SARS-CoV-2 Antibody Level after Homologous and Heterologous Booster Vaccines: an 18-month Longitudinal Observational Cohort Study in Indonesia DOI Open Access
Tonang Dwi Ardyanto,

Khariri,

Telly Purnamasari Agus

et al.

The Open Public Health Journal, Journal Year: 2024, Volume and Issue: 17(1)

Published: July 31, 2024

Background Recently, there have been reports of the rise COVID-19 cases in several sites. The effectiveness vaccine was reported elsewhere. There are still questions on how kinetics antibody response during relatively long periods, need for additional doses, and effect homologous heterologous boosters. study conducted to analyze after primary dose third ChAdOx1 individuals previously receiving two doses [homologous] CoronaVac [heterologous] vaccines. Methods population comprised 52 men 98 women, divided into Recipients first according recommended schedule by Ministry Health Indonesia [MoH].Six months second dose, administered as a booster. levels were measured CMIA method before [time-point or TP1], weeks [TP2], [TP3], 1 month [TP4], 12 [TP5], 18 [TP6] administration. Six Along with these, epidemiological data collected from subjects TP1. Results A total 153 serum samples who had received measured. On TP1, reactivity [the level >50 AU/mL] detected 100 [66,67%] subjects, indicating possible previous exposure SARS-CoV-2. TP2, sharp increase documented group. However, following cohort, gap narrowing, TP6, showed no significant difference between groups [p>0.05]. Likewise, differences shown without history TP1 Considering characteristics, based sex, age groups, BMI level. Conclusion This provides deeper understanding longitudinally among those SARS CoV-2 infection, recipients different vaccines, It is necessary elucidate further next reflects neutralizing an indicator protection against infection risk.

Language: Английский

SARS-CoV-2 seropositivity amongst healthcare workers in South Africa during the Omicron wave: natural infection versus vaccination DOI
Daniel Hoffmann, Pieter Meyer, Catherine Worsley

et al.

Journal of Clinical Pathology, Journal Year: 2025, Volume and Issue: unknown, P. jcp - 209722

Published: Jan. 16, 2025

Concerns over population-level immunity have been heightened with each successive wave of COVID-19, prompting questions about whether it is primarily derived from vaccination efforts or previous natural infections the virus. We wished to determine seroprevalence SARS-CoV-2 antibodies among healthcare workers (HCWs) in Pretoria (Tshwane), South Africa, and establish they were infection. Serum samples collected HCWs during fourth COVID-19 between 1 December 2021 13 March 2022. The tested using Abbott Spike IgG (S-IgG), IgM (S-IgM) Nucleocapsid (NC-IgG) kits. Of 221 participants, 76% (n=168) women 24% (n=53) men. A total 96.4% (n=213) participants vaccinated. Natural infection-derived detected 23% (n=51) vaccine-derived 74% (n=164) HCWs. Even after three waves most their detectable vaccination. Vaccination remains an essential tool protect patients

Language: Английский

Citations

0
The Effect of Exposure to SARS-CoV-2 Vaccination and Infection on Humoral and Cellular Immunity in a Cohort of Patients with Immune-Mediated Diseases: A Pilot Study DOI Creative Commons
Giulia Costanzo, Giuseppina Sanna, Francesco Pes

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(6), P. 506 - 506

Published: June 14, 2024

Immunization against COVID-19 is needed in patients with immune-mediated inflammatory diseases (IMIDs). However, data on long-term immunity kinetics remain scarce. This study aimed to compare the humoral and cellular response (IMIDs) compared healthy controls. We SARS-Cov-2 elicited by vaccination and/or infection a prospective cohort of 20 IMID group 21 healthcare workers (HCWs). assessed before after third fourth dose BNT162b2 or using quantitative IgG anti-SARS-CoV-2 Spike antibody (anti-S-IgG), neutralization assay, specific interferon-gamma (IFN-g) release assay (IGRA). The responses were those two groups similar age total exposure, becoming infected for first time, mainly dose. Neutralizing antibodies IGRA negative 9.5% but not any HCWs. No significant difference was found between titers BA.1 HCW groups. highlights SARS-CoV-2 immunological controls patients, suggesting that combined stimuli could promote more profound response.

Language: Английский

Citations

1
SARS-CoV-2 Antibody Level after Homologous and Heterologous Booster Vaccines: an 18-month Longitudinal Observational Cohort Study in Indonesia DOI Open Access
Tonang Dwi Ardyanto,

Khariri,

Telly Purnamasari Agus

et al.

The Open Public Health Journal, Journal Year: 2024, Volume and Issue: 17(1)

Published: July 31, 2024

Background Recently, there have been reports of the rise COVID-19 cases in several sites. The effectiveness vaccine was reported elsewhere. There are still questions on how kinetics antibody response during relatively long periods, need for additional doses, and effect homologous heterologous boosters. study conducted to analyze after primary dose third ChAdOx1 individuals previously receiving two doses [homologous] CoronaVac [heterologous] vaccines. Methods population comprised 52 men 98 women, divided into Recipients first according recommended schedule by Ministry Health Indonesia [MoH].Six months second dose, administered as a booster. levels were measured CMIA method before [time-point or TP1], weeks [TP2], [TP3], 1 month [TP4], 12 [TP5], 18 [TP6] administration. Six Along with these, epidemiological data collected from subjects TP1. Results A total 153 serum samples who had received measured. On TP1, reactivity [the level >50 AU/mL] detected 100 [66,67%] subjects, indicating possible previous exposure SARS-CoV-2. TP2, sharp increase documented group. However, following cohort, gap narrowing, TP6, showed no significant difference between groups [p>0.05]. Likewise, differences shown without history TP1 Considering characteristics, based sex, age groups, BMI level. Conclusion This provides deeper understanding longitudinally among those SARS CoV-2 infection, recipients different vaccines, It is necessary elucidate further next reflects neutralizing an indicator protection against infection risk.

Language: Английский

Citations

0