Molecular Medicine Reports,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Nov. 7, 2024
Procollagen‑lysine,
2‑oxoglutarate
5‑dioxygenase
2
(PLOD2)
has
been
identified
as
an
oncogene
involved
in
the
progression
of
several
human
cancers.
However,
its
role
cervical
squamous
cell
carcinoma
(CESC)
and
underlying
mechanisms
are
not
well
understood.
In
present
study,
public
databases,
RT‑qPCR
western
blotting
were
employed
to
detect
expression
PLOD2
prognosis
CESC.
Cell
counting
kit‑8
assay,
wound
healing
Transwell
flow
cytometry
utilized
assess
proliferation,
migration
apoptosis
CESC
cells.
Cellular
senescence
was
examined
by
β‑galactosidase
staining.
Prediction
binding
Yes‑associated
protein
1
(YAP1)
assessed
using
BioGrid,
HDock
co‑immunoprecipitation,
p53
p21
signaling
immunofluorescence
The
findings
indicated
that
elevated
tissues
lines,
silencing
caused
inhibition
promotion
predicted
be
bound
YAP1
overexpression
reversed
effects
on
migration,
senescence.
addition,
facilitated
regulating
P53
pathway
through
YAP1.
exerted
pro‑oncogenic
These
provide
new
perspectives
for
future
study
PLOD2‑targeted
therapy
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
unknown, P. 120 - 122
Published: July 31, 2024
Paciente
femenina
de
55
años,
con
antecedentes
personales
patológicos
hipotiroidismo,
artritis
reumatoide
tratada
metotrexato
y
corticoides
orales,
displasia
cervical
(VPH)
hace
5
años
e
historia
ansiedad.
Acude
a
la
consulta
dermatológica
por
lesiones
aspecto
verrucoso,
crecimiento
progresivo,
2
evolución
en
el
borde
lateral
ambos
talones
región
periungueal
del
dedo
medio
mano
izquierda.
La
paciente
refiere
que
las
son
asintomáticas,
pero
exagerado
mismas.
Virology Journal,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Oct. 7, 2024
Human
papillomavirus
(HPV),
is
one
of
the
main
causes
cervical
cancer
and
also
most
common
sexually
transmitted
infections
(STIs).
HPV
responsible
for
almost
all
cases
plays
a
principal
role
in
causing
other
cancers
including
oropharynx,
penis,
larynx,
oral
cavity,
anus,
vulva,
vagina.
The
study
aims
to
investigate
prevalence
distribution
genotypes
among
patients
referred
private
laboratories
Mashhad,
located
northeast
Iran.
BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Nov. 1, 2024
Diet
may
influence
susceptibility
of
human
papillomavirus
(HPV)
infection
by
affecting
inflammation
and
immunity.
However,
the
association
between
HPV
inflammatory
potential
diet
has
not
been
investigated.
The
research
aimed
to
examine
correlation
status
dietary
index
(DII
Molecular Medicine Reports,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Nov. 7, 2024
Procollagen‑lysine,
2‑oxoglutarate
5‑dioxygenase
2
(PLOD2)
has
been
identified
as
an
oncogene
involved
in
the
progression
of
several
human
cancers.
However,
its
role
cervical
squamous
cell
carcinoma
(CESC)
and
underlying
mechanisms
are
not
well
understood.
In
present
study,
public
databases,
RT‑qPCR
western
blotting
were
employed
to
detect
expression
PLOD2
prognosis
CESC.
Cell
counting
kit‑8
assay,
wound
healing
Transwell
flow
cytometry
utilized
assess
proliferation,
migration
apoptosis
CESC
cells.
Cellular
senescence
was
examined
by
β‑galactosidase
staining.
Prediction
binding
Yes‑associated
protein
1
(YAP1)
assessed
using
BioGrid,
HDock
co‑immunoprecipitation,
p53
p21
signaling
immunofluorescence
The
findings
indicated
that
elevated
tissues
lines,
silencing
caused
inhibition
promotion
predicted
be
bound
YAP1
overexpression
reversed
effects
on
migration,
senescence.
addition,
facilitated
regulating
P53
pathway
through
YAP1.
exerted
pro‑oncogenic
These
provide
new
perspectives
for
future
study
PLOD2‑targeted
therapy
