Development of long COVID as a consequence of the complex relationship between Epstein-Barr virus and our immune system DOI Creative Commons
Ana Banko

Medicinski podmladak, Journal Year: 2023, Volume and Issue: 74(4), P. 15 - 20

Published: Jan. 1, 2023

Introduction: The pathophysiological development of long COVID (LC) is still insufficiently known. However, post infection fatigue syndromes were seen before, among other pathogens including Epstein-Barr virus (EBV). Considering EBV reservoir in COVID-19 patients, this review aims to present current knowledge related role LC and with the potential diagnostic utility. infection: Following primary lytic epithelial oropharyngeal nasopharyngeal cells establishes a very complex mechanism lifelong survival B cells. Latent occasional viral reactivations constantly challenges host's immune response. In individuals imbalance COVID-19, it could drive long-term consequences. COVID-19: activity has been shown as most prevalent human herpesvirus population (41%). Correlation between lymphocytopenia-induced disability remove EBV, increases DNA viremia complications have also reported. COVID: positivity during acute SARS-CoV-2 predicted presence symptoms up 60 days after COVID-19. Association such brain fog, fatigue, arthralgia skin rashes described sequelae ME/CFS. Anti-EBV early antigen-diffuse (EA-D) IgG antibodies detectable two-thirds respondents experiencing LC. Increases anti-EBNA1 levels analyzed months following onset convalescent serve marker reactivation at time infection. Some authors managed show anti-EBV capsid antigen (VCA) IgM seropositivity half patients indicating either coinfection or reactivation. Conclusion: As multisystemic illness, without defined spectrum treatment options. Whereas alone together risk factors drives symptoms, further prospective studies involving different cohorts tissue reservoirs are necessary understand underlying biological mechanisms.

Language: Английский

Fibrinaloid Microclots and Atrial Fibrillation DOI Creative Commons
Douglas B. Kell, Gregory Y.H. Lip, Etheresia Pretorius

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 891 - 891

Published: April 17, 2024

Atrial fibrillation (AF) is a comorbidity of variety other chronic, inflammatory diseases for which fibrinaloid microclots are known accompaniment (and in some cases, cause, with mechanistic basis). Clots are, course, well-known consequence atrial fibrillation. We here ask the question whether seen plasma or serum may fact also be cause (or contributor to) development AF. consider ‘risk factors’ AF, and particular, exogenous stimuli such as infection air pollution by particulates, both to The external accompaniments bacterial (lipopolysaccharide lipoteichoic acids) viral (SARS-CoV-2 spike protein) infections stimulate when added vitro, microclots, amyloid proteins, can cytotoxic, inducing hypoxia/reperfusion means. Strokes thromboembolisms common consequences Consequently, taking systems approach, we review considerable evidence detail, leads us suggest that it likely well have an aetiological role This has significant therapeutic implications.

Language: Английский

Citations

5
Fibrinaloid Microclots and Atrial Fibrillation DOI Open Access
Douglas B. Kell, Gregory Y.H. Lip, Etheresia Pretorius

et al.

Published: Jan. 29, 2024

Atrial fibrillation (AF) is a comorbidity of variety other chronic, inflammatory diseases for which fibrinaloid microclots are known accompaniment (and in some cases cause, with mechanistic basis). Clots are, course, well-known consequence atrial fibrillation. We here ask the question as to whether seen plasma or serum may fact also be cause (or contributor to) development AF. consider ‘risk factors’ AF, and particular exogenous stimuli such infection air pollution by particulates, both The external accompaniments bacterial (lipopolysaccharide lipoteichoic acids) viral (SARS-CoV-2 spike protein) infections stimulate when added vitro, cytotoxic inducing hypoxia/reperfusion means. Strokes thromboembolisms common consequences Consequently, taking systems approach, we suggest that it likely well have an aetiological role This has significant therapeutic implications.

Language: Английский

Citations

4
Insights into the interplay between Epstein‐Barr virus (EBV) and multiple sclerosis (MS): A state‐of‐the‐art review and implications for vaccine development DOI Creative Commons

Mahtab Mohammadzamani,

Kimia Kazemzadeh, Swati Chand

et al.

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(2)

Published: Feb. 1, 2024

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). MS results from an inflammatory process leading to loss neural tissue and increased disability over time. The role Epstein Barr Virus (EBV), as one most common global viruses, in development has been subject several studies. However, many related questions are still unanswered. This study aimed review connection between EBV provide quick outline prevention using vaccination.

Language: Английский

Citations

4
N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant Mycobacterium abscessus DOI Creative Commons
Shuqi Yang, Ying Zhang, Jinchuan Xu

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 302 - 302

Published: March 21, 2025

(1) Background: The treatment of Mycobacterium abscessus (M. abscessus) infections resistant to clarithromycin (CLR) is highly challenging. Traditional non-tuberculous mycobacteria (NTM) chemotherapy may disturb the immune homeostasis host by increasing oxidative stress; therefore, host-directed immunotherapy an alternative option for caused M. abscessus. (2) Method: A clinical isolate CLR-resistant was screened, and then therapeutic effects N-acetylcysteine (NAC) against infection were evaluated in Tohoku Hospital Pediatrics-1 (THP-1) cells murine models. RNA sequencing Western blot used profile protective responses induced NAC. contribution candidate signaling pathways confirmed corresponding inhibitor agonist. (3) Results: NAC led a significant reduction bacterial loads both THP-1 models, which associated with enhanced antioxidant downregulation apoptosis signal-regulating kinase 1 (ASK1)–mitogen-activated protein ki-nase/extracellular signal-regulated 3/6 (MKK3/6)–p38 mitogen-activated (MAPK)-mediated inflammatory responses. p38 mimicked effect NAC, while agonist attenuated it, suggesting that pathway crucial NAC-mediated protection infection. (4) Conclusion: Our study suggests could be as therapy agent drug-resistant

Language: Английский

Citations

0
Early and active treatment with fingolimod for pediatric onset multiple sclerosis: the experience of an Italian pediatric center over the past 3 years. DOI
Carlotta Canavese, Marta Borgogno,

Gloria Gallo

et al.

Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Post COVID challenges in chronic neurological conditions: exploring perceived symptoms and the potential effect of individual physiotherapy DOI Creative Commons

Klára Novotná,

Kristýna Dandová,

Ivana Knapová

et al.

Kontakt, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

Citations

0
COVID-19 and multiple sclerosis: challenges and lessons for patient care DOI Creative Commons
Luca Prosperini, Georgina Arrambide, Elisabeth Gulowsen Celius

et al.

The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 44, P. 100979 - 100979

Published: Aug. 23, 2024

During the COVID-19 pandemic, people with multiple sclerosis (MS) and their healthcare providers have faced unique challenges related to interaction between SARS-CoV-2, underlying neurological disease use of disease-modifying treatments (DMTs). Key concerns arose, primarily possibility that SARS-CoV-2 infection could trigger initial demyelinating event or exacerbate activity. Another major concern was safety efficacy vaccines, especially for patients undergoing specific weaken antibody responses. In post-infection phase, identifying long COVID in MS has been complicated due large overlap sequelae symptoms. addition, disruptions health rehabilitation services made it difficult access care. This Series article explores current evidence on identifies posed by pandemic care MS, discusses significant adoption digital solutions, including telemedicine new technology-based approaches. Based lessons learned, recommendations future directions are offered managing rethinking systems improving outcomes post-COVID-19 era.

Language: Английский

Citations

3
The Influence of SARS-CoV-2 Infection on the Development of Selected Neurological Diseases DOI Open Access

Klaudia Kryńska,

Katarzyna Kuliś,

Wiktoria Mazurek

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8715 - 8715

Published: Aug. 9, 2024

In 2024, over 775 million cases of COVID-19 were recorded, including approximately 7 deaths, indicating its widespread and dangerous nature. The disease is caused by the SARS-CoV-2 virus, which can manifest a wide spectrum symptoms, from mild infection to respiratory failure even death. Neurological such as headaches, confusion, impaired consciousness, have also been reported in some patients. These observations suggest potential invade central nervous system induce neuroinflammation during infection. This review specifically explores relationship between selected neurological diseases multiple sclerosis (MS), ischemic stroke (IS), Alzheimer's (AD). It has observed that virus increases production cytokines whose action cause destruction myelin sheaths nerve cells. Subsequently, body may synthesize autoantibodies attack cells, resulting damage brain's anatomical elements, potentially contributing onset sclerosis. Additionally, exacerbates inflammation, worsening clinical condition individuals already suffering MS. Moreover, secretion pro-inflammatory lead an escalation blood clot formation, result thrombosis, obstructing flow brain precipitating stroke. AD characterized intense inflammation heightened oxidative stress, both are exacerbated demonstrates enhanced cell entry presence ACE2 receptor, elevated ApoE ε4 allele. Consequently, worsens progresses more rapidly, increasing mortality rate among above information underscores numerous connections diseases.

Language: Английский

Citations

2
Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity DOI
Yekbun Adıgüzel, Naim Mahroum, Sylviane Muller

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2023, Volume and Issue: 65(2), P. 206 - 230

Published: July 28, 2023

Language: Английский

Citations

4
Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond H. pylori and Epstein-Barr Virus DOI Open Access
Wing Sum Shin, Fuda Xie, Bonan Chen

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(20), P. 4993 - 4993

Published: Oct. 15, 2023

While previous research has primarily focused on the impact of H. pylori and Epstein-Barr virus (EBV), emerging evidence suggests that other microbial influences, including viral fungal infections, may also contribute to gastric cancer (GC) development. The intricate interactions between these microbes host’s immune response provide a more comprehensive understanding pathogenesis, diagnosis, treatment. review highlights roles established players such as EBV potential impacts gut bacteria, mainly Lactobacillus, Streptococcus, hepatitis B virus, C fungi Candida albicans. Advanced sequencing technologies offer unprecedented insights into complexities microbiome, from diversity diagnostic applications. Furthermore, for advanced GC diagnosis therapies through better microbiome.

Language: Английский

Citations

4