Exosomes in Breast Milk: Their Impact on the Intestinal Microbiota of the Newborn and Therapeutic Perspectives for High-Risk Neonates DOI Open Access
Delia Cristóbal Cañadas,

Rocio Parrón-Carrillo,

Tesifón Parrón-Carreño

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3421 - 3421

Published: April 5, 2025

Breast milk exosomes are essential for the nutrition and immune development of newborn. These 30-150 nm extracellular vesicles contain microRNAs (miRNAs), mesessenger RNAS (mRNA)s, proteins lipids that facilitate cellular communication modulate neonatal system. In this article, we analyse impact breast on intestinal microbiota newborn, especially in high-risk neonates such as preterm infants or at risk necrotising enterocolitis (NEC). Exosomes promote colonisation beneficial bacteria Bifidobacterium Lactobacillus strengthen barrier. They also regulate response, balancing defence against pathogens tolerance to non-pathogenic antigens. This effect is key infants, who benefit from their anti-inflammatory preventive properties complications NEC. Research points potential therapeutic uses care, opening up new opportunities improve health vulnerable newborns through protective effects exosomes.

Language: Английский

Exosomes in Breast Milk: Their Impact on the Intestinal Microbiota of the Newborn and Therapeutic Perspectives for High-Risk Neonates DOI Open Access
Delia Cristóbal Cañadas,

Rocio Parrón-Carrillo,

Tesifón Parrón-Carreño

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3421 - 3421

Published: April 5, 2025

Breast milk exosomes are essential for the nutrition and immune development of newborn. These 30-150 nm extracellular vesicles contain microRNAs (miRNAs), mesessenger RNAS (mRNA)s, proteins lipids that facilitate cellular communication modulate neonatal system. In this article, we analyse impact breast on intestinal microbiota newborn, especially in high-risk neonates such as preterm infants or at risk necrotising enterocolitis (NEC). Exosomes promote colonisation beneficial bacteria Bifidobacterium Lactobacillus strengthen barrier. They also regulate response, balancing defence against pathogens tolerance to non-pathogenic antigens. This effect is key infants, who benefit from their anti-inflammatory preventive properties complications NEC. Research points potential therapeutic uses care, opening up new opportunities improve health vulnerable newborns through protective effects exosomes.

Language: Английский

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