Applied Biological Chemistry, Journal Year: 2025, Volume and Issue: 68(1)
Published: April 26, 2025
Language: Английский
Cancer Immunology Immunotherapy, Journal Year: 2024, Volume and Issue: 73(7)
Published: May 14, 2024
Abstract The majority of the immune cell population in tumor microenvironment (TME) consists tumor-associated macrophages (TAM), which are main players coordinating inflammation. TAM has a high plasticity and is divided into two phenotypes, pro-inflammatory M1 type anti-inflammatory M2 type, with tumor-suppressive tumor-promoting functions, respectively. Considering beneficial effects for anti-tumor macrophages, conversion to feasible positive treatment. This study sought evaluate whether glycopeptide derived from simulated digested Codonopsis pilosula extracts could regulate polarization M2-like toward phenotype potential regulatory mechanisms. results showed that after dCP1 treatment, mRNA relative expression levels some marker genes TME were reduced, inflammatory factor increased. Analysis RNA-Seq intervention gene sets such as glycolysis, associated macrophage phenotype, significantly up-regulated, whereas those IL-6-JAK-STAT3 pathway, down-regulated. Moreover, PCA analysis Pearson's correlation also indicated polarized at transcriptional level treatment dCP1. Lipid metabolomics was used further explore efficacy regulating phenotype. It found lipid metabolite profiles dCP1-treated metabolism compared blank TAM. key differential metabolites revealed interconversion between phosphatidylcholine (PC) diacylglycerol (DG) may be central reaction above suggest TME.
Language: Английский
Citations
4
Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Bioactive compounds from natural sources play an important role as immunomodulator in diseases such cancer, inflammatory and viral diseases. Immunomodulator functions to regulate the immune system defends against infectious foreign particles. Naturally occurring bioactive have been shown boost immunity increase anti-cancer response, well cancer patients. Prodigiosin is reported anticancer agent effective multiple tumor cell lines also combat Innate cytotoxicity one of main problems linked with use immunosuppressants, especially oncology that leads scientists toward application combined regimens. In this perception, prodigiosin offers interesting perspective combinatorial applications. However, major devastating limitation associated its strain: Serratia marcescens source a few harmful pathologies mammals. The present article will review potential roles key player different cells T B lymphocytes, macrophages, dendritic killer antiviral activity.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: 4(1)
Published: Jan. 1, 2025
Muscular dystrophies (MDs) are an array of inherited disorders characterized by progressive muscle weakness and degeneration. This review explores the genetic foundation, pathophysiological mechanisms, current treatments, therapeutic potential medicinal plants for MDs. Although gene therapy, exon-skipping, stem cell therapies substantial advancements, they encounter obstacles regarding immune responses, long-term efficacy, delivery efficiency. A promising complementary approach to conventional MD is presented natural compounds from plants. Recent studies historical use underscore multi-targeted effects phytochemicals, such as resveratrol, withaferin A, ginsenosides, curcumin, epigallocatechin gallate, on regeneration, oxidative stress, inflammation. These have demonstrated in pre-clinical enhance function, reduce inflammation, stress. Despite their potential, utilization treatment impeded regulatory hurdles, side effects, variability bioactive compound concentration, standardization issues. To address these challenges, it necessary implement rigorous clinical trials, protocols, comprehensive quality control measures. Future research should focus elucidating molecular mechanisms plant-derived compounds, improving biotechnological production techniques, integrating treatments into personalized, plans. Advances synthetic biology, genomics, metabolomics, nanoformulations improve efficacy safety phytomedicine MD. Implementing evidence-based integrative approaches can holistic care, patient outcomes, facilitate acceptance plant-based practice.
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 393 - 393
Published: Jan. 18, 2025
The interpretation of the biochemistry immune metabolism could be considered an attractive scientific field biomedicine research. In this review, role glycolysis in macrophage polarization is discussed together with mitochondrial cancer cells. first part, focus on Warburg effect and redox during polarization, development, management response by second part addresses possibility impacts through targeting peroxisome proliferator-activated receptors (PPARs). This activator native responses. Because reported serious adverse effects using synthetic ligands for PPARs combination chemotherapeutics, searches less toxic more active PPAR inhibitors, as well blocking undesirable cellular PPAR-dependent processes, are progress. On other hand, recent research modern immunotherapy has focused search gentle immune-modulating natural compounds harmless synergistic chemotherapeutic efficacy that can used adjuvant. It a well-known fact plant kingdom source important therapeutic agents multifaceted effectiveness. One these known association activities. regard, secondary metabolites extracted from plants change game.
Language: Английский
Citations
0
Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(2)
Published: Feb. 1, 2025
This systematic review delves into the potential of herbal remedies as anti-urticaria agents, examining recent advancements, current clinical status, and prospects. Despite advancements in conventional treatments, managing urticaria remains challenging. There is a growing interest drugs. A comprehensive literature search assessed studies on safety efficacy various herbs treatment. synthesizes key findings from trials, observational studies, experimental research, focusing evaluating used Indian Ayurveda Traditional Chinese Medicine. The discusses treatment mechanisms, synergies with therapies, challenges like chronic unpredictable nature, Identifying triggers, Variable response to treatment, side effects long-term quality life impact etc, standardization regulation. It emphasizes importance ongoing research therapies for urticaria, offering insights their role adjunctive or alternative treatments.
Language: Английский
Citations
0
Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42692 - e42692
Published: Feb. 1, 2025
This study investigates the immunomodulatory effects of various aqueous plant extracts on immune cells and cytokine production. In vitro, several extracts, including holy basil (Ocimum sanctum), patawali (Tinospora crispa), Indian borage (Plectranthus amboinicus L.), significantly increased CD3+ T-cell populations, while soap pod (Acacia concinna), garlic (Allium sativum neem (Azadirachta indica) also boosted CD45RA+ B-cells. vivo, had subtle spleen morphology Peyer's Patches, with milk bush (Euphorbia tirucalli L.) enhancing responses, stimulated Additionally, we observed that Neem suppressed B-cell populations. Furthermore, analysis showed reduced IL-2, pod, basil, TNF-alpha levels. Soap elevated IL-10 IL-17A, indicating both anti-inflammatory pro-inflammatory signaling, induced an increase in IL-4. conclusion, Thai medicinal plants show strong potential as immunostimulants immunosuppressants. They can enhance lymphocyte proliferation, particularly T-cells, modulate Their play a key role regulating Th1, Th2, Th17 Thus, these could serve natural agents alternative medicines for boosting or modulating function.
Language: Английский
Citations
0
Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(3)
Published: Feb. 17, 2025
Language: Английский
Citations
0
International Dairy Journal, Journal Year: 2025, Volume and Issue: unknown, P. 106222 - 106222
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12
Published: March 7, 2025
Heat stress significantly impacts dairy cow productivity, health, and welfare. This study evaluated a self-developed herbal formula as dietary intervention to mitigate heat stress. A total of 198 lactating cows were divided into two groups: Control group receiving standard mixed rations Herbs supplemented with for 60 days. Various parameters assessed, including milk yield composition, antioxidant capacity, immune responses, stress-related gene expression, rumen microbial composition. Compared the group, in showed improved feed intake, quality, rumination frequency, enhanced activity response. Rumen microbiome analysis revealed reduced relative abundance Proteobacteria Ochrobactrum along an enrichment beneficial genera such Lachnospira . Functional predictions indicated that exhibited glycolysis/gluconeogenesis, pyruvate metabolism, starch sucrose reflecting fermentation efficiency energy utilization. In conclusion, physiological biochemical attributes, boosted modulated microbiome, contributing alleviation cows. These findings highlight its potential natural strategy support health productivity under conditions.
Language: Английский
Citations
0
Plants, Journal Year: 2025, Volume and Issue: 14(6), P. 897 - 897
Published: March 13, 2025
The rising prevalence of infectious diseases and immune-related disorders underscores the need for effective accessible therapeutic solutions. Herbal immunostimulants derived from medicinal plants offer promising alternatives, enhancing immune responses with lower toxicity fewer side effects than synthetic drugs. This review explores immunostimulatory potential Morinda citrifolia, Echinacea purpurea, Phyllanthus niruri, focusing on their bioactive compounds, mechanisms action, relevance. These modulate innate adaptive by activating macrophages, dendritic cells, lymphocytes while regulating cytokine production to maintain homeostasis. Their immunomodulatory are linked key signaling pathways, including NF-κB, MAPK, JAK/STAT. In vitro in vivo studies highlight strengthen control inflammation, making them candidates managing diseases. However, further research is needed standardize formulations, determine optimal dosages, validate safety efficacy clinical settings. Addressing these gaps will support integration herbal into evidence-based healthcare as sustainable immune-enhancing strategies.
Language: Английский
Citations
0