bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 20, 2023
Abstract
Virotherapy
treatment
is
a
new
and
promising
target
therapy
that
selectively
attacks
cancer
cells
without
harming
normal
cells.
Mathematical
models
of
oncolytic
viruses
have
shown
predator-prey
like
oscillatory
patterns
as
result
an
underlying
Hopf
bifurcation.
In
spatial
context,
these
oscillations
can
lead
to
different
spatio-temporal
phenomena
such
hollow-ring
patterns,
dispersed
patterns.
this
paper
we
continue
the
systematic
analysis
discuss
their
relevance
in
clinical
context.
We
consider
bifurcation
spatially
explicit
reaction-diffusion
model
find
above
mentioned
virus
infection
The
desired
pattern
for
tumor
eradication
hollow
ring
exact
conditions
its
occurrence.
Moreover,
derive
minimal
speed
travelling
invasion
waves
virus.
Our
numerical
simulations
2-D
reveal
complex
interactions
phenomenon
periodic
peak
splitting.
An
effect
cannot
explain
with
our
current
methods.
PLoS ONE,
Journal Year:
2021,
Volume and Issue:
16(10), P. e0257975 - e0257975
Published: Oct. 12, 2021
In
this
paper,
a
new
mathematical
model
is
formulated
that
describes
the
interaction
between
uninfected
cells,
infected
viruses,
intracellular
viral
RNA,
Cytotoxic
T-lymphocytes
(CTLs),
and
antibodies.
Hence,
contains
certain
biological
relations
are
thought
to
be
key
factors
driving
which
allow
us
obtain
precise
logical
conclusions.
Therefore,
it
improves
our
perception,
would
otherwise
not
possible,
comprehend
pathogenesis,
interpret
clinical
data,
control
treatment,
suggest
relations.
This
can
used
study
dynamics
in
patients
for
wide
range
of
infectious
diseases
like
HIV,
HPV,
HBV,
HCV,
Covid-19.
Though,
analysis
multiscale
HCV
incorporating
immune
system
response
considered
detail,
results
applied
all
other
viruses.
The
utilizes
transformed
form
ordinary
differential
equations
(ODE)
incorporates
into
system.
role
CTLs
antibody
responses
investigated.
positivity
solutions
proven,
basic
reproduction
number
obtained,
equilibrium
points
specified.
stability
at
analyzed
based
on
Lyapunov
invariance
principle.
By
using
appropriate
functions,
point
proven
globally
asymptotically
stable
when
less
than
one
unstable
otherwise.
Global
considered,
has
been
found
each
specific
domain
stability.
Stability
regions
could
overlapped
bistable
equilibria
found,
means
coexistence
two
points.
solution
converges
them
depending
initial
conditions.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: July 23, 2021
V937
is
an
investigational
novel
oncolytic
non-genetically
modified
Kuykendall
strain
of
Coxsackievirus
A21
which
in
clinical
development
for
the
treatment
advanced
solid
tumor
malignancies.
infects
and
lyses
cells
expressing
intercellular
adhesion
molecule
I
(ICAM-I)
receptor.
We
integrated
vitro
vivo
data
from
six
different
preclinical
studies
to
build
a
mechanistic
model
that
allowed
quantitative
analysis
biological
processes
viral
kinetics
dynamics,
distribution
tumor,
anti-tumor
response
elicited
by
human
xenograft
models
immunodeficient
mice
following
intratumoral
intravenous
administration.
Estimates
infection
replication
were
calculated
experiments
successfully
used
describe
under
various
experimental
conditions.
Despite
predicted
high
clearance
rate
systemic
circulation
(t
1/2
=
4.3
min),
was
observed
resulted
shrinkage
with
both
The
described
framework
represents
step
towards
characterization
distribution,
replication,
effect
virus
administrations
absence
immune
response.
This
may
further
be
expanded
integrate
role
system
on
dynamics
support
viruses.
ImmunoInformatics,
Journal Year:
2022,
Volume and Issue:
6, P. 100011 - 100011
Published: March 2, 2022
Combined
oncolytic
virotherapy
and
immunotherapy
(immunovirotherapy)
protocols
represent
a
promising
treatment
strategy
for
range
of
cancers
offer
many
advantages
over
conventional
anti-cancer
therapies.
Nevertheless,
there
are
considerable
challenges
this
therapeutic
modality,
clinical
failures
remain
prevalent.
Determining
which
combination
regimens
to
investigate
given
the
burgeoning
number
derivatives
remains
tremendous
challenge
field.
Fortunately,
mathematical
modelling
is
well
placed
assist
in
identifying
optimal
improving
these
treatments.
However,
translation
predictions
actionable
changes
severely
lacking.
Here,
two
mathematicians
experimentalists
discuss
their
respective
viewpoints
concerning
current
state
immunovirotherapy,
facing
field
how
contributions
from
experimental
research
can
be
better
integrated
future.
By
initiating
dialogue,
we
arrive
at
conclusion
that
translational
process
improved
by
first
conducting
extensive
investigations
using
relevant
data
before
proceeding
pre-clinical
finally
trials.
exploiting
approaches
such
as
virtual
trials,
may
able
limit
combinations
should
tested
clinically.
Overall,
integration
efforts
modellers
insufficient
support
major
advances
field,
it
only
with
cross-disciplinary
immunovirotherapy
robustly
effective
cancer
treatment.
International Journal of Modelling and Simulation,
Journal Year:
2023,
Volume and Issue:
45(1), P. 364 - 385
Published: May 3, 2023
This
work
investigates
the
synergistic
effects
of
combination
oncolytic
virotherapy
and
chemotherapy
on
tumour
cells.
A
mathematical
model,
in
form
ordinary
differential
equations,
is
developed,
analysed
numerically
simulated.
Analytical
results
show
that
without
treatment,
a
would
grow
to
its
maximum
size.
Also,
presence
microenvironment,
their
own
are
incapable
clearing
cells
but
instead
reduce
concentration.
However,
with
use
chemovirotherapy
all
depleted.
It
also
demonstrated
as
virus
burst
size
infection
rate
increased,
many
infected
produced
make
them
more
susceptible
chemotherapeutic
drug.
Furthermore,
successful
therapy
depends
size,
rate,
drug-infusion
method.
Numerical
simulations
affirm
highly
effective
combating
cancer
which
agreement
some
recent
theoretical
experimental
studies.
Journal of Biological Dynamics,
Journal Year:
2019,
Volume and Issue:
13(1), P. 733 - 748
Published: Jan. 1, 2019
In
this
paper,
we
consider
a
system
of
delay
differential
equations
that
models
the
oncolytic
virotherapy
on
solid
tumours
with
viral
infection
in
presence
innate
immune
response.
We
conduct
qualitative
and
numerical
analysis,
provide
possible
medical
implications
for
our
results.
The
has
four
equilibrium
solutions.
Fixed
point
analysis
indicates
increasing
burst
size
rate
viruses
positive
contribution
to
therapy.
However,
killing
rate,
stimulation
or
virus
may
lead
treatment
failed.
time
induces
backward
Hopf
bifurcations,
which
means
therapy
fail
before
increases
passing
through
bifurcation.
parameter
also
shows
how
saddle-node
bifurcations
occur
as
other
parameters
vary,
yields
further
insights
into
dynamics
virotherapy.
After
decades
of
research,
oncolytic
virotherapy
has
recently
advanced
to
clinical
application,
and
currently
a
multitude
novel
agents
combination
treatments
are
being
evaluated
for
cancer
therapy.
Oncolytic
preferentially
replicate
in
tumor
cells,
inducing
cell
lysis
complex
anti-tumor
effects,
such
as
innate
adaptive
immune
responses
the
destruction
vasculature.
With
availability
different
vector
platforms
potential
both
genetic
engineering
regimens
enhance
particular
aspects
safety
efficacy,
identification
optimal
patient
subpopulations
or
even
individual
patients
becomes
top
priority.
Mathematical
modeling
can
provide
support
this
arena
by
making
use
experimental
data
generate
hypotheses
about
mechanisms
underlying
biology
and,
ultimately,
predict
treatment
protocols.
Increasingly
models
be
applied
account
therapeutically
relevant
parameters
components
system.
In
review,
we
describe
current
developments
mathematical
discuss
benefit
integrating
approaches
into
biological
experimentation.
Conclusively,
propose
mutual
these
fields
research
more
efficient
development
effective
treatments.
