Current knowledge on the epidemiology and detection methods of hepatitis E virus in China DOI Creative Commons

Bo-fang Duan,

Yuan Feng

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 26, 2024

Hepatitis E is recognized as a significant zoonotic disease burden in China, with the hepatitis virus (HEV) identified etiological agent responsible for this disease. HEV exhibits no specific host tropism, which facilitates its transmission among various mammalian species, including humans, pigs, cattle, goats, and others. Currently, availability of effective therapeutic agents vaccines infection limited. Therefore, comprehensive understanding epidemiological characteristics HEV, existing detection methods, crucial prevention control. In review, we provide an overview current knowledge on mainly focusing strategies, molecular characteristics, prevalence pathogen human population other susceptible species. This review will be useful to enhance public awareness accelerate control efforts future.

Language: Английский

Targeted Enrichment Sequencing Utilizing a Respiratory Pathogen Panel for Genomic Wastewater-Based Viral Epidemiology in Uruguay DOI Creative Commons
Florencia Cancela, Andrés Lizasoain, Yanina Panzera

et al.

Food and Environmental Virology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 9, 2025

Language: Английский

Citations

0
Sentinel Surveillance: Hepatitis E and the Case for Domestic Animal Surveillance DOI Creative Commons

Andrea Grzybowski,

William Sörensen,

Sharon Phillips

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Globalization and geoclimatic changes are driving the emergence spread of infectious diseases. Today, nearly two thirds emerging Infectious diseases zoonotic in nature (75% originating wildlife). Despite individuals generally having little contact with wildlife (or livestock), public health continues to rely on reactionary surveillance humans livestock track disease incidence prevalence. It is only after pathogen has spilled over from wild animal hosts, established itself among human or populations, become a cause morbidity mortality, that most current systems able detect track. This chapter examines role dogs may play sentinel system hepatitis E humans. based seroprevalence study Texas. In this study, total 144 were sampled three different types care facility. The overall Hepatitis prevalence was 48%. type facility significantly associated infection rates. We explore utility systems, yet circle back domestic surveillance, specifically (genotypes 3/4) dogs, as both an early warning baseline monitoring allows practitioners across globe address before outbreaks occur.

Language: Английский

Citations

0
Prevalence of hepatitis A and E viruses in wastewater in Asian countries DOI Creative Commons

Sunayana Raya,

Sarmila Tandukar,

Hari Prasad Kattel

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175473 - 175473

Published: Aug. 12, 2024

Hepatitis A and E viruses (HAV HEV, respectively) remain a significant global health concern despite advancements in healthcare vaccination programs. Regular monitoring vaccine efficacy of HAV are still lacking different countries. This study aimed to investigate HEV prevalence developed, developing, least-developed Asian countries using wastewater as surveillance tool. total 232 untreated samples were collected from six treatment plants, sewage plant, or an open drainage [Nepal (n = 51), Indonesia 37), Thailand 30), Vietnam 27), the Philippines 17), Japan 70)] between April October 2022. Viruses concentrated by simple centrifugation polyethylene glycol precipitation method, followed viral RNA extraction reverse transcription-quantitative polymerase chain reaction. detected Nepal (51 % for 2 HEV), (3 both viruses), (1 24 HEV). Only was found 11 Indonesia, whereas only Philippines, with positive ratio 15 12 %, respectively. These results highlighted geographic variability prevalence, underscoring need localized public strategies address specific hepatitis challenges each country.

Language: Английский

Citations

3
Integrated hepatitis e virus monitoring in central Argentina: a six-year analysis of clinical surveillance and wastewater-based epidemiology DOI
Anabella Clara Fantilli, Gisela Masachessi, Guadalupe Di Cola

et al.

Water Research, Journal Year: 2024, Volume and Issue: 261, P. 122004 - 122004

Published: June 27, 2024

Language: Английский

Citations

2
SEROLOGICAL STATUS OF HUNTERS AND THEIR FAMILY MEMBERS IN RELATION TO RISK OF HEV INFECTIONS DOI Creative Commons
Małgorzata Tokarska-Rodak,

Andżelika Dyrda,

Patrycja Andrzejuk

et al.

Health Problems of Civilization, Journal Year: 2024, Volume and Issue: 18(4), P. 375 - 382

Published: Jan. 1, 2024

AMA Tokarska-Rodak M, Dyrda A, Andrzejuk P, et al. SEROLOGICAL STATUS OF HUNTERS AND THEIR FAMILY MEMBERS IN RELATION TO RISK HEV INFECTIONS. Health Problems of Civilization. 2024. doi:10.5114/hpc.2024.139725. APA Tokarska-Rodak, M., Dyrda, A., Andrzejuk, P., Plewik, D., Szepeluk, & Paszkiewicz, J. (2024). https://doi.org/10.5114/hpc.2024.139725 Chicago Małgorzata, Andżelika Patrycja Dorota Adam Justyna and Marta Zarębska "SEROLOGICAL INFECTIONS". Harvard J., Zarębska, Pańczuk, A. MLA Małgorzata INFECTIONS." Civilization, Vancouver Plewik D, Szepeluk Paszkiewicz J

Citations

0
Seroprevalence of swine hepatitis E virus and the farmers’ potential risk of infection in the Province of Bali, Indonesia DOI Creative Commons
I Made Kardena, Anak Agung Gde Oka Dharmayudha, I Wayan Nico Fajar Gunawan

et al.

Veterinary World, Journal Year: 2024, Volume and Issue: unknown, P. 1810 - 1820

Published: Aug. 1, 2024

Background and Aim: Hepatitis E virus (HEV) infection formerly predominantly occurred in rural areas. However, it has recently been spread to urban peri-urban This study aimed estimate the seroprevalence of HEV pigs collected from areas Bali. The potential pig farmers’ risk level for being exposed transmitted them association with their pig-rearing practices was also assessed. Materials Methods: A total 183 68 herds were sampled this study, 91 Denpasar as representative samples 92 Karangasem Regency Sera immunoglobulin G antibodies against detected using a commercial enzyme-linked immunosorbent assay. questionnaire prepared interviewing farmers. Bivariable multivariable logistic regression analyses performed identify putative factors associated seropositivity. Meanwhile, risk-incurring farmers assessed by scoring responses interview. Results: Overall, 23.5% (43/183) (95% confidence interval [CI]: 17.6–30.3) sera tested have HEV. Among herds, 36.8% (25) CI: 25.4–49.3) had at least one each herd. Pigs 5 times (Odds ratio [OR] 5.34, 95% 2.27–13.54, p < 0.001) more likely be seropositive than Denpasar. no difference found seropositivity between (p = 0.05). In assessing rearing management factors, 3 (OR 3.0, 1.07–8.52, 0.05) rear economic investment compared Karangasem. Regarding anticipating diseases that can humans, 6 5.72, 1.48–26.7, 0.0074) anticipate zoonotic Similarly, 3.29, 1.08–10.23, 0.035) could humans Pig 4 odds 4.49, 1.11–18.19, 0.03) washing hands after going pigpens All participants categorized high exposure transmission. Conclusion: IgG among reared those suggests transmission these is not negligible. To minimize risk, public education on diseases, including infection, transmission, prevention, needs implemented particularly targeted local Keywords: Bali, hepatitis virus, pigs, seroprevalence.

Language: Английский

Citations

0
Strain- and Subtype-Specific Replication of Genotype 3 Hepatitis E Viruses in Mongolian Gerbils DOI Creative Commons
Tian‐Cheng Li, Yusuke Sakai, Yasushi Ami

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(10), P. 1605 - 1605

Published: Oct. 12, 2024

Since Mongolian gerbils are broadly susceptible to hepatitis E virus (HEV), including genotypes 1, 4, 5, and 8 (HEV-1, HEV-5, HEV-8) rat HEV, they a useful small animal model for HEV. However, we have observed that the subtypes HEV-3k HEV-3ra in genotype 3 HEV (HEV-3) were not infected efficiently gerbils. A small-animal HEV-3 is also needed since responsible major zoonotic infections. To investigate whether can be used as models other of HEV-3, injected with five (HEV-3b, -3e, -3f, -3k, -3ra) compared infectivity subtypes. We detected viral RNA gerbils' feces. High titers anti-HEV IgG antibodies serum induced all HEV-3b/ch-, HEV-3f-, HEV-3e-injected Especially, animals released high levels viruses into their feces an extended period. The replication was limited HEV-3b/wb-injected HEV-3k-injected groups. Although HEV-3ra-injected gerbils, copy numbers fecal specimens low; no sera. These results indicate although HEV-3's depends on subtype strain, potential HEV-3. further comparison HEV-3e different strains (HEV-4i HEV-5) genera (rat HEV) revealed ALT elevations among strains, liver damage occurred HEV-4i- HEV-5-infected but HEV-3e- or HEV-infected demonstrating variable pathogenicity across HEVs from might candidate examine HEV's pathogenicity.

Language: Английский

Citations

0
Cell Culture of a Swine Genotype 4 Hepatitis E Virus Strain DOI
Ga Gong,

Jiaojiao Xin,

Y.C. Lou

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(11)

Published: Nov. 1, 2024

ABSTRACT HEV infection has become a global health concern. The study of pathogenicity been hindered by the lack suitable in vitro culture system. In present research, we systematic demonstration efficient replication swine GT4 A549 cells, Huh‐7 and HepG2/C3A cell lines. results immunofluorescence assay confocal showed that is efficiently replicated three lines at 72 h postinoculation. Meanwhile, also detected virus titer quantified were increased 2‐, 6,‐ 11‐days Moreover, successfully observed particles suspension 6 days This finding holds significance for advancing studies.

Language: Английский

Citations

0
Current knowledge on the epidemiology and detection methods of hepatitis E virus in China DOI Creative Commons

Bo-fang Duan,

Yuan Feng

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 26, 2024

Hepatitis E is recognized as a significant zoonotic disease burden in China, with the hepatitis virus (HEV) identified etiological agent responsible for this disease. HEV exhibits no specific host tropism, which facilitates its transmission among various mammalian species, including humans, pigs, cattle, goats, and others. Currently, availability of effective therapeutic agents vaccines infection limited. Therefore, comprehensive understanding epidemiological characteristics HEV, existing detection methods, crucial prevention control. In review, we provide an overview current knowledge on mainly focusing strategies, molecular characteristics, prevalence pathogen human population other susceptible species. This review will be useful to enhance public awareness accelerate control efforts future.

Language: Английский

Citations

0