Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals DOI Creative Commons
Yuanqing Wang, Xiaojie Jiang, Xi Yuan

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

The family Circoviridae includes the genera Circovirus and Cyclovirus. Cycloviruses have been found in serum samples from chronic HBV, HCV, or HIV-infected individuals as well asymptomatic blood donors. However, research on cycloviruses is relatively limited. We used viral metagenomics to mine, analyze, visualize human virome, successfully identifying three new genomes, each encoding Rep Capsid proteins. These proteins are crucial for replication host-cell interaction: protein involved initiating genome replication, while plays a key role assembly of virions virus's ability interact with host immune systems. Distance matrix phylogenetic analyses show that these share high sequence similarity viruses both humans animals across different regions Africa. This finding not only confirms presence previously uncharacterized blood, but also provides insight into their potential transmission ecological significance. Further needed explore functional roles pathogenesis, particularly how they may influence immunity contribute infections. Additionally, studies investigating range mechanisms cross-species will be essential understanding broader implications animal health.

Language: Английский

Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals DOI Creative Commons
Yuanqing Wang, Xiaojie Jiang, Xi Yuan

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

The family Circoviridae includes the genera Circovirus and Cyclovirus. Cycloviruses have been found in serum samples from chronic HBV, HCV, or HIV-infected individuals as well asymptomatic blood donors. However, research on cycloviruses is relatively limited. We used viral metagenomics to mine, analyze, visualize human virome, successfully identifying three new genomes, each encoding Rep Capsid proteins. These proteins are crucial for replication host-cell interaction: protein involved initiating genome replication, while plays a key role assembly of virions virus's ability interact with host immune systems. Distance matrix phylogenetic analyses show that these share high sequence similarity viruses both humans animals across different regions Africa. This finding not only confirms presence previously uncharacterized blood, but also provides insight into their potential transmission ecological significance. Further needed explore functional roles pathogenesis, particularly how they may influence immunity contribute infections. Additionally, studies investigating range mechanisms cross-species will be essential understanding broader implications animal health.

Language: Английский

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