Predictability of COVID-19 Infections Based on Deep Learning and Historical Data

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(16), P. 8029 - 8029

Published: Aug. 11, 2022

The COVID-19 disease has spread worldwide since 2020, causing a high number of deaths as well infections, and impacting economic, social health systems. Understanding its dynamics may facilitate better understanding behavior, reducing the impact similar diseases in future. Classical modeling techniques have failed predicting behavior this disease, they been unable to capture hidden features data collected about disease. present research benefits from capacity modern computers new trends artificial intelligence (AI), specifically three deep learning (DL) neural networks: recurrent network (RNN), gated unit (GRU), long short-term memory (LSTM). We thus modelled daily infections four countries (Saudi Arabia, Egypt, Italy, India) that vary their climates, cultures, populations, results show simple-structure RNN algorithm is at DL promising potential can be used efficiently even case limited datasets.

Language: Английский

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DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1553 - 1553

Published: Jan. 13, 2023

The SARS-CoV-2 pandemic has demonstrated the need to create highly effective antivirals and vaccines against various RNA viruses, including SARS coronaviruses. This paper provides a short review of innovative strategies in development coronaviruses, with focus on antisense antivirals, oligonucleotide adjuvants vaccines, vaccines. Well-developed viral genomic databases new opportunities for using post-genomic platform. most coronaviruses are those able form memory cells both humoral cellular immunity. efficiently stop replication without side effects. Oligonucleotide can resist rapidly changing sequences conserved regions their genomes generate long-term immune response. Oligonucleotides have been used as excellent decades, increasing data show that oligonucleotides could serve antigens vaccine formulations, becoming prospective tool system tuning.

Language: Английский

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Occurrence and Phylogenetic Analysis of Avian Coronaviruses in Domestic Pigeons (Columba livia domestica) in Poland between 2016 and 2020

Pathogens, Journal Year: 2022, Volume and Issue: 11(6), P. 646 - 646

Published: June 3, 2022

While disease control in racing pigeons and the potential role of as vectors transmitting viruses to poultry are importance, there is still a paucity data concerning occurrence coronaviruses pigeons. In this study, 215 domestic were tested for presence coronaviral genetic material using nested PCR method, which revealed 57 positive samples (26.51%). The difference coronavirus prevalence between young adult (34.34% 19.83%, respectively) has been found statistically significant. contrast, no significant demonstrated symptomatic asymptomatic birds, leaving influence on pigeon health uncertain. Phylogenetic analysis RdRp gene fragment allowed us assign all obtained strains Gammacoronavirus genus Igacovirus subgenus. phylogenetic tree plotted ML method that those sequences formed group most similar from China, Finland, Poland, single strain common starling suggests wide geographical distribution virus its possible transmission various species.

Language: Английский

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Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8573 - 8573

Published: May 10, 2023

Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required contribute meaningful in public health. In this context, the network Spanish laboratories for coronavirus (RELECOV) was created with main goal promoting actions speed up detection, analyses, evaluation at a national level, partially structured financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024). A sequencing control assessment (QCA) developed evaluate network's technical capacity. QCA full panel results showed lower hit rate lineage assignment compared that obtained variants. Genomic comprising 48,578 viral genomes were studied evaluated monitor SARS-CoV-2. The 36% increase sharing sequences. addition, analysis lineage/sublineage-defining mutations track virus characteristic mutation profiles Delta Omicron Further, phylogenetic analyses strongly correlated different variant clusters, obtaining robust reference tree. RELECOV has made it possible improve enhance genomic Spain. It provided tools monitoring characterization make knowledge efficiently quickly,

Language: Английский

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Vaccination and Transmission Risk during the Outbreak of B.1.1.529 (Omicron)

Vaccines, Journal Year: 2022, Volume and Issue: 10(7), P. 1003 - 1003

Published: June 23, 2022

Since its first description in November 2021, the SARS-CoV-2 variant of concern Omicron (B.1.1.529) has emerged as dominant strain COVID-19 pandemic. To date, it remains unclear if boosted vaccination protects against transmission. Using data from largest German Public Health Department, Cologne, we analyzed breakthrough infections booster-vaccinated infected persons (IP; group (BVG); n = 202) and fully vaccinated, not SARS-COV2-positive patients (>3 month after receiving second dose; unboosted, vaccinated (FVG); to close contacts compared an age- sex-matched unvaccinated control (UCG; 202). On average, IPs had 0.42 ± 0.52 relation total number BVG vs. 0.57 0.44 FVG 0.56 0.43 UVG (p 0.054). In median test, pairwise comparison revealed a significant difference between both other groups; no was found group. Now, these findings must be verified larger samples, considering role subvariants status contact person. However, importance booster breaking possible chains infection immune escape is obvious.

Language: Английский

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