Electromagnetic waves destabilize the SARS-CoV-2 Spike protein and reduce SARS-CoV-2 Virus-Like Particle (SC2-VLP) infectivity DOI Creative Commons

Skyler Granatir,

Francisco M. Acosta, Christina Pantoja

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Infection and transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to pose a global public health concern. Using electromagnetic waves represents an alternative strategy inactivate pathogenic viruses such as SARS-CoV-2 reduce overall transmission. However, whether infectivity is unclear. Here, we adapted coplanar waveguide (CPW) identify that could neutralize virus-like particles (SC2-VLPs). Treatment SC2-VLPs, particularly at frequencies between 2.5-3.5 GHz electric field 400 V/m for minutes, reduced infectivity. Exposure frequency 3.1 decreased the binding SC2-VLPs antibodies directed against Spike S1 subunit receptor domain (RBD). These results suggest alter conformation Spike, thereby reducing viral attachment host cell receptors. Overall, this data provides proof-of-concept in using sanitation prevention efforts curb potentially other enveloped viruses.

Language: Английский

Electromagnetic waves destabilize the SARS-CoV-2 Spike protein and reduce SARS-CoV-2 Virus-Like Particle (SC2-VLP) infectivity DOI Creative Commons

Skyler Granatir,

Francisco M. Acosta, Christina Pantoja

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Infection and transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to pose a global public health concern. Using electromagnetic waves represents an alternative strategy inactivate pathogenic viruses such as SARS-CoV-2 reduce overall transmission. However, whether infectivity is unclear. Here, we adapted coplanar waveguide (CPW) identify that could neutralize virus-like particles (SC2-VLPs). Treatment SC2-VLPs, particularly at frequencies between 2.5-3.5 GHz electric field 400 V/m for minutes, reduced infectivity. Exposure frequency 3.1 decreased the binding SC2-VLPs antibodies directed against Spike S1 subunit receptor domain (RBD). These results suggest alter conformation Spike, thereby reducing viral attachment host cell receptors. Overall, this data provides proof-of-concept in using sanitation prevention efforts curb potentially other enveloped viruses.

Language: Английский

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