Metagenomic Analysis of Tick-Borne Viruses in Hulunbuir, Inner Mongolia, China: Epidemiological Risk of Potential Novel Pathogenic Viruses Relevant to Public Health DOI Creative Commons
Zhang You,

Xiuying Tian,

Ruoyan Peng

et al.

Zoonoses, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 1, 2025

Objective: Inner Mongolia, with its vast grasslands providing ideal habitats for ticks, has recently emerged as a hotspot of novel tick-borne virus (TBV) prevalence. However, the diversity TBVs and their potential spillover risks remain to be elucidated. Methods: In 2021, we collected 500 Haemaphysalis longicornis , Ixodes persulcatus Dermacentor silvarum ticks from Hulunbuir, conducted virome analysis viral surveillance evaluate TBV exposure risk in Hulunbuir. Results: A total 26 species belonging nine families were identified, including four viruses (Yiliekede tick 1 [YLTV1, Rhabdoviridae ], Meitian [MtTV, Phenuiviridae Wunuer pestivirus, phlebovirus) 11 new strains human-pathogenic (including Songling [SGLV], Beiji nairovirus [BJNV], Nuomin [NOMV]), three dominant species. Virome profiling revealed striking species-specific patterns: I. exhibited highest richness abundance, dominated by Chuviridae (NOMV) ; D. uniquely carried (MtTV); H. showed Nairoviridae predominance (SGLV, BJNV). Phylogenetic analyses demonstrated that MtTV clustered Tacheng 2, NOMV-YL high similarity clinical NOMV isolates febrile patients. Regional MtTV’s pan-regional circulation across locations (MIR=4–8%), contrasting localized Yiliekede foci SGLV (MIR=0.6%), BJNV (0.4%), (1.0%). Conclusions: This study not only mapped landscape key pastoral region, but also highlighted TBVs, MtTV, YLTV1, SGLV, BJNV, NOMV. Our findings underscore urgent need One Health strategies monitoring emerging at tick-human-livestock interface northern China.

Language: Английский

Metagenomic Analysis of Tick-Borne Viruses in Hulunbuir, Inner Mongolia, China: Epidemiological Risk of Potential Novel Pathogenic Viruses Relevant to Public Health DOI Creative Commons
Zhang You,

Xiuying Tian,

Ruoyan Peng

et al.

Zoonoses, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 1, 2025

Objective: Inner Mongolia, with its vast grasslands providing ideal habitats for ticks, has recently emerged as a hotspot of novel tick-borne virus (TBV) prevalence. However, the diversity TBVs and their potential spillover risks remain to be elucidated. Methods: In 2021, we collected 500 Haemaphysalis longicornis , Ixodes persulcatus Dermacentor silvarum ticks from Hulunbuir, conducted virome analysis viral surveillance evaluate TBV exposure risk in Hulunbuir. Results: A total 26 species belonging nine families were identified, including four viruses (Yiliekede tick 1 [YLTV1, Rhabdoviridae ], Meitian [MtTV, Phenuiviridae Wunuer pestivirus, phlebovirus) 11 new strains human-pathogenic (including Songling [SGLV], Beiji nairovirus [BJNV], Nuomin [NOMV]), three dominant species. Virome profiling revealed striking species-specific patterns: I. exhibited highest richness abundance, dominated by Chuviridae (NOMV) ; D. uniquely carried (MtTV); H. showed Nairoviridae predominance (SGLV, BJNV). Phylogenetic analyses demonstrated that MtTV clustered Tacheng 2, NOMV-YL high similarity clinical NOMV isolates febrile patients. Regional MtTV’s pan-regional circulation across locations (MIR=4–8%), contrasting localized Yiliekede foci SGLV (MIR=0.6%), BJNV (0.4%), (1.0%). Conclusions: This study not only mapped landscape key pastoral region, but also highlighted TBVs, MtTV, YLTV1, SGLV, BJNV, NOMV. Our findings underscore urgent need One Health strategies monitoring emerging at tick-human-livestock interface northern China.

Language: Английский

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