Prospective Investigation of Feline Leukemia Virus Infection in Stray Cats Subjected to a Trap–Neuter–Return Program in Switzerland

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 394 - 394

Published: March 2, 2024

Feline leukemia virus (FeLV) remains a serious concern in some countries despite advances diagnostics and vaccines. FeLV-infected cats often have reduced lifespans due to FeLV-associated diseases. The infection is transmitted through social interactions. While Northern European reported decrease FeLV among pet cats, Switzerland’s rates remain stagnant at 2.7% (2016/17: 95% CI 1.4–5.2%). Research on Swiss stray has been lacking, even though these animals could serve as reservoir. Sampling that do not receive regular veterinary care can be challenging. Collaboration with the Network for Animal Protection (NetAP) allowed prospective collection of saliva samples from 1711 during trap–neuter–return program 2019 2023. These were tested RNA using RT-qPCR measure antigenemia. Viral was detected 4.0% (95% 3.1–5.0%) samples, 7.7% 4.9–11.3%) sick 3.3% 2.4–4.4%) healthy ones. We identified three geographically independent hotspots alarmingly high (up 70%). Overall, including previous data privately owned FeLV-positive scattered throughout Switzerland 24/26 cantons. Our findings underscore welfare concerns infections lacking attention, highlighting potential risk other free-roaming those owned. This emphasizes critical significance vaccinating all outdoor access against developing programs protect infections.

Language: Английский

---

Highly pathogenic avian influenza (HPAI) H5 virus exposure in domestic cats and rural stray cats, the Netherlands, October 2020 to June 2023

Eurosurveillance, Journal Year: 2024, Volume and Issue: 29(44)

Published: Oct. 31, 2024

BackgroundHighly pathogenic avian influenza (HPAI) H5Nx and human H1N1pdm2009 viruses can infect cats. Infections in cats may result viral adaptations or recombinant viruses, which facilitate zoonotic transfer.AimWe aimed to investigate the presence of HPAI H5 clade 2.3.4.4 H1 antibodies these domestic rural stray Netherlands factors associated with exposure.MethodsSera from cats, sampled 2020-2023, were analysed by ELISA confirmed hemagglutination inhibition assay (HAI) pharyngeal swabs lung tissue for A virus RT-qPCR.ResultsIn 701 83 (11.8%; 95% confidence interval (CI): 9.5-14.5) sera positive 65 findings confirmed. In HAI, two both H1. 871 four (0.46%; CI: 0.13-1.2) none but 40 (4.6%; 3.3-6.2) seropositive 26 Stray living nature reserves (odds ratio (OR) = 5.4; 1.5-20.1) older (OR 3.8; 2.7-7.1) more likely be seropositive. No was detected 230 cats.ConclusionThe higher seroprevalence compared suggests frequent exposure, most due foraging on wild birds. contrast, exposure common

Language: Английский

---

Feline Lymphoma: Patient Characteristics and Response Outcome of the COP-Protocol in Cats with Malignant Lymphoma in The Netherlands

Animals, Journal Year: 2023, Volume and Issue: 13(16), P. 2667 - 2667

Published: Aug. 18, 2023

Feline lymphoma is currently less commonly associated with retrovirus infections as the feline leukemia virus (FeLV) and immunodeficiency (FIV). This thought to have caused a shift in distribution of anatomical subtypes eventually led poorer treatment outcomes. The aim this study was evaluate whether change also notable Netherlands, country historically known for its low prevalence FeLV FIV, determine consequences on response. A 10-year cohort 174 cats large cell (110 treated) were included compared historical data from previously published reports Netherlands. Of 90 screened, only one tested positive three FIV. most current had an increased age (median 8.7 years) fever Siamese (6.3%) previous reports, alimentary (24.5%) nasopharyngeal (22.7%) being common subtypes. Sixty-six hundred ten (60%) went into complete remission, (CR) resulting median disease-free period (DFP) 763 days, mediastinal having longest DFP. overall survival time 274 days estimated 1-year 41.3% 2-year 34.6%, respectively. Patient characteristics malignant Netherlands changed over years, but cannot be explained by differences FeLV/FIV prevalence. Although response rate therapy did not time, some subtypes, longer DFPs observed 30 years ago.

Language: Английский

---

Cats as a sentinel species for human infectious diseases – toxoplasmosis, trichinellosis, and COVID-19

Current Research in Parasitology and Vector-Borne Diseases, Journal Year: 2024, Volume and Issue: 6, P. 100196 - 100196

Published: Jan. 1, 2024

In this study, serological screening for

Language: Английский

---

Characterization of monoclonal antibodies targeting SARS-CoV-2 spike glycoprotein: Reactivity against Delta and Omicron BA.1 variants

Journal of Virological Methods, Journal Year: 2024, Volume and Issue: 330, P. 115027 - 115027

Published: Aug. 30, 2024

Language: Английский

---

Are unlicensed feline coronavirus antiviral compounds GS-441524 and GC376 what they claim to be? A qualitative and quantitative analysis.

Published: Sept. 14, 2023

Feline infectious peritonitis (FIP) caused by feline coronavirus was, until recently, considered both fatal and untreatable. Experimental antivirals such as GS-441524 GC376 can be obtained off-label through crowdsourced internet groups have been used pet owners to treat FIP. We describe analysis characterization of unregulated batches

Language: Английский

---