Gut Microbiota Predicts Treatment Response to Empagliflozin Among MASLD Patients Without Diabetes Mellitus
Liver International,
Journal Year:
2025,
Volume and Issue:
45(3)
Published: Feb. 14, 2025
ABSTRACT
Background
and
Aim
We
aimed
to
investigate
whether
gut
microbiota
could
predict
the
treatment
response
pharmacological
agents
among
metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD)
patients
without
diabetes
mellitus
(DM),
as
data
are
lacking.
Methods
prospectively
followed
up
non‐diabetic
MASLD
who
used
empagliflozin.
Clinical,
anthropometric,
laboratory
assessments
magnetic
resonance
imaging‐proton
density
fat
fraction
(MRI‐PDFF)
were
performed
from
baseline
week
52
(EOT).
Baseline
stool
samples
collected,
shotgun
DNA
metagenomic
sequencing
was
profile
microbiome.
The
primary
outcome
empagliflozin
at
EOT,
defined
MRI‐PDFF
decline
≥
30%
EOT
baseline.
Linear
discriminant
analysis
[LDA]
effect
size
identify
putative
bacterial
species.
Multivariable
logistic
regression
derive
adjusted
odds
ratio
(aOR)
of
with
species
by
adjusting
for
clinical
factors.
Results
Twenty‐two
(48.9%)
45
(median
age:
56.9
years
[IQR:
51.0–63.2];
male:
23
[51.1%])
achieved
EOT.
There
difference
in
alpha
diversity
(Shannon
index:
p
<
0.001;
Simpson
=
0.001)
beta
(
0.048)
microbiome
between
non‐response
groups.
Faecalibacterium
prausnitzii
(log
10
LDAscore
4.27),
Lachnospira
pectinoschiza
3.99),
Anaerostipes
hadrus
3.98),
Roseburia
faecis
3.97),
inulinivorans
3.58)
Agathobaculum
butyriciproducens
2.77)
enriched
group.
L.
(aOR:
34.1;
0.015),
A.
(aOR:35.0;
0.032)
(aOR:22.3;
0.023)
independently
predicted
but
not
These
three
collectively
AUROC
0.89
(95%
CI:
0.80–0.99).
Conclusions
Certain
species,
particularly
combination
,
butyriciproducens,
may
MAFLD
DM.
Language: Английский
Diet, microbiome, and probiotics establish a crucial link in vaccine efficacy
Critical Reviews in Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 26
Published: March 20, 2025
Vaccination
plays
a
critical
role
in
public
health
by
reducing
the
incidence
and
prevalence
of
infectious
diseases.
The
efficacy
vaccine
has
numerous
determinants,
which
include
age,
sex,
genetics,
environment,
geographic
location,
nutritional
status,
maternal
antibodies,
prior
exposure
to
pathogens.
However,
little
is
known
about
gut
microbiome
how
it
can
be
targeted
through
dietary
interventions
improve
immunological
responses.
Unveiling
this
link
imperative,
particularly
post-pandemic
world,
considering
impaired
COVID-19
response
observed
dysbiotic
individuals.
Therefore,
article
aims
comprehensively
review
diet
probiotics
modulate
composition,
linked
efficacy.
Dietary
fiber
polyphenolic
compounds
derived
from
plant-based
foods
microbial
diversity
promoting
growth
short-chain
fatty
acids-producing
microbes.
On
other
hand,
animal-based
have
mixed
effects
–
whey
protein
fish
oil
promote
eubiosis
In
contrast,
lard
red
meat
adverse
effects.
Studies
further
indicate
that
probiotic
supplements
exert
varied
effects,
mostly
strain
dosage-specific.
Interlinking
diet,
microbiome,
probiotics,
vaccines
will
reveal
opportunities
for
newer
research
on
diet-induced
microbiome-manipulated
precision
vaccination
strategies
against
Language: Английский
Systematic review of the impact of intestinal microbiota on vaccine responses
npj Vaccines,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Dec. 20, 2024
Abstract
The
intestinal
microbiota
plays
a
critical
role
in
host
immunity
and
might
contribute
to
the
significant
variation
between
individuals’
vaccine
responses.
A
systematic
search
was
done
using
MEDLINE
Embase
identify
original
human
studies
investigating
association
composition
humoral
cellular
In
total,
30
publications
(26
studies,
14
infants,
12
adults),
were
included.
Of
these,
26
found
an
beneficial
effect
of
Actynomycetota
(particularly
Bifidobacterium
)
detrimental
Pseudomonadota
Gammaproteobacteria)
observed
across
studies.
Study
designs
highly
heterogenous,
with
type,
outcome
measure,
timing
stool
analysis
methods.
Overall,
support
concept
that
influences
Further
adequately
powered
are
needed
confirm
this
inform
potential
microbiota-targeted
interventions
optimise
Language: Английский