Characterization of SARS-CoV-2 Variants in Military and Civilian Personnel of an Air Force Airport during Three Pandemic Waves in Italy
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(11), P. 2711 - 2711
Published: Nov. 5, 2023
We
investigated
SARS-CoV-2
variants
circulating,
from
November
2020
to
March
2022,
among
military
and
civilian
personnel
at
an
Air
Force
airport
in
Italy
order
classify
viral
isolates
a
potential
hotspot
for
virus
spread.
Positive
samples
were
subjected
Next-Generation
Sequencing
(NGS)
of
the
whole
genome
Sanger
sequencing
spike
coding
region.
Phylogenetic
analysis
classified
traced
their
evolutionary
relationships.
Clusters
identified
using
70%
cut-off.
methods
yielded
comparable
results
terms
variant
classification.
In
2021,
we
several
variants,
including
B.1.258
(4/67),
B.1.177
(9/67),
Alpha
(B.1.1.7,
9/67),
Gamma
(P.1.1,
4/67),
Delta
(4/67).
only
Omicron
its
sub-lineage
observed
(37/67).
screened
detect
naturally
occurring
resistance
genomic
regions,
target
new
therapies,
comparing
them
Wuhan
Hu-1
reference
strain.
Interestingly,
2/30
non-Omicron
carried
G15S
3CLpro
substitution
responsible
reduced
susceptibility
protease
inhibitors.
On
other
hand,
unusual
substitutions
A1803V,
D1809N,
A949T
on
PLpro,
D216N
3CLpro.
Finally,
P323L
RdRp
regions
was
not
associated
with
mutational
pattern
related
polymerase
inhibitor
resistance.
This
study
highlights
importance
continuous
surveillance
monitor
evolution
general
population,
as
well
restricted
communities.
Language: Английский
Zoonotic Paramyxoviruses: Evolution, Ecology, and Public Health Strategies in a Changing World
Viruses,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1688 - 1688
Published: Oct. 29, 2024
The
family
Language: Английский
The evaluation of SARS-CoV-2 mutations at the early stage of the pandemic in Istanbul population
Annals of Clinical Microbiology and Antimicrobials,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Oct. 10, 2024
Determination
of
SARS-CoV-2
variant
is
significant
to
prevent
the
spreads
COVID-19
disease.
Language: Английский