Molecular and In Vivo Characterization of the High Pathogenicity H7N6 Avian Influenza Virus That Emerged in South African Poultry in 2023 DOI Creative Commons
Célia Abolnik, Thandeka Phiri, Christine Strydom

et al.

Transboundary and Emerging Diseases, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

A high pathogenicity avian influenza (HPAI) subtype H7N6 virus emerged in South African poultry 2023 and later spread to Mozambique, the first documented emergence of H7 HPAI continent. total 6.82 million birds succumbed disease or were culled, representing about 20% egg‐laying flock almost 30% broiler breeder flock. The complete genomes 68 outbreak viruses sequenced analyzed, tracing phylogenetic origins ancestral a reassortment various subtypes that circulated southern wild birds. Molecular clock analysis determined week May 2023, probably smallholder chicken flock, before spreading commercial farms, where was reported early June. multibasic hemagglutinin protein cleavage site (HA 0 ) derived from nonhomologous recombination event with 28S ribosomal ribonucleic acid (RNA). Few genetic markers associated an increased risk humans present translated viral proteins. intravenous index (IVPI) value case isolate 1.67, reflecting 50% specific pathogen‐free chickens died within 4 days infection. Surviving showing mostly mild clinical signs recovered by day 10 postinfection. Prior death, shed primarily through respiratory route, lower amounts cloaca, but survivors, still being cloaca on 10. Fomites likely source between amount per gram feces calculated at ~383,193 (5.58 log egg infectious dose 50 (EID equivalents, feather follicles contained average 739,712.43 (5.87 EID 20 µg dust 14,976.96 (4.175 equivalents.

Language: Английский

Molecular and In Vivo Characterization of the High Pathogenicity H7N6 Avian Influenza Virus That Emerged in South African Poultry in 2023 DOI Creative Commons
Célia Abolnik, Thandeka Phiri, Christine Strydom

et al.

Transboundary and Emerging Diseases, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

A high pathogenicity avian influenza (HPAI) subtype H7N6 virus emerged in South African poultry 2023 and later spread to Mozambique, the first documented emergence of H7 HPAI continent. total 6.82 million birds succumbed disease or were culled, representing about 20% egg‐laying flock almost 30% broiler breeder flock. The complete genomes 68 outbreak viruses sequenced analyzed, tracing phylogenetic origins ancestral a reassortment various subtypes that circulated southern wild birds. Molecular clock analysis determined week May 2023, probably smallholder chicken flock, before spreading commercial farms, where was reported early June. multibasic hemagglutinin protein cleavage site (HA 0 ) derived from nonhomologous recombination event with 28S ribosomal ribonucleic acid (RNA). Few genetic markers associated an increased risk humans present translated viral proteins. intravenous index (IVPI) value case isolate 1.67, reflecting 50% specific pathogen‐free chickens died within 4 days infection. Surviving showing mostly mild clinical signs recovered by day 10 postinfection. Prior death, shed primarily through respiratory route, lower amounts cloaca, but survivors, still being cloaca on 10. Fomites likely source between amount per gram feces calculated at ~383,193 (5.58 log egg infectious dose 50 (EID equivalents, feather follicles contained average 739,712.43 (5.87 EID 20 µg dust 14,976.96 (4.175 equivalents.

Language: Английский

Citations

0