Risk factors for bloodstream infection in COVID-19 patients in intensive care units: a systematic review and meta-analysis

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 3, 2025

Abstract Background Risk factors for bloodstream infection in patients with COVID-19 the intensive care unit (ICU) remain unclear. The purpose of this systematic review was to study risk BSI admitted ICUs COVID-19. Methods A search performed on PubMed, EMBASE, Cochrane Library, and Web Science up July 2024. Data were reported as combined odds ratio (OR) categorical variables weighted mean difference (WMD) continuous variables. Results 6914 studies retrieved, which 55 included meta-analysis. Men (OR = 1.28, 95% CI: 1.10–1.50, P 0.006), high SAPS II score (WMD 6.43, 0.23–12.63, 0.042), diabetes 1.34, 1.04–1.73, 0.022), tracheal intubation 8.68, 4.68–16.08, < 0.001), mechanical ventilation 22.00, 3.77-128.328, ECMO 2.70, 1.17–6.26, 0.020), central venous cannulation 9.33, 3.06–28.43, prolonged ICU stay 10.37, 9.29–11.44, methylprednisolone use 2.24, 1.24–4.04, 0.008), combination Tocilizumab 4.54, 1.09–18.88, 0.037) ICU-BSI patients. Conclusion We identified 10 In future studies, these can be establish a more comprehensive accurate prediction model Targeted measures taken earlier control BSI.

Language: Английский

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Corticosteroids and rising tide in femoral head avascular necrosis following COVID-19: A critical analysis

The European Research Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: Feb. 17, 2025

Objectives: During the COVID-19 pandemic, increased corticosteroid use to treat severe cases has been linked a rise in femoral head avascular necrosis (FHAVN) post-recovery. This study evaluated FHAVN patients referred an outpatient clinic after COVID-19, focusing on severity of related use, and aimed connect drug dosage, disease grade. Methods: The was prospectively designed. Patients diagnosed with who received corticosteroids for were included. Data collected included demographic information, medical history, magnetic resonance imaging results radiological grading. Results: A total 48 evaluated, mean age 46.13 years. significant majority (81.3%) respondents had bilateral FHAVN. prednisolone equivalent dose 1295.16±857.98 mg over approximately 18 days. found positive correlation between dosage treatment time. Conclusions: findings indicate that is correlated use. Although have shown benefits cases, their prolonged high-dose administration poses risks, including development

Language: Английский

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Bacteriemia asociada a catéter venoso central en el paciente crítico: epidemiología y factores de riesgo

Enfermería Intensiva, Journal Year: 2025, Volume and Issue: 36(3), P. 500538 - 500538

Published: April 6, 2025

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Patterns of corticosteroid use among remdesivir and matched patients and associated clinical outcomes in hospitalized COVID-19 patients

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(2), P. 215 - 222

Published: Jan. 22, 2024

Introduction We aimed to investigate patterns of corticosteroid use and their relationship with remdesivir clinical outcomes in a large real-life cohort COVID-19 patients treated tertiary-level institution.

Language: Английский

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Thrombotic Long-Term Consequences of SARS-CoV-2 Infection in Patients with Compensated Cirrhosis: A Propensity Score-Matched Analysis of a U.S. Database

Diseases, Journal Year: 2024, Volume and Issue: 12(7), P. 161 - 161

Published: July 17, 2024

Background: Cirrhosis causes an imbalance in the coagulation pathway and leads to a tendency for both bleeding clotting. SARS-CoV-2 has been reported be associated with hypercoagulable state. This study examines SARS-CoV-2’s impact on hemostasis compensated patients cirrhosis. Methods: We analyzed US Collaborative Network, which comprises 63 HCOs U.S.A. Compensated cirrhosis were split into two groups: SARS-CoV-2-positive -negative. Patients’ baseline characteristics used 1:1 propensity score-matched module create comparable cohorts. compared risk of portal vein thrombosis (PVT), deep venous (DVT), pulmonary embolism (PE) at 6 months, 1 3 years. Results: Of 330,521 patients, 27% tested positive 73% remained negative. After PSM, cohorts included 74,738 patients. Patients had higher rate PVT those without months (0.63% vs 0.5%, p < 0.05), year (0.8% 0.6%, years (1% vs. 0.7%, DVT 0.4%, (1.4% 0.8%, PE (0.6% 0.3%, (0.7% 0.05). Conclusions: The presence infection was PVT, DVT,

Language: Английский

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Negative Prognostic Associations of Selective Serotonin Reuptake Inhibitors Use in Hospitalized COVID-19 Patients and Potential Contribution of Cardiovascular Comorbidities

Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: July 31, 2024

<b><i>Introduction:</i></b> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a causative agent of disease 2019 (COVID-19), very contagious systemic dominantly affecting the tract. Recent findings oppose earlier suggestions that selective serotonin reuptake inhibitors (SSRIs) might be protective during SARS-CoV-2 infection, prompting current study. <b><i>Methods:</i></b> The institutional registry tertiary referral center was retrospectively evaluated for SSRI use and associated clinical outcomes among hospitalized COVID-19 patients with mostly severe critical disease. <b><i>Results:</i></b> Among 1,558 patients, there were 78 (5%) exposed to hospitalization. users in comparison non-users did not significantly differ their demographic characteristics, comorbidity profile or severity symptoms inflammatory response at admission. In multivariate analyses adjusted clinically meaningful variables, higher risks death, mechanical ventilation, intensive care unit treatment, bacteremia, whereas no significant relationship venous, arterial thrombosis, major bleeding present. Patients less initial presentation, lower burden, platelet count, cumulative presence hyperlipidemia, atrial fibrillation, chronic heart failure nonexposed acetylsalicylic-acid had mortality use. <b><i>Conclusions:</i></b> Findings study validate but also report tendency deterioration, bacteremia patients. These suggest potential contribution cardiovascular comorbidities detrimental course

Language: Английский

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Risk factors for bloodstream infection in COVID-19 patients in intensive care units: A systematic review and meta-analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Background: Risk factors for bloodstream infection in patients with COVID-19 the intensive care unit (icu) remain unclear. The purpose of this systematic review was to study risk BSI admitted ICUs COVID-19. Methods: A search performed on PubMed, EMBASE, Cochrane Library, and Web Science up July 2024. Data were reported as combined odds ratio (OR) categorical variables weighted mean difference (WMD) continuous variables. Results: 6914 studies retrieved, which 55 included meta-analysis. Men (OR=1.28, 95% CI: 1.10-1.50, P=0.006), high SAPS II score (WMD=6.43, 0.23-12.63, P=0.042), diabetes (OR=1.34, 1.04-1.73, P=0.022), tracheal intubation (OR=8.68, 4.68-16.08, P<0.001), mechanical ventilation (OR=22.00, 3.77-128.328, ECMO (OR=2.70, 1.17-6.26, P=0.020), central venous cannulation (OR=9.33, 3.06-28.43, prolonged ICU stay (WMD=10.37, 9.29-11.44, methylprednisolone use (OR=2.24, 1.24-4.04, P=0.008), combination Tocilizumab (OR=4.54, 1.09-18.88, P=0.037) ICU-BSI patients. Conclusion:We identified 10 In future studies, these can be establish a more comprehensive accurate prediction model Targeted measures taken earlier control BSI.

Language: Английский

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