A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection

Molecular Therapy — Methods & Clinical Development, Journal Year: 2023, Volume and Issue: 31, P. 101110 - 101110

Published: Sept. 16, 2023

SARS-CoV-2, the etiological agent behind coronavirus disease 2019 (COVID-19) pandemic, has continued to mutate and create new variants with increased resistance against WHO-approved spike-based vaccines. With a significant portion of worldwide population still unvaccinated waning immunity newly emerging variants, there is pressing need develop novel vaccines that provide broader longer-lasting protection. To generate protective COVID-19, we developed our second-generation vaccinia virus-based COVID-19 vaccine, TOH-VAC-2, encoded modified versions spike (S) nucleocapsid (N) proteins as well unique poly-epitope antigen contains immunodominant T cell epitopes from seven different SARS-CoV-2 proteins. We show restimulates cells PBMCs individuals formerly infected SARS-CoV-2. In mice, TOH-VAC-2 vaccination produces high titers S- N-specific antibodies generates robust S, N, antigens. The generated also capable protecting mice heterologous challenge recombinant VSV viruses express same Altogether, these findings demonstrate effectiveness versatile vaccine platform an alternative or complementary approach current

Language: Английский

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COVID-19 vaccine triggered autoimmune hepatitis: case report

European Journal of Hospital Pharmacy, Journal Year: 2022, Volume and Issue: 30(5), P. e1.6 - e4

Published: Oct. 7, 2022

Autoimmune hepatitis (AIH) is a non-contagious, chronic, inflammatory autoimmune disease in which one's own immune system attacks healthy, normal hepatic cells. The exact cause of AIH unknown; however, the combination genetic, environmental (eg, drugs and natural infection) immunological factors may lead to AIH. also be potentiated with use vaccines: this case reports one such event following immunisation, along 1 year follow-up. A female patient her late 20s presented hospital yellowish discolouration eyes, urine stools. Her medical history revealed that she had been vaccinated first dose COVID-19 vaccine 10 days earlier. She asymptomatic infection 3 months ago chronic analgesic consumption for migraine. was diagnosed as having through extensive clinical laboratory workup. This an immediate enhancement hidden disorder triggered by vaccination. adverse immunisation has adequate temporal relationship vaccine. causality can categorised 'indeterminate' considered potential signal

Language: Английский

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Current Advances in Viral Nanoparticles for Biomedicine

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Viral nanoparticles (VNPs) have emerged as crucial tools in the field of biomedicine. Leveraging their biological and physicochemical properties, VNPs exhibit significant advantages prevention, diagnosis, treatment human diseases. Through techniques such chemical bioconjugation, infusion, genetic engineering, encapsulation, these been endowed with multifunctional capabilities, including display functional peptides or proteins, encapsulation therapeutic drugs inorganic particles, integration imaging agents, conjugation bioactive molecules. This review provides an in-depth analysis biomedicine, elucidating diverse types, distinctive features, production methods, complex design principles behind VNPs. It highlights recent innovative research various applications, covering roles imaging, drug delivery, therapeutics, gene vaccines, immunotherapy, tissue regeneration. Additionally, assessment safety biocompatibility discusses challenges future opportunities field, underscoring vast potential evolving nature VNP research.

Language: Английский

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Co-Infection Associated with SARS-CoV-2 and Their Management

Future Science OA, Journal Year: 2022, Volume and Issue: 8(9)

Published: Oct. 1, 2022

SARS-CoV-2 was discovered in Wuhan, China and quickly spread throughout the world. This deadly virus moved from person to person, resulting severe pneumonia, fever, chills hypoxia. Patients are still experiencing problems after recovering COVID-19. review covers COVID-19 associated issues following recovery COVID-19, as well multiorgan damage risk factors treatment techniques. Several unusual illnesses, including mucormycosis, white fungus infection, happy hypoxia other systemic abnormalities, have been reported recovered individuals. In children, multisystem inflammatory syndrome with (MIS-C) is identified. The reasons for this might include uncontrollable steroid usage, reduced immunity, diabetes mellitus inadequate care recovery.

Language: Английский

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An updated review on pathogenic coronaviruses (CoVs) amid the emergence of SARS-CoV-2 variants: A look into the repercussions and possible solutions

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(11), P. 1870 - 1883

Published: Sept. 9, 2023

SARS-CoV-2, responsible for COVID-19, shares 79% and 50% of its identity with SARS-CoV-1 MERS-CoV, respectively. It uses the same main cell attachment entry receptor as SARS-CoV-1, which is ACE-2 receptor. However, key residues in receptor-binding domain S-protein seem to give it a stronger affinity better ability hide from host immune system. Like cytokine storms critically ill COVID-19 patients cause ARDS, neurological pathology, multiorgan failure, increased death. Though many issues remain, global research effort lessons MERS-CoV are hopeful. The emergence novel SARS-CoV-2 variants subvariants raised serious concerns among scientific community amid other viral diseases like monkeypox Marburg virus, major healthcare settings worldwide. Hence, an updated review on comparative analysis various coronaviruses (CoVs) has been developed, highlights evolution CoVs their repercussions.

Language: Английский

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