What COVID-19 Vaccination Strategy Should Be Implemented and Which Vaccines Should Be Used in the Post-Pandemic Era?

Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1180 - 1180

Published: Oct. 17, 2024

COVID-19 vaccines have reduced the negative health and economic impact of pandemic by preventing severe disease, hospitalizations deaths. In new socio-economic normality, vaccination strategy can be universal or high-risk seasonal not seasonal, different used. The achieve greater herd immunity effects is associated with costs than strategy. each country, optimal must decided considering advantages disadvantages assessing costs, cost-effectiveness strategies. should implemented when objective program to greatest benefits from its incremental ratio lower EUR 30,000-50,000 per QALY LYG. use adapted targeting currently circulating variants SARS-CoV-2 necessary avoid immune escape emerging variants.

Language: Английский

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Safety, tolerability, and efficacy of intranasally-administered detoxified LTh(αK) in mild-to-moderate COVID-19 patients: A randomized, double-blinded, placebo-controlled phase 2 study

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: Nov. 29, 2024

The objective of the study was to assess safety, tolerability, and potential efficacy intranasally administered AD17002, a detoxified form Escherichia coli heat-labile enterotoxin, in treating individuals with mild-to-moderate coronavirus disease 2019 (COVID-19). In this randomized, double-blinded, placebo-controlled phase 2a study, total 30 adults aged 20–70 years COVID-19 were recruited from three medical centers Taiwan 2022–2023. trial comprised two cohorts, participants randomly assigned receive intranasal administrations either doses AD17002 immunomodulator or placebo formulation buffer. Outcome analyses conducted on intention-to-treat set, safety set that included all randomized exposed AD17002. proportion cycle threshold (Ct) ≥30 time recovery key symptoms assessed. An exploratory analyze integrity viral genome after treatment. Administering 20 μg times, at 1-week 1-day intervals, proved be safe well tolerated subjects COVID-19. demonstrated rapid positive outcome reducing load patients receiving Impact treatment further supported by analysis following enhancement clinical within 5 days symptom onset observed but did not achieve statistical significance. According results, administration safe, well-tolerated, potentially effective for

Language: Английский

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Efficacy and Safety of Acupuncture for Post–COVID-19 Insomnia: Protocol for a Systematic Review and Meta-Analysis (Preprint)

Published: Nov. 29, 2024

The COVID-19 pandemic has had a profound global impact, leading to range of persistent sequelae referred as post–COVID-19 condition or “long COVID” that continue affect patients worldwide. Among these sequelae, insomnia (PCI) emerged significant issue. Conventional treatments, including cognitive behavioral therapy and pharmacological interventions, face limitations such variable efficacy, potential side effects, substantial costs. Recently, acupuncture gained traction due its cost-effectiveness, safety profile. This study aims conduct meta-analysis systematic review evaluating the efficacy for treatment PCI delineate optimal modality, intervention frequency, duration achieving most beneficial outcomes, thereby providing comprehensive understanding acupuncture’s role in managing PCI, contributing evidence-based clinical practice, informing decision-making. Electronic searches will be performed 12 databases from inception October 2024 without language restrictions. includes both English (PubMed, Cochrane Library, Web Science, Embase, OVID Scopus), well Chinese (China National Knowledge Infrastructure, Wan-Fang Data, Biomedical Literature Database, Scientific Journal Duxiu Database Clinical Trial Registry Center). Randomized controlled trials on included. Primary outcomes include response rate severity; secondary Traditional Medicine Symptom Scale (TCMSS) adverse event rates. Data synthesis use risk ratios dichotomous data mean differences continuous data. Study selection, extraction, quality assessment conducted independently by 2 reviewers. Methodological eligible studies evaluated following <i>Cochrane Handbook Systematic Reviews Interventions</i> (version 6.3). Meta-analysis with RevMan 5.3. Based rate, severity, TCMSS score, rates, this provide an treatment. present current evidence aiming inform practices decision-making enhance PCI. Furthermore, it identify research gaps suggest areas future investigation. PROSPERO CRD42024499284; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=499284 DERR1-10.2196/69417

Language: Английский

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Understanding the Effects of Respiratory Infections on children from Demographic Factors, Seasonal Patterns, and Post-COVID Pandemic Dynamics

Iranian Journal of Medical Microbiology, Journal Year: 2024, Volume and Issue: 18(5), P. 308 - 318

Published: Nov. 30, 2024

Language: Английский

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