Exploring the Contrasts and Similarities of Dengue and SARS-CoV-2 Infections During the COVID-19 Era DOI Open Access
Alexis García, Juan Bautista De Sanctis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11624 - 11624

Published: Oct. 29, 2024

Extensive research has been conducted on the SARS-CoV-2 virus in association with various infectious diseases to understand pathophysiology of infection and potential co-infections. In tropical countries, exposure local viruses may alter course coinfection. Notably, only a portion antibodies produced against proteins demonstrate neutralizing properties, immune response following natural tends be temporary. contrast, long-lasting IgG are common after dengue infections. cases where preexisting from an initial bind different serotype during subsequent infection, there is for antibody-dependent enhancement (ADE) formation complexes associated disease severity. Both infections can result immunodeficiency. Viral both interfere host's IFN-I signaling. Additionally, cytokine storm occur viral impairing proper response, autoantibodies wide array appear convalescence. Most reported typically short-lived. Vaccines affecting enhancing clearance. A comprehensive analysis pathogenicity revisited prevent severity, mortality.

Language: Английский

The biology and function of extracellular vesicles in immune response and immunity DOI
Raghu Kalluri

Immunity, Journal Year: 2024, Volume and Issue: 57(8), P. 1752 - 1768

Published: Aug. 1, 2024

Language: Английский

Citations

25
Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health DOI Creative Commons
Pedro Pablo Martínez-Rojas,

Verónica Monroy-Martínez,

Blanca H. Ruíz-Ordaz

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 4, 2025

Abstract Mosquito-borne flaviviruses represent a public health challenge due to the high-rate endemic infections, severe clinical outcomes, and potential risk of emerging global outbreaks. Flavivirus disease pathogenesis converges on cellular factors from vectors hosts, their interactions are still unclear. Exosomes microparticles extracellular vesicles released cells that mediate intercellular communication necessary for maintaining homeostasis; however, they have been shown be involved in establishment progression. This review focuses roles mosquito-borne flavivirus diseases: how contribute viral cycle completion, cell-to-cell transmission, responses such as inflammation, immune suppression, evasion, well use biomarkers or therapeutics (antiviral vaccines). We highlight current findings concerning functionality different models dengue virus, Zika yellow fever Japanese encephalitis West Nile virus infections diseases. The available evidence suggests diverse functions between constituting novel effectors understanding pathogenic mechanisms flaviviral

Language: Английский

Citations

1
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells DOI Creative Commons
Jae Kwan Lee, Ok Sarah Shin

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 14, 2023

Zika virus (ZIKV) remains a global public health threat with the potential risk of future outbreak. Since viral infections are known to exploit mitochondria-mediated cellular processes, we investigated effects ZIKV infection in trophoblast cells terms different mitochondrial quality control pathways that govern integrity and function. Here demonstrate (PRVABC59) JEG-3 manipulates dynamics, mitophagy, formation mitochondria-derived vesicles (MDVs). Specifically, nonstructural protein 4A (NS4A) translocates mitochondria, triggers fission suppresses associated antiviral (MAVS)-mediated type I interferon (IFN) response. Furthermore, proteomics profiling small extracellular (sEVs) revealed an enrichment proteins sEVs secreted by ZIKV-infected cells, suggesting MDV may also be another mechanism manipulated during placental infection. Altogether, our findings highlight mechanisms as host immune evasion utilized at placenta suppress response facilitate

Language: Английский

Citations

19
Exosome-Mediated Antigen Delivery: Unveiling Novel Strategies in Viral Infection Control and Vaccine Design DOI Creative Commons

Daed El Safadi,

Alexandre Mokhtari,

Morgane Krejbich

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(3), P. 280 - 280

Published: March 7, 2024

Exosomes are small subtypes of extracellular vesicles (EVs) naturally released by different types cells into their environment. Their physiological roles appear to be multiple, yet many aspects biological activities remain understood. These can transport and deliver a variety cargoes may serve as unconventional secretory vesicles. Thus, they play crucial role important vectors for intercellular communication the maintenance homeostasis. Exosome production content vary under several stresses or modifications in cell microenvironment, influencing cellular responses stimulating immunity. During infectious processes, exosomes described double-edged swords, displaying both beneficial detrimental effects. Owing tractability, analysis EVs from multiple biofluids has become booming tool monitoring various pathologies, cancerous origins. In this review, we present an overview exosome features discuss particular ambiguous functions contexts. We then focus on properties diagnostic therapeutic tools. regard, explore capacity vectorize immunogenic viral antigens function mounting adaptive immune responses. As provide interesting platforms antigen presentation, further review available data engineering, which enables peptides interest exposed at surface. light all these data, emerging promising avenues vaccine strategies.

Language: Английский

Citations

8
Viral Components Trafficking with(in) Extracellular Vesicles DOI Creative Commons

Félix Rey-Cadilhac,

Florian Rachenne,

Dorothée Missé

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(12), P. 2333 - 2333

Published: Nov. 28, 2023

The global public health burden exerted by viruses partially stems from viruses’ ability to subdue host cells into creating an environment that promotes their multiplication (i.e., pro-viral). It has been discovered alter cell physiology transferring viral material through extracellular vesicles (EVs), which serve as vehicles for intercellular communication. Here, we aim provide a conceptual framework of all possible EV-virus associations and resulting functions in infection output. First, describe the different materials potentially associated with EVs reporting can harbor entire virions, proteins nucleic acids. We also delineate mechanisms underlying internalization these components EVs. Second, potential fate EV-associated cargo detailing how EV circulate target naive once secreted. Finally, itemize pro-viral strategies Trojan horse strategy, alternative mode transmission, expansion cellular tropism, pre-emptive alteration immunity decoy. With this overview, stimulate research on interactions.

Language: Английский

Citations

11
A game of hide-and-seek: how extracellular vesicles evade the immune system DOI Creative Commons
Bartika Ghoshal, Siddharth Jhunjhunwala

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

0
A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway DOI Creative Commons

Hée J,

Dayna Cheng,

Yu‐Hong Chen

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Feb. 20, 2025

Abstract Background The largest dengue virus 2 (DENV2) outbreak occurred in Taiwan 2015, resulting many fatalities. We therefore aim to identify crucial genetic variations which determine the virulence of 2015 strains. Methods compared DENV2 sequences pre-2015 sequences. Reverse genetics (rg) viruses with substitutions were produced and viral growth kinetics investigated. treated A549 cells interferon (IFN) interferon-stimulated genes (ISGs) expression STAT1 phosphorylation rg infection plasmid transfection systems. IFN pro-inflammatory cytokines levels measured upon DENV using ELISA. Results rgNS1-K272R mutant showed faster replication IFN-I producing wildtype (WT) virus. revealed that NS1-K272R substitution contributed higher soluble NS1 secretion evade antiviral response by suppressing ISGs NS1-WT. Infection induced through activation canonical nuclear factor-kappa B (NF-κB) signaling pathway. Conclusions Our results amino acid affects ability immune evasion, may contribute since 1990s.

Language: Английский

Citations

0
Dengue Virus and Lipid Metabolism: Unraveling the Interplay for Future Therapeutic Approaches DOI Creative Commons
Ying Xie, Jiao Li,

Qiangming Sun

et al.

Emerging Microbes & Infections, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

In recent years, Dengue virus (DENV) has continued to pose significant health risks in tropical and subtropical areas worldwide, raising alerts worldwide. It can cause hyperviremia humans even lead fatal clinical diseases. The life cycle of DENV is intricately linked cellular lipids, the selectively utilizes relevant enzymes involved lipid metabolism modulate existing metabolic system host cells during entry, replication, assembly, other stages, thereby creating an environment conducive its complete replication cycle. At present, there a lack effective specific anti-DENV treatment measures. This review summarizes recently identified molecules related diseases that affect infection, explores dependence on provides potential targets for dengue fever (DF).

Language: Английский

Citations

0
Beyond Infection: The Role of Secreted Viral Proteins in Pathogenesis, Disease Severity and Diagnostic Applications DOI Creative Commons

Luis Herrera-Moro Huitron,

Víctor Javier Cruz-Holguín,

José Manuel Ulloa-Aguilar

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 624 - 624

Published: April 22, 2025

Secreted viral proteins are crucial in virus–host interactions, as they modify the host microenvironment to promote infection. These secreted could alter immune and inflammatory responses, allowing viruses evade defense mechanisms such cytotoxic T cell activation antibody neutralization. Some mimic molecules suppress antiviral making them valuable targets for antivirals diagnostics. Notable examples include BARF1 from Epstein–Barr virus, associated with gastric cancer; vIL-10 which regulates responses contributes autoimmune diseases; NS1 dengue vascular permeability early diagnosis; NSP4 rotavirus an enterotoxin, among others. The study of these improves our understanding pathogenesis helps develop innovative treatments infectious non-infectious diseases, taking advantage evolutionary adaptations viruses. This review explores their impact on infection cycle, disease progression, key processes, cycle regulation, apoptosis, signaling. Research deepens basic knowledge virology generates alternative methods detecting biomarkers creating more effective therapies, well implementing some emerging technologies, biosensors plasmon resonance, diagnosis diseases.

Language: Английский

Citations

0
Extracellular vesicles in arbovirus infections: from basic biology to potential clinical applications DOI Creative Commons
Natalia Tiberti, Concetta Castilletti, Federico Gobbi

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 28, 2025

Arthropod-borne viruses, or arboviruses, are currently considered a global health threat responsible for potentially severe human diseases. The increased population density, changes in land use and climate change some of the factors that contributing to spread these infections over last years. pathogenesis diseases mechanisms interaction with host, especially those leading development forms, yet be fully understood. In recent years extracellular vesicles (EVs) have emerged as important players inter-cellular host-pathogen arising lot interest also field vector-borne viruses. this context, EVs seem play dual role, by either promoting, thus facilitating, preventing infection. Many studies showing how viruses can hijack vesiculation machinery escape host immune response exploit sustain their replication propagation, even though shed cells essential promote antiviral responses. manuscript we reviewed current knowledge regarding association between paying particular attention possible role disease transmission dissemination, well potential novel tools clinical applications, spanning from biomarkers utility therapeutic options.

Language: Английский

Citations

0