Phage-specific antibodies: are they a hurdle for the success of phage therapy?

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Phage therapy has attracted attention again owing to the increasing number of drug-resistant bacteria. Although efficacy phage been reported, numerous studies have indicated that generation phage-specific antibodies resulting from administration might an impact on clinical outcomes. Phage-specific promote uptake by macrophages and contribute their rapid clearance body. In addition, neutralizing bind phages diminish antibacterial activity. Thus, antibody production its role in analyzed both vitro vivo. Strategies for prolonging blood circulation time also investigated. However, despite these efforts, results trials are still inconsistent, a consensus whether influence outcomes not yet reached. this review, we summarize during therapy. introduce recently performed discuss affect what can do further improve regimens.

Language: Английский

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Skin-penetrating peptides (SKPs): Enhancing skin permeation for transdermal delivery of pharmaceuticals and cosmetic compounds

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125339 - 125339

Published: Feb. 1, 2025

Language: Английский

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Phage display screening in breast cancer: From peptide discovery to clinical applications

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123077 - 123077

Published: Sept. 1, 2024

Language: Английский

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Living Bacteriophage Engineering for Functional Material Synthesis, Bioanalytical Sensing and Disease Theranostics

Targets, Journal Year: 2024, Volume and Issue: 2(3), P. 157 - 185

Published: July 8, 2024

Facing the increasingly global crisis of antibiotic resistance, it is urgent to develop new antibacterial agents and methods. Simultaneously, as research progresses, occurrence, development, treatment diseases, especially some malignant cancers, are found be closely associated with bacterial microenvironment, prompting us reconsider efficiency existing strategies for disease treatments. Bacteriophages have been employed an extended period owing their high biocompatibility particular targetability toward host strains. Nonetheless, they almost neglected due slow limited efficacy in practice, acute severe infectious cases. In recent years, fantastic advancements various biochemical technologies, such bacteriophage display technology, genetic engineering, chemical molecular enabled scientists conduct a broader range modifications transformations on bacteriophages inherited unique characteristics themselves. As result, series novel platforms designed fabricated significantly enhanced properties multiplied functionalities. These offer avenues combating infections caused by drug-resistant bacteria malignancies that infections, holding great significance potential innovative theranostic applications.

Language: Английский

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Phage Display in Cancer Research: Special Issue Editorial

Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 968 - 968

Published: June 17, 2024

Soon after its birth in 1985, following a short lag period [...]

Language: Английский

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