COVID-19 Pandemic Impacts on STRESS, PTSD, and Prefrontal Cortical Thickness in Pre-Pandemic Trauma Survivors

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 127 - 127

Published: March 26, 2025

Background/Objectives: The COVID-19 pandemic increased psychiatric symptoms in patients with pre-pandemic mental health conditions. However, the effects of on brain, stress, and illness remain largely conjectural. Our objective was to examine how affected prefrontal cortical thicknesses (CTs), PTSD people trauma histories. Methods: Fifty-one survivors from a study who had completed Checklist-5 (PCL) assess sMRI scan measure CTs were re-recruited after pandemic. They subsequently COVID Stress Scale (CSS) Clinician Administered Scale-5 (CAPS) diagnose PTSD, second scan. infection self-reported. Associations between stress symptom assessments post-pandemic CTs, differences vs. non-PTSD groups, changes pre- examined. Results: Pre-pandemic PCL scores positively associated CSS which, turn, higher group. Thicker IFG-opercularis infection. Post-pandemic rMFG IFG-orbitalis CAPS scores. rACC negatively Pre- frontal pole thickened group but thinned group, whereas Conclusions: These findings provide novel evidence that diverse involving cortex structure, subjects history suggest treatments are needed counter these effects.

Language: Английский

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Assessing the Impact of the COVID-19 Pandemic on Childhood Arterial Ischemic Stroke: An Unanticipated Natural Experiment

Stroke, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

BACKGROUND: The VIPS (Vascular Effects of Infection in Pediatric Stroke) II prospective cohort study aimed to better understand published findings that common acute infections, particularly respiratory viruses, can trigger childhood arterial ischemic stroke (AIS). COVID-19 pandemic developed midway through enrollment, creating an opportunity assess its impact. METHODS: Twenty-two sites (North America, Australia) prospectively enrolled 205 children (aged 28 days 18 years) with AIS from December 2016 January 2022, including 100 cases during the epoch, defined here as 2020 2022. To background rates subclinical infection, we stroke-free well children, 39 pandemic. We measured serum SARS-CoV-2 nucleocapsid total antibodies (present after not vaccination; half-life 3–6 months). assessed clinical infection via parental interview. RESULTS: monthly rate eligible declined spring fall 2020, recovering early 2021 and peaking spring. prepandemic were similar except had fewer infections prior month (17% versus 30%; P =0.02) more focal cerebral arteriopathy (20% 11%; =0.09). Among cases, 26 (26%) positive antibodies, 4 (10%) pandemic-era ( =0.04). first case occurred July 2020. Ten (38%) a recent by report, 7 those 10 received diagnosis COVID-19. Only 1 multisystem inflammatory syndrome children. Median (interquartile range) IgG levels 50.1 S/CO (specimen calibrator absorbance ratio; 26.9–95.3) 18.8 (12.0–101) =0.33). CONCLUSIONS: may have dual effects on AIS: indirect protective effect related public health measures reducing infectious exposure general, deleterious emerged another virus AIS.

Language: Английский

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Internal medicine at the crossroads of long COVID diagnosis and management

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 2, 2025

The lack of specificity in its definition is a major obstacle to both explanatory and therapeutic research long COVID. It brings together, on the one hand, patients with severe COVID-19 who suffer classic complications prolonged hospitalization decompensation comorbidities and, other non-severe acute report multiple symptoms that cannot be fully explained by biomechanical model. Indeed, despite numerous studies, it remains unclear how persistent viral infection, immunological or coagulation disturbances may contribute mechanistically Nevertheless, internal medicine should good place manage these patients. diversity evoke broad spectrum differential diagnoses are familiar internists. Their experience exploration unexplained also valuable. can reduce need for consultations specialists unnecessary laboratory imaging tests. However, COVID diagnosis limited exclusion all conditions one. An open non-dualistic approach required identify mechanisms explain symptoms. Based their clinical experience, most French internists responded an opinion survey consider corresponds closely functional somatic disorder (FSD) seek help mental health care assist management multi-disciplinary approach. as FSDs, usually reluctant managed specialists, given very physical nature presentation. Unfortunately, physicians turn take them, due poor knowledge about FSD, leading failure. Alternatively, comprehensive multidisciplinary orchestrated experienced internist generally well-accepted. includes providing rational cognitive explanations support behavioral changes tailored patient. While waiting hypothetical randomized controlled trials assessing drugs positive results, such holistic has been successfully applied many individuals generalization would require much broader training FSD providers.

Language: Английский

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Effect of autaptic synapse on signal transmission performance of dressed Hodgkin–Huxley neuron

Chaos Solitons & Fractals, Journal Year: 2024, Volume and Issue: 188, P. 115579 - 115579

Published: Oct. 1, 2024

Language: Английский

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