The Dynamics of Antibody Titres Against SARS-CoV-2 in Vaccinated Healthcare Workers: A Systemic Literature Review DOI Creative Commons

Vilija Gurkšnienė,

Tadas Alčauskas,

Fausta Majauskaitė

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1419 - 1419

Published: Dec. 16, 2024

Background and Objectives: Given that COVID-19 vaccination is a relatively recent development, particularly when compared to immunisation against other diseases, it crucial assess its efficacy in vaccinated populations. This literature review analysed studies monitored antibody titres SARS-CoV-2 healthcare workers who received vaccines. Methods: Using the PICO (Population, Intervention, Comparators, Outcomes) model recommended PRISMA (Preferred Reporting Items for Systematic Reviews Meta-Analyses) guidelines we included 43 publications which analyse dynamics following primary vaccination, effects of booster doses, influence factors such as COVID-19C infection, age, sex on kinetics. Results: All demonstrated strong immunogenic response Re-gardless vaccine used, over 95% pre-vaccination seronegative population be-came seropositive all studies. Depending sampling intervals provided by re-searchers, levels were quantitatively highest during first three months after but inevitably declined time. The monthly decline antibodies observed these highlighted necessity doses. Studies analysing impact revaccination have confirmed an effective tool boost humoral immunity SARS-CoV-2. An-tibodies appear persist longer period time revaccination, although they are subject similar influencing dynamics, comorbidities, exposure COVID-19. In addition, heterogeneous strategies been shown be more than homogeneous revaccination. Conclusions: Our leaving question ongoing open. reviewed evidence effectiveness despite differences sex, prior infection. suggests repeated remains highly method mitigating continued threat posed

Language: Английский

Canadian health care providers' and education workers' hesitance to receive original and bivalent COVID-19 vaccines DOI Creative Commons
Brenda L. Coleman, Iris Gutmanis, Susan J. Bondy

et al.

Vaccine, Journal Year: 2024, Volume and Issue: 42(24), P. 126271 - 126271

Published: Sept. 2, 2024

Background: The demand for COVID-19 vaccines has diminished as the pandemic lingers. Understanding vaccine hesitancy among essential workers is important in reducing impact of future pandemics by providing effective immunization programs delivered expeditiously. Method: Two surveys exploring acceptance 2021 and 2022 were conducted cohorts health care providers (HCP) education participating prospective studies illnesses uptake. Demographic factors opinions about (monovalent bivalent) public measures collected these self-reported surveys. Modified multivariable Poisson regression was used to determine associated with hesitancy. Results: In 2021, 3 % 2061 HCP 6 3417 reported (p < 0.001). December 2022, 21 868 24 1457 being hesitant receive a bivalent = 0.09). Hesitance be vaccinated monovalent earlier date survey completion, later receipt first dose, no influenza vaccination, less worry becoming ill COVID-19. Factors hesitance that common both two or fewer previous doses lower certainty safe effective. Conclusion: Education somewhat more likely than report but reasons similar. Hesitancy non-receipt (i.e., behaviour), concern infected SARS-CoV-2, concerns safety effectiveness cohorts. Maintaining inter-pandemic trust vaccines, ensuring rapid data generation during regarding effectiveness, transparent communication are all needed support vaccination programs.

Language: Английский

Citations

3
The Dynamics of Antibody Titres Against SARS-CoV-2 in Vaccinated Healthcare Workers: A Systemic Literature Review DOI Creative Commons

Vilija Gurkšnienė,

Tadas Alčauskas,

Fausta Majauskaitė

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1419 - 1419

Published: Dec. 16, 2024

Background and Objectives: Given that COVID-19 vaccination is a relatively recent development, particularly when compared to immunisation against other diseases, it crucial assess its efficacy in vaccinated populations. This literature review analysed studies monitored antibody titres SARS-CoV-2 healthcare workers who received vaccines. Methods: Using the PICO (Population, Intervention, Comparators, Outcomes) model recommended PRISMA (Preferred Reporting Items for Systematic Reviews Meta-Analyses) guidelines we included 43 publications which analyse dynamics following primary vaccination, effects of booster doses, influence factors such as COVID-19C infection, age, sex on kinetics. Results: All demonstrated strong immunogenic response Re-gardless vaccine used, over 95% pre-vaccination seronegative population be-came seropositive all studies. Depending sampling intervals provided by re-searchers, levels were quantitatively highest during first three months after but inevitably declined time. The monthly decline antibodies observed these highlighted necessity doses. Studies analysing impact revaccination have confirmed an effective tool boost humoral immunity SARS-CoV-2. An-tibodies appear persist longer period time revaccination, although they are subject similar influencing dynamics, comorbidities, exposure COVID-19. In addition, heterogeneous strategies been shown be more than homogeneous revaccination. Conclusions: Our leaving question ongoing open. reviewed evidence effectiveness despite differences sex, prior infection. suggests repeated remains highly method mitigating continued threat posed

Language: Английский

Citations

0