Contribution of genomic surveillance in the detection and monitoring of SARS variants- CoV-2 during the 6 pandemic waves in the Central African Republic from 2020 to 2023

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 22, 2024

Objective: The Covid-19 pandemic has highlighted the need to strengthen diagnosis and genomic surveillance capacities. The Central African Republic was able manage 5 waves during health monitoring integrated as a tool in 2021. aim of this study is report data from National Laboratory Clinical Biology Public Health describe landscape circulation SARS-CoV-2 variants. Materials methods: This retrospective, descriptive observational over period 3 years (ranging April 2020 November 2023) carried out on population consenting volunteers, throughout CAR, tested by RT -PCR nasopharyngeal samples with sufficient information LNBCSP databases. Sequencing largely at INRB KINSHASA May 2023 LNBCSP. Results discussion: Out 97,864 RT-PCR tests out, 9,764 came back positive, which corresponds prevalence 9.98%. average age patients 39.97 ± 13.76 sex ratio M/F 2.12. positivity significantly associated (p=0.001), (p=0.013) clinical manifestations. Ten variants circulated recorded. circulating dominated Omicron (B.1.1.529), Delta (B.1.617.2) especially B.1.620 B.640 marked second wave CAR. Conclusion: retrospective series provides key for understanding history Risk factors are identified variant described. Strengthening national capacities would help country adopt better response against pandemic.

Language: Английский

Mass Screening Using Antigenic and Molecular Diagnostic Tests of COVID-19 in Bangui at the Beginning of the Second Wave in July 2021

Journal of Tuberculosis Research, Journal Year: 2024, Volume and Issue: 12(01), P. 1 - 12

Published: Jan. 1, 2024

Objective: COVID-19 surveillance was established as early March 2020 in the Central African Republic (CAR), after WHO statement relating to identification of several cases outside China. However, given non-performing molecular biology technical platform many developing countries sub-Saharan Africa, second wave promised be surprising and formidable. In this context, a mass survey launched Bangui determine prevalence COVID-19. Patients Methods: From 18 April 2, 2021, screening campaign took place tourist places, companies main hospital infrastructures. Nasopharyngeal swab samples were collected from participants with without symptoms Influenza-like illness (ILI) stored VTM tubes. The Ag (COVID-19) RT-PCR tests carried out at LNBCSP. sequencing SARS-CoV-2 positives INRB. Results: We included 1480 whom 33 (2.23%) SARS-COV-2 positive, 24 male 9 female. This sex difference statistically significant (p = 0.012) ratio M/F 1.09. Sampling sites located 1st arrondissement most prolific 0.006) sequenced. addition analysis predefined under study, 17 control sequences provinces generated during same period are added. detected 2 Variants Of Concern (VOC) including predominant B.1.620 (43.86%) followed by B.1.1.7 or Alpha (5.10%). Conclusion: study showed importance availability means diagnosis identified risk factors sampling site. has shown setting up sentinel for all regions country appropriate use anti-COVID-19 vaccine.

Language: Английский

Contribution of Genomic Surveillance in the Detection and Monitoring of SARS-CoV-2 Variants during the 6 Pandemic Waves in the Central African Republic from 2020 to 2023

Journal of Tuberculosis Research, Journal Year: 2024, Volume and Issue: 12(03), P. 151 - 164

Published: Jan. 1, 2024

Language: Английский