The Involvement and Manifestations of SARS-CoV-2 Virus in Cardiovascular Pathology

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 773 - 773

Published: April 22, 2025

Although the acute phase of COVID-19 pandemic has subsided, emergence post-COVID-19 condition presents a new and complex public health challenge, characterized by persistent, multisystem symptoms that can endure for weeks or months after initial infection with SARS-CoV-2 virus, significantly affecting survivors’ quality life. Among most concerning sequelae are cardiovascular complications, which encompass broad spectrum conditions, including arrhythmias, myocardial damage, postural orthostatic tachycardia syndrome. This narrative review explores burden on reviewing latest relevant findings in literature highlighting different aspects COVID-19’s involvement. investigates pathophysiological mechanisms underlying involvement condition, focus direct viral invasion via ACE2 receptors, immune-mediated injury, cytokine storm, systemic inflammation, endothelial dysfunction, mitochondrial injury. The interplay between pre-existing diseases, such as hypertension, atherosclerosis, diabetes, atrial fibrillation, is also explored, revealing individuals conditions at heightened risk both severe illness long-term complications. Long-term immune activation persistence antigens increasingly recognized contributors to ongoing even mild asymptomatic infections. As healthcare system continues adapt consequences pandemic, deeper understanding these manifestations essential. knowledge will inform development targeted strategies prevention, clinical management, rehabilitation affected patients. Furthermore, insights gained from intersection be instrumental shaping responses future epidemics, necessity multidisciplinary approaches patient care preparedness.

Language: Английский

SARS-CoV-2 spike protein: structure, viral entry and variants

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

The Role of Cardiac Magnetic Resonance in mRNA COVID-19 Vaccine-Related Myopericarditis: An Evolutive Case Series

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(9), P. 259 - 259

Published: Aug. 25, 2024

Numerous cases of myocarditis related to mRNA vaccines for COVID-19 have recently been described, usually in young men. Long-term evolutive cardiac magnetic resonance imaging (CMR) data are lacking. We describe four consecutive vaccine-induced myocarditis. The pathological findings confirmed the diagnosis acute phase, showing edema, as well pericardial enhancement, with light effusion and late gadolinium enhancement (LGE), predominantly inferolateral wall. These highlight unique value patients suspected induced by RNAm a tool confirm diagnosis, avoiding other invasive techniques, long-term follow-up patients. Our iterative CMR demonstrated frequent LGE persistence.

Language: Английский