinovirus, influenza virus, syncytial virus severe acute coronavirus-2 effective modulating structure functions large numbers airways epithelial cells, when administered both orally intranasally.

Language: Английский

---

Emerging insights into the structure-activity relationship of water-soluble polysaccharides in antiviral therapy

European Journal of Medicinal Chemistry Reports, Journal Year: 2023, Volume and Issue: 10, P. 100122 - 100122

Published: Dec. 3, 2023

This review provides an overview of recent advancements in understanding the antiviral activities and mechanism action water-soluble polysaccharides (WSPs). Water-soluble are complex carbohydrate molecules derived from various natural sources, including plants, microorganisms, fungi. Their unique structural characteristics make them intriguing candidates for therapeutics. However, this review, we highlight emerging insights into multifaceted properties polysaccharides. These substances have exhibited ability to hinder activity viruses, encompassing both enveloped non-enveloped types. mechanisms encompass interference with viral attachment entry, inhibition replication, modulation host immune response, even direct virucidal effects. Furthermore, delve features that underpin their potential. Factors such as molecular weight, branching patterns, sulfation, acetylation play pivotal roles activity. Additionally, explore importance polysaccharide conformation, size, shape, solubility, charge density, stereochemistry influencing interactions particles cell receptors. Moreover, growing significance promising agents emphasizes need further research harness full therapeutic potential fight against diseases.

Language: Английский

---

Exploring promising electron-shuttling characteristics of Perilla frutescens and potential anti-viral activity via bioenergy generation in microbial fuel cells

Sustainable Chemistry and Pharmacy, Journal Year: 2023, Volume and Issue: 34, P. 101141 - 101141

Published: June 16, 2023

Language: Английский

---

Unlocking the potential of Garcinia atroviridis fruit polysaccharides: A synergistic approach for obesity and hypertension management

Food Bioscience, Journal Year: 2023, Volume and Issue: 57, P. 103553 - 103553

Published: Dec. 31, 2023

Language: Английский

---