SARS-COV-2 INFECTION DURING PREGNANCY AND RISK OF PREECLAMPSIA: A SYSTEMATIC REVIEW DOI Creative Commons

Martin Gabe Tua Sihotang

Journal of Advance Research in Medical & Health Science (ISSN 2208-2425), Journal Year: 2023, Volume and Issue: 9(12), P. 152 - 159

Published: Dec. 22, 2023

Background: The concurrence of pregnancy-related diseases (gestational hypertension, preeclampsia and eclampsia) with the COVID-19 virus is a clinical novelty, classified as serious maternal risk. 1 2 A living systematic review meta-analysis in pregnant recently women reported severe infection 9 intensive care unit admission required 4%; invasive ventilation used extracorporeal membrane oxygenation administered 0.2 aim: This study aims to show about SARS-CoV-2 during pregnancy risk preeclampsia. Methods: By comparing itself standards set by Preferred Reporting Items for Systematic Review Meta-Analysis (PRISMA) 2020, this was able that it met all requirements. So, experts were make sure up-to-date possible be. For search approach, publications came out between 2013 2023 taken into account. Several different online reference sources, like Pubmed SagePub, do this. It decided not take account pieces, works had already been published, or only half done. Result: In PubMed database, results our brought up 99 articles, whereas on SagePub 66 articles. conducted last year yielded total 98 articles 36 SagePub. result from title screening, 16 end, we compiled 8 papers. We included five research criteria. Conclusion: characteristics SARS-CoV-2-infected preeclamptic seem be more less similar regard proteinuria, elevated liver enzymes, thrombocytopenia, increased pro-inflammatory markers. Hence, diagnosis could quite difficult.

Language: Английский

Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures DOI Creative Commons
Nataly Stylianou, Ismail Sebina, Nicholas Matigian

et al.

Clinical & Translational Immunology, Journal Year: 2024, Volume and Issue: 13(2)

Published: Jan. 1, 2024

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as 'preeclampsia-like syndrome'. However, the mechanisms underpinning SARS-CoV-2-induced malfunction are still unclear. Here, we investigated whether transcriptional architecture placenta altered response SARS-CoV-2 infection.

Language: Английский

Citations

9
Preeclamptic Placental CD19+ B Cells Are Causal to Hypertension During Pregnancy DOI
Owen Herrock, Nathan Campbell, Evangeline Deer

et al.

Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

BACKGROUND: Patients with preeclampsia exhibit hypertension and chronic inflammation characterized by CD (cluster determinant) 4+T cells, B cells secreting AT1-AA (agonistic autoantibody against the angiotensin II type 1 receptor), inflammatory cytokines, complement activation. Importantly, a history of COVID-19 during pregnancy is associated an increased incidence preeclampsia-like phenotype partly mediated CD4+T cells. We recently showed pregnant patients or without produce AT1-AA, indicating importance lymphocytes in progression possibly COVID-19. Therefore, we hypothesize that from induce through AT1-AA. METHODS: Placental were isolated normal pregnant, preeclampsia, normotensive history, at delivery. Then, 3×10 5 transferred intraperitoneally into athymic rats gestational day 12. On 18, carotid catheters inserted. 19, mean arterial pressure was measured, tissues collected. RESULTS: Preeclampsia B-cell recipients had significantly pressure, activation compared recipients. Recipients markers but not to level significance as Inhibition attenuated occurred response history. CONCLUSIONS: This study demonstrates important role contributing secretion

Language: Английский

Citations

1
Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1–7)/MasR signaling in normal and hypertensive pregnancy DOI Creative Commons

Caroline R. Clark,

Raouf A. Khalil

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 220, P. 115963 - 115963

Published: Dec. 5, 2023

Language: Английский

Citations

14
Placental Drug Delivery to Treat Pre‐Eclampsia and Fetal Growth Restriction DOI Creative Commons
Venkataraman Deepak,

Lujain El‐Balawi,

Lynda K. Harris

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Pre-eclampsia and fetal growth restriction (FGR) continue to cause unacceptably high levels of morbidity mortality, despite significant pharmaceutical technological advances in other disease areas. The recent pandemic has also impacted obstetric care, as COVID-19 infection increases the risk poor pregnancy outcomes. This review explores reasons why it lacks effective drug treatments for placental dysfunction that underlies many common conditions describes how nanomedicines targeted delivery approaches may provide solution current drought. ever-increasing range biocompatible nanoparticle formulations available is now making possible selectively deliver drugs uterine tissues dramatically limit transfer. Formulations are refractory uptake offer possibility retaining within maternal circulation, allowing pregnant individuals take medicines previously considered too harmful developing baby. Liposomes, ionizable lipid nanoparticles, polymeric adenoviral vectors have all been used create efficacious systems use pregnancy, although each approach offers distinct advantages limitations. It imperative be built upon there an overdue investment intellectual financial capital this field.

Language: Английский

Citations

3
Pilot Study on Evaluating the Impact of Tetanus, Diphtheria, and Pertussis (Tdap), Influenza, and COVID-19 Vaccinations on Antibody Responses in Pregnant Women DOI Creative Commons
Wei‐Chun Chen,

Shu-Yu Hu,

Chao‐Min Cheng

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(3), P. 312 - 312

Published: March 15, 2024

This study assessed IgG levels to influenza/pertussis and neutralizing antibody (Nab) responses of COVID-19 vaccines in blood pregnant women following immunization with pertussis (Tdap), influenza, vaccines. We prospectively collected 71 participants categorized by the vaccine combinations: 3TI, 4TI, 3T, 4T groups (three four doses plus Tdap/influenza or Tdap alone). Our findings have indicated that 3TI group exhibited elevated for influenza B compared 3T (12.90 vs. 7.75 U, p = 0.001); this pattern was not observed A. Pertussis remained uniform across all groups. The 4TI demonstrated a greater Nab inhibition rate from both (61.34% 22.5% 15.16%, respectively, 0.001). no correlation between Tdap/influenza, exception moderate group. efficacy consistent, regardless administration Interestingly, without vaccine, three still offered protection against A, but B. Hence, co-administering COVID-19, during prenatal care maintains immunogenicity is highly advised safeguard fully.

Language: Английский

Citations

1
Impact of the Covid-19 pandemic on the maternal mortality rate in Brazil: trend and spatial distribution DOI Creative Commons
Izabel Cristina da Silva Carvalho, Márcio Dênis Medeiros Mascarenhas, Malvina Thaís Pachêco Rodrigues

et al.

Revista gaúcha de enfermagem, Journal Year: 2024, Volume and Issue: 45

Published: Jan. 1, 2024

To analyze the impact of Covid-19 pandemic on Maternal Mortality Ratio in Brazil from 2018 to 2021.

Language: Английский

Citations

1
Placental Disorders as a Risk Factor for the Development of Postpartum Haemorrhage DOI Open Access
T. Е. Belokrinitskaya, A.G. Sidorkina, В.А. Мудров

et al.

Fundamental and Clinical Medicine, Journal Year: 2024, Volume and Issue: 9(2), P. 86 - 93

Published: June 21, 2024

The placenta is a functional link between mother and fetus during pregnancy the most important factor determining newborn infant health. Postpartum hemorrhage leading cause of maternal morbidity mortality worldwide affected by numerous factors including placental size. Here we analysed role disorders as risk for development postpartum hemorrhage. We screened available literature via PubMed, PubMed Central, Scopus, MEDLINE, ScienceDirect, Cochrane Library, eLibrary from 2001 to October 2023. Placental insufficiency may either hyperplasia (i.e., expansion meet nutritional needs growing fetus) or hypoplasia, which deficiency in nutrients oxygen slows down fetal growth development. Both these conditions significantly affect probability volume haemorrhage.

Language: Английский

Citations

0
COVID-19 in Pregnancy: An Update for Clinicians DOI
Claire H. Packer,

Malavika Prabhu

Clinical Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 67(3), P. 565 - 575

Published: July 5, 2024

In this review, we will discuss the risks of COVID-19 on maternal, obstetric, and neonatal outcomes. We also review safety vaccination in pregnancy, as well management pregnancy.

Language: Английский

Citations

0
Characterization of COVID-19 infected pregnant women with ICU admission and the risk of preterm: a cluster analysis DOI Creative Commons
Antonio Sarría‐Santamera,

Nurly Kapashova,

Radmir Sarsenov

et al.

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 17(12), P. 102572 - 102572

Published: Oct. 30, 2024

Language: Английский

Citations

0
SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: A Cohort Study of Pregnant People in a Maternity Hospital in Rio de Janeiro, Brazil DOI Creative Commons
Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhães de Oliveira

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Early in the COVID-19 pandemic, there was no evidence that posed greater risk to pregnant people. Over subsequent year, it became clear pregnancy rendered more at higher of severe COVID-19. There is, however, a paucity data regarding perinatal outcomes low-middle income countries (LMIC). The aim this study evaluate effect SARS-CoV-2 infection on adverse maternal and reference maternity hospital, low setting Rio de Janeiro during pandemic. Methods conducted prospective cohort 1,185 people ≥ 16 years admitted hospital their infants from March 2020 2022. Participants with laboratory confirmed SARS CoV-2 were considered infected. An exploratory analysis qualitative variables absolute relative frequencies 95% confidence intervals calculated. Survival functions estimated by Kaplan-Meier method, Cox proportional hazards model employed interpret effects time outcomes, adjusted for vaccination, comorbidity gestational trimester. Results A total 21% (249/1185) patients infected SARS-CoV-2, median age 26 (range: 16–47). Cesarean section deliveries performed 54% (135/249) + participants vs 41.7% (391/936) uninfected, p = < 0.001. vertical transmission observed 6 169 (3.6%) tested neonates. Preterm occurred frequently testing positive (30.7% 23.6). In survival analysis, prematurity (HR: 0.85, CI: 0.66–1.11) including fetal distress 0.94, 0.59–1.49); stillbirth 0.84, IC: 0.42–1.71) neonatal death 0.91, 0.39–2.14), even after adjusting trimester infection. Intensive care unit admission and/or 68 1185 (5.7%); 44 249 (17.7%) vs. 24 936 uninfected (2.5%). Patients (crude HR: 6.12, 3.70-10.14; 5.60, 3.35–9.37) than participants. All 21 who died unvaccinated against Conclusion due highlights need adequate preventive measures, particularly prenatal postpartum periods.

Language: Английский

Citations

0