Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications DOI Creative Commons
Kam W. Leong,

Seng Kong Tham,

Chit Laa Poh

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 12, 2025

Messenger RNA (mRNA) vaccines have emerged as a transformative platform in modern vaccinology. mRNA vaccine is powerful alternative to traditional due their high potency, safety, and efficacy, coupled with the ability for rapid clinical development, scalability cost-effectiveness manufacturing. Initially conceptualized 1970s, first study about effectiveness of against influenza was conducted 1993. Since then, development has rapidly gained significance, especially combating COVID-19 pandemic. Their unprecedented success during pandemic, demonstrated by Pfizer-BioNTech Moderna vaccines, highlighted potential. This review provides comprehensive analysis technology, detailing structure its mechanism action inducing immunity. Advancements nanotechnology, particularly lipid nanoparticles (LNPs) delivery vehicles, revolutionized field. The manufacturing processes, including upstream production, downstream purification, formulation are also reviewed. progress targeting viruses causing infectious diseases discussed, emphasizing versatility therapeutic Despite success, faces several challenges, improved stability reduce dependence on cold chain logistics transport, enhanced mechanisms target specific tissues or cells, addressing risk rare adverse events. High costs associated encapsulation LNPs potential unequal global access further complicate widespread adoption. As world continues confront emerging viral threats, overcoming these challenges will be essential fully harness vaccines. It anticipated that play major role defining shaping future health.

Language: Английский

mRNA vaccine platforms: linking infectious disease prevention and cancer immunotherapy DOI Creative Commons
Dariush Haghmorad, Majid Eslami,

Niloufar Orooji

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 12, 2025

The advent of mRNA vaccines, accelerated by the global response to COVID-19 pandemic, marks a transformative shift in vaccine technology. In this article, we discuss development, current applications, and prospects vaccines for both prevention treatment infectious diseases oncology. By leveraging capacity encode antigens within host cells directly, provide versatile scalable platform suitable addressing broad spectrum pathogens tumor-specific antigens. We highlight recent advancements design, innovative delivery mechanisms, ongoing clinical trials, with particular emphasis on their efficacy combating diseases, such as COVID-19, Zika, influenza, well emerging potential cancer immunotherapy. also address critical challenges, including stability, optimization immune responses, broader issue accessibility. Finally, review strategies advancing next-generation aim overcoming limitations technology enhancing preventive therapeutic approaches oncological diseases.

Language: Английский

Citations

1
Revolutionizing immunization: a comprehensive review of mRNA vaccine technology and applications DOI Creative Commons
Kam W. Leong,

Seng Kong Tham,

Chit Laa Poh

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 12, 2025

Messenger RNA (mRNA) vaccines have emerged as a transformative platform in modern vaccinology. mRNA vaccine is powerful alternative to traditional due their high potency, safety, and efficacy, coupled with the ability for rapid clinical development, scalability cost-effectiveness manufacturing. Initially conceptualized 1970s, first study about effectiveness of against influenza was conducted 1993. Since then, development has rapidly gained significance, especially combating COVID-19 pandemic. Their unprecedented success during pandemic, demonstrated by Pfizer-BioNTech Moderna vaccines, highlighted potential. This review provides comprehensive analysis technology, detailing structure its mechanism action inducing immunity. Advancements nanotechnology, particularly lipid nanoparticles (LNPs) delivery vehicles, revolutionized field. The manufacturing processes, including upstream production, downstream purification, formulation are also reviewed. progress targeting viruses causing infectious diseases discussed, emphasizing versatility therapeutic Despite success, faces several challenges, improved stability reduce dependence on cold chain logistics transport, enhanced mechanisms target specific tissues or cells, addressing risk rare adverse events. High costs associated encapsulation LNPs potential unequal global access further complicate widespread adoption. As world continues confront emerging viral threats, overcoming these challenges will be essential fully harness vaccines. It anticipated that play major role defining shaping future health.

Language: Английский

Citations

0