The Interplay of Microbiota, Long COVID, and Musculoskeletal Pain: A Narrative Review DOI Creative Commons
Leila Simorgh, Rozita Hedayati,

Mina Sadat Mirshoja

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(2)

Published: Sept. 1, 2024

Context: Long COVID, a condition that persists after the acute phase of COVID-19, poses significant burden, with 10 - 45% recovered patients experiencing persistent symptoms. Among these, approximately 46% report musculoskeletal pain. This narrative review explores potential connections between gut microbiota, and pain, aiming to introduce new therapeutic avenues preventive strategies for managing symptoms in COVID patients. Evidence Acquisition: A comprehensive search was conducted using Google Scholar, Lens.org, ConnectedPaper.com identify relevant articles published 2019 2024. Keywords related pain were used. Articles selected based on predefined inclusion exclusion criteria, their quality assessed. Data from synthesized provide an overview interplay Results: Recent research highlights role microbiota modulating immune responses systemic inflammation. Dysbiosis has been linked severity progression COVID-19 persistence Individuals often experience new-onset manifestations, such as joint myalgia, chronic Additionally, dysbiosis associated conditions like lower back knee osteoarthritis. suggests relationship problems general may also extend patients, indicating broader implications outcomes. Therapeutic targeting probiotics, prebiotics, dietary interventions, have shown promise these improving overall health Conclusions: The evidence underscores importance understanding microbiota-musculoskeletal nexus COVID. Gut contributes inflammation, exacerbating associations other emphasize need microbiota-targeted strategies. Future should focus elucidating mechanisms linking exploring gut-brain axis, developing personalized approaches modulate microbiota. Advancing our this can pave way innovative address complex challenges posed by conditions.

Language: Английский

Cytokine Storm in COVID-19: Exploring IL-6 Signaling and Cytokine-Microbiome Interactions as Emerging Therapeutic Approaches DOI Open Access
Tudorița Gabriela Părângă, Ivona Mitu, Mariana Pavel

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11411 - 11411

Published: Oct. 24, 2024

IL-6 remains a key molecule of the cytokine storms characterizing COVID-19, exerting both proinflammatory and anti-inflammatory effects. Emerging research underscores significance trans-signaling over classical signaling pathways, which has shifted focus therapeutic strategies. Additionally, synergistic action TNF-α IFN-γ been found to induce inflammatory cell death through PANoptosis, further amplifying severity storms. Long COVID-19 patients, as well those with triggered by other conditions, exhibit distinct laboratory profiles, indicating need for targeted approaches diagnosis management. Growing evidence also highlights gut microbiota's crucial role in modulating immune response during affecting production, adding complexity disease's immunological landscape. Targeted intervention strategies should on specific cutoffs, though accurate quantification clinical challenge. Current treatment are increasingly focused inhibiting trans-signaling, offers promise more precise manage hyperinflammatory responses COVID-19. In light recent discoveries, this review summarizes findings storms, particularly their conditions. It explores emerging targeting cytokines like IL-6, TNF-α, IFN-γ, while addressing open questions, such better biomarkers detect ongoing challenges developing treatments that mitigate hyperinflammation without compromising function, emphasizing importance continued field.

Language: Английский

Citations

7
Immunomodulation in Non-traditional Therapies for Methicillin-resistant Staphylococcus aureus (MRSA) Management DOI

Suthi Subbarayudu,

S. Karthick Raja Namasivayam,

Jesu Arockiaraj

et al.

Current Microbiology, Journal Year: 2024, Volume and Issue: 81(10)

Published: Sept. 6, 2024

Language: Английский

Citations

4
Exploring the Potential of Dietary Supplements to Alleviate Pain Due to Long COVID DOI Open Access
Nicoletta Marchesi, Massimo Allegri, Giacomo Matteo Bruno

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1287 - 1287

Published: April 7, 2025

Long COVID, characterized by persistent symptoms following COVID-19 infection, significantly impacts individuals' health and daily functioning due to fatigue pain. Focusing on pain, this review addresses nociplastic chronic pain conditions. Interventions designed reduce inflammation, oxidative stress, enhance vagal activity may offer a promising approach managing post-pandemic This presents individual components of food supplements with demonstrated efficacy in one or more conditions, focusing their proposed mechanisms clinical including use post-COVID-19 when available. Many these substances have long history safe an alternative long-term analgesic drug treatment, which is often associated potential side effects. also explores the for synergistic effects combining each other conventional analgesics, considering advantages both patients healthcare system using as adjunctive primary therapies related COVID. While preclinical scientific literature provides mechanistic basis action several control signaling pathways, experience, particularly field COVID-associated still limited. However, reviewed strongly suggests that attainable goal, provided rigorous trials are conducted.

Language: Английский

Citations

0
The Prevention of Viral Infections: The Role of Intestinal Microbiota and Nutritional Factors DOI Open Access
Annamaria Altomare, Marta Giovanetti,

Francesca Baldaro

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2445 - 2445

Published: July 27, 2024

Viral infections pose significant global challenges due to their rapid transmissibility. Therefore, preventing and treating these promptly is crucial curbing spread. This review focuses on the vital link between nutrition viral infections, underscoring how dietary factors influence immune system modulation. Malnutrition, characterized by deficiencies in essential nutrients such as vitamins A, C, D, E, zinc, can impair system, thereby increasing vulnerability potentially leading more severe health outcomes that complicate recovery. Additionally, emerging evidence highlights role of commensal microbiota regulation, which affect hosts’ susceptibility infections. Specific components, including bioactive compounds, vitamins, probiotics, beneficially modify gut microbiota, thus enhancing response offering protection against aims elucidate mechanisms adjustments impact pathogenesis with a particular focus strengthening system.

Language: Английский

Citations

3
The Interplay of Microbiota, Long COVID, and Musculoskeletal Pain: A Narrative Review DOI Creative Commons
Leila Simorgh, Rozita Hedayati,

Mina Sadat Mirshoja

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(2)

Published: Sept. 1, 2024

Context: Long COVID, a condition that persists after the acute phase of COVID-19, poses significant burden, with 10 - 45% recovered patients experiencing persistent symptoms. Among these, approximately 46% report musculoskeletal pain. This narrative review explores potential connections between gut microbiota, and pain, aiming to introduce new therapeutic avenues preventive strategies for managing symptoms in COVID patients. Evidence Acquisition: A comprehensive search was conducted using Google Scholar, Lens.org, ConnectedPaper.com identify relevant articles published 2019 2024. Keywords related pain were used. Articles selected based on predefined inclusion exclusion criteria, their quality assessed. Data from synthesized provide an overview interplay Results: Recent research highlights role microbiota modulating immune responses systemic inflammation. Dysbiosis has been linked severity progression COVID-19 persistence Individuals often experience new-onset manifestations, such as joint myalgia, chronic Additionally, dysbiosis associated conditions like lower back knee osteoarthritis. suggests relationship problems general may also extend patients, indicating broader implications outcomes. Therapeutic targeting probiotics, prebiotics, dietary interventions, have shown promise these improving overall health Conclusions: The evidence underscores importance understanding microbiota-musculoskeletal nexus COVID. Gut contributes inflammation, exacerbating associations other emphasize need microbiota-targeted strategies. Future should focus elucidating mechanisms linking exploring gut-brain axis, developing personalized approaches modulate microbiota. Advancing our this can pave way innovative address complex challenges posed by conditions.

Language: Английский

Citations

1