Power of Memory: A Natural Killer Cell Perspective DOI Creative Commons

Oishi Sinha,

SK Abhipsha,

Sumit Sen Santara

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(11), P. 846 - 846

Published: June 5, 2025

Memory is an incredible aspect of our immune system. Similarly to cognitive memory, it allows us remember and respond more efficiently subsequent encounters with the same pathogens, making possible act on information built by previous experiences. This process critical for body’s defenses against infections cornerstone effectiveness vaccines. Immunological traditionally considered exclusive quality adaptive system, a sophisticated component response system that characterized ability recognize specific pathogens. form memory primarily observed in antigen-specific T B cells, which are specialized recognizing particular antigens generating quicker upon each successive reinfection over long period time. Natural killer (NK) essential as first line defense wide range viral tumors, have been classified key innate their lack antigen specificity memory. However, concept vs. has evolving, increasing evidence suggesting cellular subsets may also play role immunological review aims provide comprehensive overview recent advances understandings molecular mechanisms driving development memory-like properties NK primary focus human data context various diseases infectious conditions. Additionally, we will examine therapeutic implications these findings, highlighting how insights into cell can contribute novel immunotherapies improve strategies treating infections, cancer, autoimmune disorders.

Language: Английский

Immuno-cell metabolic changes in HIV-1 infection DOI Creative Commons
Xu Li, Yue Jiang, Xuexing Zheng

et al.

Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Recent research has shown that metabolic processes within immune cells are essential for both human immunodeficiency virus 1 (HIV-1) infection and the response. Throughout HIV-1 infection—from acute stages to chronic viral latency—immune experience shifts in energy demands pathways, paralleling T-cell exhaustion. Dysregulated metabolism compromises cell function, leading dysfunction persistent inflammation. Therefore, alterations constitute a critical mechanism progression This review specifically explores profiles roles of T cells, monocytes-macrophages, dendritic natural killer B at different infection, emphasizing effects on pathways diverse types. These insights offer valuable therapeutic strategies aimed inhibiting replication, restoring controlling disease progression.

Language: Английский

Citations

0
Power of Memory: A Natural Killer Cell Perspective DOI Creative Commons

Oishi Sinha,

SK Abhipsha,

Sumit Sen Santara

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(11), P. 846 - 846

Published: June 5, 2025

Memory is an incredible aspect of our immune system. Similarly to cognitive memory, it allows us remember and respond more efficiently subsequent encounters with the same pathogens, making possible act on information built by previous experiences. This process critical for body’s defenses against infections cornerstone effectiveness vaccines. Immunological traditionally considered exclusive quality adaptive system, a sophisticated component response system that characterized ability recognize specific pathogens. form memory primarily observed in antigen-specific T B cells, which are specialized recognizing particular antigens generating quicker upon each successive reinfection over long period time. Natural killer (NK) essential as first line defense wide range viral tumors, have been classified key innate their lack antigen specificity memory. However, concept vs. has evolving, increasing evidence suggesting cellular subsets may also play role immunological review aims provide comprehensive overview recent advances understandings molecular mechanisms driving development memory-like properties NK primary focus human data context various diseases infectious conditions. Additionally, we will examine therapeutic implications these findings, highlighting how insights into cell can contribute novel immunotherapies improve strategies treating infections, cancer, autoimmune disorders.

Language: Английский

Citations

0