Toxicon, Journal Year: 2024, Volume and Issue: 240, P. 107640 - 107640
Published: Feb. 5, 2024
Language: Английский
European Polymer Journal, Journal Year: 2024, Volume and Issue: 215, P. 113243 - 113243
Published: July 1, 2024
Osteoarthritis (OA) is a well-known degenerative joint disease recognized by the deterioration of cartilage in joints, leading to pain and reduced mobility. Traditional treatments for OA include management, physical therapy, severe cases, replacement surgery. In recent years, there has been growing interest exploring potential phytoconstituents nanomedicines combined treating OA. Furthermore, with increasing amount study this field, now opportune time widespread use plant-derived medications as complementary alternative medical therapies be acknowledged used more efficient treatment human ailments like Combining nanomedicine technology (phyto-nanomedicine) can potentially enhance their effectiveness The phyto-nanomedicines many advantages, including enhanced permeability, increased bioavailability, sustained/controlled drug release at site, decreased adverse effects, possible combination treatment. It's important note that while promising preclinical some clinical evidence regarding phyto-nanomedicine treatment, further research needed establish safety efficacy conclusively. review, treat combining phytomedicines nanoparticulate delivery former therapeutic discussed detail. we have also described briefly on application organ-on-chip and/or on-chip models accelerate identification novel evaluate potency
Language: Английский
Citations
7
Animals, Journal Year: 2024, Volume and Issue: 14(8), P. 1159 - 1159
Published: April 11, 2024
The aim of this study was to evaluate the effect dried Cannabis sativa L. leaves as a phytogenic mixture added broiler feed on CD4+ and CD8+ T lymphocyte subpopulations, Newcastle disease virus (NDV) antibody titres, presence E. coli in faecal samples. conducted 100 male Ross 308 broilers, divided into four groups 25 for 42-day research period. were housed separately boxes litter softwood shavings fed starter from day 1 21 finisher 22 42. Industrial hemp (C. sativa) grown Crkvina area, Croatia (latitude: 45°18′46.8″ N; longitude: 15°31′30″ E). manually separated, sun-dried, ground powder. offered control group did not contain cannabis leaves, whereas three experimental received mixtures containing mixed quantity 10 g/kg, 20 or 30 g/kg (E_10, E_20, E_30, respectively). mean NDV level uniform all until post-vaccination 14 increased comparably with time. percentage lymphocytes peripheral blood subpopulation showed statistically significant differences (p < 0.001) E_20 compared both E_10 E_30 throughout As age increased, CD4+-to-CD8+ ratios also 0.0001) 42 group. Comparing indicated that bacterial count lower having addition C. leaves. In conclusion, found elicit favourable immunomodulatory cell-mediated humoral immune responses broilers via subpopulations higher CD4+:CD8+ cell ratios, thus indicating enhanced function capacity. addition, may have complementary effects response, increase broilers’ resistance infectious diseases, reduce stress associated vaccination, improve health welfare.
Language: Английский
Citations
5
Life, Journal Year: 2024, Volume and Issue: 14(8), P. 1037 - 1037
Published: Aug. 20, 2024
The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties thymol, carvacrol, their equimolar mixture. Antioxidant activities were assessed using DPPH, ABTS, ORAC methods. thymol/carvacrol mixture exhibited significant synergism, surpassing individual compounds ascorbic acid in DPPH (IC
Language: Английский
Citations
5
Agriculture, Journal Year: 2023, Volume and Issue: 13(3), P. 698 - 698
Published: March 17, 2023
The implication of heat stress (HS) in the oxidative phenomenon and its related diseases chickens has been widely reported. Salicin is a precursor for synthesis salicylic acid aspirin obtained from bark Salix alba, with an undeniable anti-inflammatory effect. However, little attention paid to salicin’s antioxidant/oxidative stress-reducing effect compared well-known purpose study was investigate dietary salicin standardized extract alba (SAB) on biomarkers intestinal microflora broiler exposed stress. In our study, (14 days) were randomly allocated three treatment groups (SAB0; SAB25; SAB50), each which included five replicates eight birds per replicate. Broilers (32 ± 2 °C) between 14 42 days. liver tissues collected analyze (total antioxidant capacity, glutathione, catalase, superoxide dismutase). content measurements microbial population performed (E. coli, staphylococci, lactobacilli). Results indicated that malondialdehyde protein carbonyls activity decreased (p < 0.05) SAB50 concomitantly linearly increased total glutathione concentration. Dietary supplementation SAB reduced abundance staphylococci number lactobacilli. Taken together, possesses advantageous status balance broilers These findings provide new insight into potential use damage prevention dysbiosis
Language: Английский
Citations
11
Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 141 - 154
Published: Jan. 1, 2025
The overuse of antimicrobials in food-producing animals, particularly poultry, has led to growing concerns about multidrug microbial resistance, posing significant risks both animal and human health. Subtherapeutic doses antibiotics have traditionally been used enhance growth improve economic efficiency poultry farming. However, these practices facilitated the emergence resistant strains, threatening global health security prompting a search for sustainable alternatives. This review highlights significance phytogenic as feed additives (PFAs) promising substitutes antibiotic (AFAs) production. PFAs, derived from plant-based compounds, exhibit multiple beneficial properties, including antimicrobial, antioxidative, anti-inflammatory, immune-modulatory effects. Moreover, they offer potential produce high-quality organic products while reducing likelihood resistance. Despite advantages, inconsistent results among studies underscore importance standardized approaches maximize their efficacy. aims evaluate current status use farming globally, explore properties mechanisms assess viable alternatives antibiotics. By consolidating available knowledge, this provides insights into benefits challenges associated with offering guidance future research practical applications
Language: Английский
Citations
0
Animal Biotechnology, Journal Year: 2025, Volume and Issue: 36(1)
Published: Feb. 13, 2025
The study assessed the inclusion level effects of a phytogenic blend (PB) on performance and critical molecular biomarkers related to detoxification (Aryl hydrocarbon receptor; AhR) antioxidant (Nuclear factor-erythroid 2-related factor 2; Nrf2) responses in layers' ovary liver. Layers (n = 385; 21-week-old; Hy-Line Brown) were allotted 5 treatments with 7 replicates 11 hens each, for 12-week feeding trial. Treatments were: control (CON) without PB or supplementation at 250 (PB250), 750 (PB750), 1000 (PB1000) 1500 mg/kg diet (PB1500), respectively. Performance was determined weekly experimental period. At 6th 12th week ovarian liver samples collected gene expression analysis. Increasing level, improved linearly quadratically overall laying rate, egg mass FCR, optimal (P ≤ 0.001) notable PB750 compared CON. nutrigenomic analysis revealed that resulted 0.05) consistent beneficial modulation AhR/Nrf2 pathway-related genes week, both hens. In conclusion, beneficially modulated hepatic adaptive cytoprotection supported improvements recorded, displaying benefits.
Language: Английский
Citations
0
Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 598 - 598
Published: Feb. 19, 2025
This study investigated the effects of a phytochemical-Lactobacilli blend (PEL) on performance and health late-pregnant does. Thirty Zaraibi does (30.9 ± 0.37 kg body weight, 3-3.5 years old, 90 days pregnant) were randomly assigned to three experimental groups, ensuring equal distribution based parity, litter size, previous lactation milk production. The fed either control diet (no supplementation) or PEL-supplemented (control plus 2 g 4 PEL per day) for 60 days. supplementation linearly improved (p < 0.05) feed intake, nutrient digestibility, ruminal concentrations acetic propionic acids, while significantly reducing ammonia-N concentrations. reduced feeding rumination times increasing idling time. Blood hematological parameters with supplementation. Serum protein, liver kidney function indicators, lipid metabolism, cortisol, thyroid hormone levels 0.01) in linear manner Antioxidant status, pro-inflammatory cytokines, immune response enhanced both quadratically treatment. Gene expression analysis revealed upregulation growth, immune, antioxidant-related genes These findings suggest that supplementing pregnant day can effectively enhance their performance, health, metabolic status.
Language: Английский
Citations
0
World s Poultry Science Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36
Published: Feb. 28, 2025
Language: Английский
Citations
0
Animals, Journal Year: 2025, Volume and Issue: 15(6), P. 808 - 808
Published: March 12, 2025
This research aimed to evaluate the effects of an olive pomace extract (OE) and a fat-encapsulated composed blend oleoresins from Capsicum sp., black pepper, ginger (SPICY) on broiler chicken performance antioxidant function. In total, 640 1-day-old male chicks were randomly assigned five experimental diets (eight replicates/treatment, 16 birds/replicate). Diets included basal diet with no added vitamin E (NC), NC plus 100 ppm (PC), 1250 OE, 250 (SPICY), OE SPICY (SPIOE). Phytogenic additives supplied by Lucta S.A., Spain. Compared NC, PC significantly (p < 0.05) increased ADG 8 14 days age, both showing intermediate values between controls. At end this trial, at 35 significant increase in plasma GPx activity was observed PC-fed birds compared malonyl dialdehyde (MDA) total capacity. Birds fed displayed The expression heat shock protein 70 (HSP70) glutathione S-Transferase Alpha 4 (GSTA4) lower jejunal mucosa NC. Moreover, HSP70 but not different extracts conclusion, useful maintaining growth vit E-supplemented diets, particularly case mediated its action through HSP70.
Language: Английский
Citations
0
Poultry Science, Journal Year: 2025, Volume and Issue: 104(5), P. 105071 - 105071
Published: March 20, 2025
Heat stress is a critical challenge in the poultry industry. It arises when birds are exposed to elevated ambient temperatures beyond their thermoneutral zone, often exacerbated by high humidity and inadequate ventilation. This condition disrupts birds' ability maintain thermal homeostasis, leading physiological behavioral changes such as increased panting, reduced feed intake, water consumption. These responses aim dissipate heat but result energy imbalances, oxidative stress, impaired immune function. Green tea polyphenols (GTPs) mitigate modulating pathways, primarily scavenging reactive oxygen species (ROS) enhancing antioxidant defense mechanisms. pathways play pivotal role neutralizing ROS generated during inflammation, exposure electrophilic compounds. action helps restore cellular balance enhances overall mechanisms converting harmful free radicals into less molecules, oxygen. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays significant character activation of enzymatic antioxidants network. translocates nucleus upon activation, binds response elements (AREs) promoter regions target genes, upregulates expression key enzymes. Therefore, regulation Nrf2 considered molecular marker mitigating effects its detoxification enzymes, protecting against damage inflammation induced temperatures. exploratory review summarizes anti-oxidative GTPs poultry. highlights cytoprotective basis epigallocatechin-3-gallate (EGCG), particularly Nrf2-mediated which enhance systems protect damage.
Language: Английский
Citations
0