Durability of the Effectiveness of Heterologous COVID-19 Vaccine Regimens in Thailand: Retrospective Cohort Study Using National Registration Data (Preprint) DOI
Ponlagrit Kumwichar, Chittawan Poonsiri, Siobhan Botwright

et al.

Published: April 17, 2023

BACKGROUND The durability of heterologous COVID-19 vaccine effectiveness (VE) has been primarily studied in high-income countries, while evaluation policies low- and middle-income countries remains limited. OBJECTIVE We aimed to evaluate the duration during which VE regimens mitigating serious outcomes, specifically severe death following hospitalization with COVID-19, over 50%. METHODS formed a dynamic cohort by linking records Thai citizens aged ≥18 years from citizen vital, vaccine, cases registry databases between May 2021 July 2022. Encrypted identification numbers were used merge data databases. This study focuses on 8 common sequences: CoronaVac/ChAdOx1, ChAdOx1/BNT162b2, CoronaVac/CoronaVac/ChAdOx1, CoronaVac/ChAdOx1/ChAdOx1, CoronaVac/ChAdOx1/BNT162b2, BBIBP-CorV/BBIBP-CorV/BNT162b2, ChAdOx1/ChAdOx1/BNT162b2, ChAdOx1/ChAdOx1/mRNA-1273. Nonimmunized individuals considered for comparisons. was stratified according vaccination status, age, sex, province location, month vaccination, outcome. Data analysis employed logistic regression determine VE, accounting potential confounders time, observed follow-up period 7 months. RESULTS includes 52,580,841 individuals, approximately 17,907,215 17,190,975 receiving 2- 3-dose vaccines (not mutually exclusive), respectively. 2-dose vaccinations offered 50% against 2 months; however, protection significantly declined time. sustained both outcomes at least months, as determined time-interaction modeling. sequence consisting CoronaVac/CoronaVac/ChAdOx1 demonstrated >80% no evidence waning. final monthly measured months after last dose 82% (95% CI 80.3%-84%) 86.3% 83.6%-84%), CONCLUSIONS In Thailand, within 7-month observation period, could not maintain fatal but all did. regimen showed best protective effect COVID-19. estimated across supports adoption prime-boost strategies, primary series inactivated virus boosting either viral vector or an mRNA prevent similar pandemics countries.

Language: Английский

Impact of COVID-19 Vaccination in Thailand: Averted Deaths and Severe Infections Across Age Groups DOI Creative Commons
Chaiwat Wilasang, Pikkanet Suttirat, Dhammika Leshan Wannigama

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(12), P. 286 - 286

Published: Nov. 22, 2024

The COVID-19 pandemic has underscored the pivotal role of vaccines in mitigating devastating impact virus. In Thailand, vaccination campaign against SARS-CoV-2 began on 28 February 2021, initially prioritizing healthcare professionals before expanding into a nationwide effort 7 June 2021. This study employs mathematical model transmission with to analyze Thailand's program from 1 March 2021 31 December 2022. We specifically assess potential loss lives and occurrence severe infections across various age groups hypothetical scenario where were not administered. By fitting our officially reported death data, analysis reveals that efforts prevented total 300,234 deaths (95% confidence interval: 295,938-304,349) averted 1.60 million 1.54-1.65 million). Notably, elderly population over 80 years old benefited most vaccination, an estimated 84,518 saved, constituting 4.28% this group. Furthermore, individuals aged between 70 74 experienced highest reduction infections, potentially preventing 8.35% bracket developing COVID-19.

Language: Английский

Citations

0
IMPLEMENTATION OF THE HEALTHY INDONESIA PROGRAM WITH A FAMILY APPROACH (PIS-PK) AT COMMUNITY HEALTH CENTERS IN BINTAN DISTRICT, KEPULAUAN RIAU PROVINCE DOI Creative Commons

Moh Bisri

International Journal of Social Science, Journal Year: 2023, Volume and Issue: 2(6), P. 2423 - 2428

Published: April 20, 2023

One of the policies to strengthen quality essential health efforts is through Healthy Indonesia Program with a Family Approach (PIS-PK), monitoring and evaluating measure whether policy implementation going according expected goals. This study's purpose was implement (PIS-PK) at Bintan District Health Center. study uses qualitative design, determining informants by purposive sampling technique where primary are five people, triangulation six. Data analysis content analysis. The results PIS-PK research could have been more optimal. factors that support communication gone well internal external socialization attitude factor implementer committing enough program's well. While inhibiting in terms resources limited resources, program infrastructure, delays budget disbursement. From bureaucratic structure factor, there needs be tiered coordination between office puskesmas. district can immediately create organizational facilitate coordination, disbursement process provide infrastructure. There cross-sectoral collaboration supporting Center

Language: Английский

Citations

0
Durability of the Effectiveness of Heterologous COVID-19 Vaccine Regimens in Thailand: Retrospective Cohort Study Using National Registration Data (Preprint) DOI
Ponlagrit Kumwichar, Chittawan Poonsiri, Siobhan Botwright

et al.

Published: April 17, 2023

BACKGROUND The durability of heterologous COVID-19 vaccine effectiveness (VE) has been primarily studied in high-income countries, while evaluation policies low- and middle-income countries remains limited. OBJECTIVE We aimed to evaluate the duration during which VE regimens mitigating serious outcomes, specifically severe death following hospitalization with COVID-19, over 50%. METHODS formed a dynamic cohort by linking records Thai citizens aged ≥18 years from citizen vital, vaccine, cases registry databases between May 2021 July 2022. Encrypted identification numbers were used merge data databases. This study focuses on 8 common sequences: CoronaVac/ChAdOx1, ChAdOx1/BNT162b2, CoronaVac/CoronaVac/ChAdOx1, CoronaVac/ChAdOx1/ChAdOx1, CoronaVac/ChAdOx1/BNT162b2, BBIBP-CorV/BBIBP-CorV/BNT162b2, ChAdOx1/ChAdOx1/BNT162b2, ChAdOx1/ChAdOx1/mRNA-1273. Nonimmunized individuals considered for comparisons. was stratified according vaccination status, age, sex, province location, month vaccination, outcome. Data analysis employed logistic regression determine VE, accounting potential confounders time, observed follow-up period 7 months. RESULTS includes 52,580,841 individuals, approximately 17,907,215 17,190,975 receiving 2- 3-dose vaccines (not mutually exclusive), respectively. 2-dose vaccinations offered 50% against 2 months; however, protection significantly declined time. sustained both outcomes at least months, as determined time-interaction modeling. sequence consisting CoronaVac/CoronaVac/ChAdOx1 demonstrated >80% no evidence waning. final monthly measured months after last dose 82% (95% CI 80.3%-84%) 86.3% 83.6%-84%), CONCLUSIONS In Thailand, within 7-month observation period, could not maintain fatal but all did. regimen showed best protective effect COVID-19. estimated across supports adoption prime-boost strategies, primary series inactivated virus boosting either viral vector or an mRNA prevent similar pandemics countries.

Language: Английский

Citations

0