Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 190, P. 109973 - 109973
Published: April 3, 2025
Language: Английский
Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 124 - 124
Published: Jan. 9, 2025
The re-emergence of the Nipah virus (NiV) in Kerala, India, following tragic death a 14-year-old boy, underscores persistent threat posed by zoonotic pathogens and highlights growing global public health challenge. With no vaccine or curative treatment available, fatality rates as high 94% past outbreaks, is critical concern for authorities worldwide. Transmitted primarily through contact with fruit bats consumption contaminated food, well direct human-to-human transmission, NiV remains highly lethal unpredictable pathogen. World Health Organization has classified priority pathogen due to its alarming potential cause widespread outbreaks even trigger next pandemic. Recent India Bangladesh, occurring seasonal regularity, have once again exposed vulnerability systems containing this virus. This study explores epidemiology, ecological factors driving response NiV, emphasizing role spillovers pandemic preparedness. As community grapples an increasing number emerging infectious diseases, stands stark reminder importance coordinated surveillance, rapid containment measures, urgent development novel strategies mitigate impact re-emerging threat.
Language: Английский
Citations
3
Virus Evolution, Journal Year: 2024, Volume and Issue: 10(1)
Published: Jan. 1, 2024
Nipah virus (NiV) is an emerging pathogen that causes encephalitis and a high mortality rate in infected subjects. This systematic review aimed to comprehensively analyze the global epidemiology research advancements of NiV identify key knowledge gaps literature. Articles searched using literature databases, namely PubMed, Scopus, Web Science, Science Direct yielded 5,596 articles. After article screening, 97 articles were included this review, comprising 41 epidemiological studies 56 developments on NiV. The majority conducted Bangladesh, reflecting country's significant burden outbreaks. initial outbreak was identified Malaysia 1998, with subsequent outbreaks reported India, Philippines. Transmission routes vary by country, primarily through pigs Malaysia, consumption date palm juice human-to-human India. However, availability genome sequences remains limited, particularly from Mortality rates also according exceeding 70% Philippines, less than 40% Malaysia. Understanding these differences among countries crucial for informing enhancing prevention management strategies. In terms developments, focused vaccine development, followed phylogenetic analysis antiviral research. While many vaccines antivirals have demonstrated complete protection animal models, only two progressed clinical trials. Phylogenetic analyses revealed distinct clades between proposals classify India as separate strain Bangladesh. Taken together, comprehensive OneHealth approaches integrating disease surveillance are imperative future studies. Expanding dataset sequences, will be pivotal. These efforts essential advancing our understanding pathogenicity developing robust diagnostic assays, therapeutics necessary effective preparedness response
Language: Английский
Citations
9
Viruses, Journal Year: 2025, Volume and Issue: 17(1), P. 81 - 81
Published: Jan. 9, 2025
Nipah virus (NiV) is a zoonotic pathogen with the potential to cause human outbreaks high case fatality ratio. In this systematic review and meta-analysis, available evidence on NiV infections occurring in healthcare workers (HCWs) was collected critically appraised. According PRISMA statement, four medical databases (PubMed, CINAHL, EMBASE, Scopus) preprint repository medRixv were inquired through specifically designed searching strategy. A total of 2593 entries identified; them, 16 studies included qualitative quantitative analysis detailing outcome infection HCWs estimates seroprevalence among professions. All reported data from Asian countries: Malaysia, Singapore, Bangladesh, India (States Kerala Bengal), Philippines. Seroprevalence estimated seven 0.00% (95%CI 0.00 0.10) for IgM-class antibodies 0.08% 0.72) IgG class-antibodies, but sampled did not report any seropositive cases. ratio 73.52% 34.01 99.74) calculated 10 studies. conclusion, present study shows that may result possible occupational involved managing incident As most occur limited resources settings, it reasonable even basic preventive measures (i.e., mandatory use PPE appropriate isolation cases physical distancing) be quite effective avoiding occurrence new HCWs.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 27, 2025
Abstract The Nipah Virus (NiV) is a zoonotic pathogen with the mortality rate of up to 75%, recurring in Asia over past two decades. Due increasing risk human transmission mediated by various intermediate hosts such as pigs and bats, it necessary produce an accurate reliable point-of-care molecular detection method for NiV field diagnosis. In this study, we designed pairs primers targeting conserved G P genes developed nucleic acid (POC-NAD) system integrating one-step RT-PCR, lateral flow immunoassay, microfluidic technologies. POC-NAD shows high specificity sensitivity, Limit Detection (LoD) 199.1 copies/rxn. aiming sequences enables simultaneous both NiV-M NiV-B strains. Continuous evaluation 21 simulated clinical samples demonstrated 100% concordance RT-PCR results. Lateral flow-based visualization improves display time legibility Additionally, chips or chambers offer disposable reagent containers consistent PCR amplification results across conditions. Therefore, diagnostic tool suitable real-time testing surveillance resource-limited environments.
Language: Английский
Citations
0
Expert Review of Vaccines, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Nipah virus is a high-consequence pathogen that causes sporadic outbreaks with high mortality, and there are currently no vaccines or therapeutics available for Nipah. Vaccine development against faces challenges due to its current epidemiology limited outbreak sizes, which impedes the feasibility of conducting vaccine efficacy trials focused on disease endpoints. We review progress candidates in human clinical highlight evaluating nature outbreaks, given epidemic potential implications pandemic preparedness. examine alternative regulatory pathways, including US FDA's Animal Rule EMA's conditional marketing authorization, permit approval based surrogate markers rather than data from large-scale Phase-3 trials. The need standardized immune emphasized, alongside calls international collaboration develop such endpoints manage stockpile strategies. recommend alignment among developers, regulators, global health stakeholders incentivize through as well ensuring preparedness via strategic stockpiling response targeted deployment
Language: Английский
Citations
0
Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 190, P. 109973 - 109973
Published: April 3, 2025
Language: Английский
Citations
0